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Ptger3 - prostaglandin E receptor 3 Gene

Also Known as EP3; EP3R; Rep3; rEP3a; rEP3b

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24929

Summary

Enables prostaglandin E receptor activity. Involved in several processes, including negative regulation of G protein-coupled receptor signaling pathway; negative regulation of transport; and positive regulation of smooth muscle contraction. Located in several cellular components, including brush border membrane; nuclear membrane; and proximal neuron projection. Used to study asthma and withdrawal disorder. Biomarker of colon cancer; membranous glomerulonephritis; and renovascular hypertension. Orthologous to human PTGER3 (prostaglandin E receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Ptger3 Products (1)

mRNA	Protein	Name
NM_012704.1	NP_036836.1	prostaglandin E2 receptor EP3 subtype

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables prostaglandin E receptor activity	IDA IDA: Inferred from direct assay	10336471	RGD
enables prostaglandin E receptor activity	IMP IMP: Inferred from mutant phenotype	9350980	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cAMP biosynthetic process	IMP IMP: Inferred from mutant phenotype	11278900	RGD
involved in cAMP/PKA signal transduction	IMP IMP: Inferred from mutant phenotype	11278900	RGD
involved in cellular response to forskolin	IMP IMP: Inferred from mutant phenotype	15937517	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	16405508	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	14636300	RGD
involved in cellular response to prostaglandin E stimulus	IMP IMP: Inferred from mutant phenotype	11278900	RGD
involved in desensitization of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9350980	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	10819751	RGD
involved in intestine smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	24170253	RGD
involved in maternal process involved in parturition	IEP IEP: Inferred from expression pattern	19801535	RGD
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9013884	RGD
involved in negative regulation of calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	10670413	RGD
involved in negative regulation of circadian sleep/wake cycle, wakefulness	IMP IMP: Inferred from mutant phenotype	10923657	RGD
involved in negative regulation of forebrain neuron differentiation	IMP IMP: Inferred from mutant phenotype	19555672	RGD
involved in negative regulation of gastrin-induced gastric acid secretion	IMP IMP: Inferred from mutant phenotype	15961884	RGD
involved in negative regulation of insulin secretion	IDA IDA: Inferred from direct assay	10531320	RGD
involved in negative regulation of norepinephrine secretion	IMP IMP: Inferred from mutant phenotype	12524145	RGD
involved in negative regulation of potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	18496512	RGD
involved in positive regulation of calcitonin secretion	IMP IMP: Inferred from mutant phenotype	11278900	RGD
involved in positive regulation of circadian sleep/wake cycle, non-REM sleep	IMP IMP: Inferred from mutant phenotype	10923657	RGD
involved in positive regulation of colon smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	24170253	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	8743550	RGD
involved in positive regulation of gastric mucosal blood circulation	IMP IMP: Inferred from mutant phenotype	10807413	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17408863	RGD
involved in positive regulation of inhibitory G protein-coupled receptor phosphorylation	IMP IMP: Inferred from mutant phenotype	15937517	RGD
involved in positive regulation of myofibroblast contraction	IMP IMP: Inferred from mutant phenotype	19239477	RGD
involved in positive regulation of neutrophil extravasation	IMP IMP: Inferred from mutant phenotype	15944932	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	15937517	RGD
involved in positive regulation of smooth muscle contraction involved in micturition	IMP IMP: Inferred from mutant phenotype	18562635	RGD
involved in positive regulation of substance P secretion	IMP IMP: Inferred from mutant phenotype	11278900	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	10747002	RGD
involved in prostaglandin receptor internalization	IMP IMP: Inferred from mutant phenotype	15937517	RGD
involved in receptor internalization	IMP IMP: Inferred from mutant phenotype	15937517	RGD
involved in regulation of circadian sleep/wake cycle, wakefulness	IMP IMP: Inferred from mutant phenotype	10923657	RGD
involved in regulation of norepinephrine secretion	IMP IMP: Inferred from mutant phenotype	12524145	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	10819751	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	19801535	RGD
involved in response to salt	IEP IEP: Inferred from expression pattern	10432392	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19801535	RGD
involved in urinary bladder smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	18562635	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in brush border membrane	IDA IDA: Inferred from direct assay	15292051	RGD
located in cell surface	IDA IDA: Inferred from direct assay	15937517	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	20336467	RGD
located in nuclear membrane	IDA IDA: Inferred from direct assay	10336471	RGD
located in proximal neuron projection	IDA IDA: Inferred from direct assay	21104189	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
prostaglandin E2 receptor EP3 subtype	PGE receptor, EP3 subtype PGE2 receptor EP3 subtype prostaglandin E receptor 3 (subtype EP3) prostanoid EP3 receptor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11377	PTGER3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20586	Ptger3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27094	Ptger3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptger3	NCBI	NCBI:5733