PTGER3 - prostaglandin E receptor 3 Gene

Also Known as EP3; EP3e; EP3-I; EP3-II; EP3-IV; EP3-VI; PGE2-R; EP3-III; lnc003875

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5733

About PTGER3

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:70,852,358-71,047,816 (from NCBI)

This gene has 9 transcripts (splice variants), 197 orthologues and 7 paralogues. Biased expression in endometrium (RPKM 21.7), kidney (RPKM 19.2) and 8 other tissues.

Summary

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

PTGER3 Products (7)

mRNA Protein Name
NM_001126044.2 NP_001119516.1 prostaglandin E2 receptor EP3 subtype isoform 4
NM_198714.2 NP_942007.1 prostaglandin E2 receptor EP3 subtype isoform 4
NM_198715.3 NP_942008.1 prostaglandin E2 receptor EP3 subtype isoform 5
NM_198716.2 NP_942009.1 prostaglandin E2 receptor EP3 subtype isoform 6
NM_198717.2 NP_942010.1 prostaglandin E2 receptor EP3 subtype isoform 7
NM_198718.2 NP_942011.1 prostaglandin E2 receptor EP3 subtype isoform 8
NM_198719.2 NP_942012.1 prostaglandin E2 receptor EP3 subtype isoform 4

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in plasma membrane IDA
IDA: Inferred from direct assay
31097585 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGER3 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (65 - 346)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
Protein Preferred Names Protein Names

prostaglandin E2 receptor EP3 subtype

  • PGE receptor, EP3 subtype

Related Diseases

Diseases Alias
Mast Cell Neoplasm

  • Mastocytoma

  • Mast Cell Proliferative Disease

  • Mast Cell Tumor

  • Benign Mastocytoma
Primary Hypertrophic Osteoarthropathy

  • Pachydermoperiostosis Syndrome

  • Osteoarthropathy, Primary Hypertrophic

  • Pachydermoperiostosis Of Nail

  • Idiopathic Hypertrophic Osteoarthropathy

  • Pho
Ocular Hyperemia

  • Hyperemia Eye

  • Hyperemia Of Conjunctiva
Fallopian Tube Clear Cell Adenocarcinoma

  • Clear Cell Carcinoma Of The Fallopian Tube
Mucocele Of Appendix

  • Appendicele Mucocele

  • Appendicular Mucocele

  • Appendiceal Mucocele
Urethral Calculus

  • Calculus In Urethra

  • Urethral Stone

  • Urethrolithiasis

  • Urethra Calculi Impaction

  • Urethra Calculus Impaction

  • Urethra Stone

  • Calculous Urethritis

  • Urethral Calculi Impaction

  • Urethral Calculus Impaction
Severe Cutaneous Adverse Reaction

  • Stevens-Johnson Syndrome

  • Toxic Epidermal Necrolysis

  • Drug-Induced Stevens Johnson Syndrome

  • Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum

  • Susceptibility To Severe Cutaneous Adverse Reaction

  • Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

  • Lyell'S Syndrome

  • Lyell Syndrome

  • Severe Cutaneous Adverse Reaction, Susceptibility To

  • Hypersensitivity Syndrome, Carbamazepine-Induced, Susceptibility To

  • Hypersensitivity Syndrome, Carbamazepine-Induced

  • Stevens-Johnson Syndrome, Susceptibility To

  • Toxic Epidermal Necrolysis, Susceptibility To

  • Sjs/Ten

  • Susceptibility To Severe Cutaneous Adverse Reaction Ity To

  • Mycoplasma-Induced Stevens Johnson Syndrome

  • Dermatostomatitis, Stevens Johnson Type

  • Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum

  • Sjs-Ten

  • Toxic Epidermolysis

  • SJS

  • Dermatostomatitis Stevens Johnson Type

  • Ten

  • Sjs/Ten - [Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis]

  • Ten - [Toxic Epidermal Necrolysis]
Patent Ductus Arteriosus 1

  • Patent Ductus Arteriosus

  • PDA1

  • Pda

  • Ductus Arteriosus, Patent

  • Patent Ductus Arteriosus, Susceptibility To

  • Patent Ductus Botalli

  • Patency Of The Ductus Arteriosus

  • Patent Ductus Arteriosus Familial

  • Ductus Arteriosus Patent

  • Patent Ductus Arteriosus - Persisting Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11377 PTGER3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20586 Ptger3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27094 Ptger3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PTGER3 VGNC VGNC:33503
Rattus norvegicus PTGER3 RGD RGD:3435
Mus musculus PTGER3 MGD MGI:97795
Felis catus PTGER3 VGNC VGNC:69141
Macaca mulatta PTGER3 VGNC VGNC:76469
Others PTGER3 NCBI