SULF2 - sulfatase 2 Gene

Also Known as HSULF-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55959

About SULF2

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:47,657,406-47,786,627 (from NCBI)

This gene has 14 transcripts (splice variants), 209 orthologues and 16 paralogues. Ubiquitous expression in ovary (RPKM 36.9), endometrium (RPKM 36.6) and 24 other tissues.

Summary

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]

SULF2 Products (11)

mRNA Protein Name
NM_001161841.2 NP_001155313.1 extracellular sulfatase Sulf-2 isoform a precursor
NM_001387048.1 NP_001373977.1 extracellular sulfatase Sulf-2 isoform a precursor
NM_001387049.1 NP_001373978.1 extracellular sulfatase Sulf-2 isoform a precursor
NM_001387050.1 NP_001373979.1 extracellular sulfatase Sulf-2 isoform c precursor
NM_001387051.1 NP_001373980.1 extracellular sulfatase Sulf-2 isoform d precursor
NM_001387052.1 NP_001373981.1 extracellular sulfatase Sulf-2 isoform e precursor
NM_001387053.1 NP_001373982.1 extracellular sulfatase Sulf-2 isoform e precursor
NM_001387054.1 NP_001373983.1 extracellular sulfatase Sulf-2 isoform e precursor
NM_001387055.1 NP_001373984.1 extracellular sulfatase Sulf-2 isoform e precursor
NM_018837.4 NP_061325.1 extracellular sulfatase Sulf-2 isoform a precursor
NM_198596.3 NP_940998.2 extracellular sulfatase Sulf-2 isoform b precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N-acetylglucosamine-6-sulfatase activity IDA
IDA: Inferred from direct assay
18687675 GOA
enables N-acetylglucosamine-6-sulfatase activity IMP
IMP: Inferred from mutant phenotype
19520866 GOA
enables arylsulfatase activity IDA
IDA: Inferred from direct assay
12368295 GOA
enables arylsulfatase activity IMP
IMP: Inferred from mutant phenotype
19520866 GOA
Biological Process GO Annotation Evidence References Source
involved in heparan sulfate proteoglycan metabolic process IDA
IDA: Inferred from direct assay
18687675 GOA
involved in positive regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
19520866 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
12368295 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18687675 GOA
located in extracellular region IMP
IMP: Inferred from mutant phenotype
30788513 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SULF2 Protein Structure

Sulfatase

Sulfatase: Sulfatase (44 - 375)

DUF3740

DUF3740: Sulfatase protein (528 - 664)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 870 a.a.
Protein Preferred Names Protein Names

extracellular sulfatase Sulf-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14012 SULF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20108 Sulf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26612 Sulf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SULF2 VGNC VGNC:46975
Felis catus SULF2 VGNC VGNC:65834
Macaca mulatta SULF2 VGNC VGNC:78179
Mus musculus SULF2 MGD MGI:1919293
Rattus norvegicus SULF2 RGD RGD:1305078
Bos taurus SULF2 VGNC VGNC:35466
Others SULF2 NCBI