NGB - neuroglobin Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58157

About NGB

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:77,265,483-77,271,206 (from NCBI)

This gene has 1 transcript (splice variant) and 180 orthologues. Biased expression in adrenal (RPKM 4.2), brain (RPKM 1.8) and 3 other tissues.

Summary

This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among Other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]

NGB Products (1)

mRNA Protein Name
NM_021257.4 NP_067080.1 neuroglobin

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables GDP-dissociation inhibitor activity IDA
IDA: Inferred from direct assay
12860983 GOA
enables nitrite reductase activity IDA
IDA: Inferred from direct assay
21296891 GOA
enables oxygen binding IDA
IDA: Inferred from direct assay
11029004 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IMP
IMP: Inferred from mutant phenotype
18302932 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NGB Protein Structure

Globin

Globin: Globin (7 - 113)

  • 0
  • 100
  • 151 a.a.
Protein Preferred Names Protein Names

neuroglobin

NGB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NGB Q9NPG2 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
NGB Q9NPG2 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
NGB Q9NPG2 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra
NGB Q9NPG2 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra
NGB Q9NPG2 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Prey Pooling
32296183
Intra
NGB Q9NPG2 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Array
32296183
Intra
NGB Q9NPG2 MEI4 Homo sapiens A8MW99
Y2H Prey Pooling
32296183
Intra
NGB Q9NPG2 MEI4 Homo sapiens A8MW99
Y2H Array
32296183
Intra
NGB Q9NPG2 VAC14 Homo sapiens Q08AM6
Y2H Array
25416956
Intra
NGB Q9NPG2 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
Intra
NGB Q9NPG2 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
Intra
NGB Q9NPG2 L3MBTL3 Homo sapiens Q96JM7
Y2H Prey Pooling
25416956
Intra
NGB Q9NPG2 L3MBTL3 Homo sapiens Q96JM7
Y2H Array
25416956
Intra
NGB Q9NPG2 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
NGB Q9NPG2 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
NGB Q9NPG2 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
NGB Q9NPG2 BTBD2 Homo sapiens Q9BX70
Y2H Prey Pooling
32296183
Intra
NGB Q9NPG2 BTBD2 Homo sapiens Q9BX70
Y2H Array
32296183
Intra
NGB Q9NPG2 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
32296183
Intra
NGB Q9NPG2 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
32296183
Intra
NGB Q9NPG2 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
NGB Q9NPG2 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
NGB Q9NPG2 TDO2 Homo sapiens P48775
Validated Y2H
25416956
Intra
NGB Q9NPG2 TDO2 Homo sapiens P48775
Y2H Array
32296183
Intra
NGB Q9NPG2 TDO2 Homo sapiens P48775
Y2H Prey Pooling
25416956
Intra
NGB Q9NPG2 TDO2 Homo sapiens P48775
Y2H Prey Pooling
32296183
Intra
NGB Q9NPG2 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
25416956
Intra
NGB Q9NPG2 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
32296183
Intra
NGB Q9NPG2 IHO1 Homo sapiens Q8IYA8
Y2H Array
32296183
Intra
NGB Q9NPG2 GATAD2B Homo sapiens Q8WXI9
Y2H Array
32296183
Intra
NGB Q9NPG2 GATAD2B Homo sapiens Q8WXI9
Y2H Prey Pooling
32296183
Intra
NGB Q9NPG2 C1orf94 Homo sapiens Q6P1W5
Y2H Prey Pooling
25416956
Intra
NGB Q9NPG2 C1orf94 Homo sapiens Q6P1W5
Validated Y2H
25416956
Intra
NGB Q9NPG2 C1orf94 Homo sapiens Q6P1W5
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

NGB Antibodies

Cat. No. Product Name Application Reactivity
HY-P84815 NGB Antibody (YA4512) WB, FC, ELISA Human, Mouse, Rat
HY-P84815A NGB Antibody (YA4512)(PBS only) WB, FC, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Ischemia

  • Acute Coronary Syndrome
Stroke, Ischemic

  • Cerebral Infarction

  • Stroke

  • Ischemic Stroke

  • Cerebrovascular Accident

  • Cerebral Infarction, Susceptibility To

  • Stroke, Ischemic, Susceptibility To

  • Cerebral Infarct

  • Ischemic Stroke, Susceptibility To

  • Stroke, Susceptibility To

  • Cva - Cerebral Infarction

  • ISCHSTR

  • Ischemic Cerebrovascular Accident
Intracranial Berry Aneurysm

  • Familial Aneurysmal Subarachnoid Hemorrhage

  • Familial Berry Aneurysm

  • Familial Intracranial Saccular Aneurysm

  • Saccular Cerebral Aneurysm

  • Aneurysm, Intracranial Berry

  • Aneurysmal Subarachnoid Hemorrhage

  • Aneurysm, Intracranial Berry, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12697 NGB 2904 Antagonist 99.76% Unkown
HY-12697A NGB 2904 hydrochloride Antagonist / Unkown
HY-RS05911 GTPBP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09274 NGB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NGB MGD MGI:2151886
Canis familiaris NGB VGNC VGNC:43793
Macaca mulatta NGB VGNC VGNC:84408
Bos taurus NGB VGNC VGNC:32058
Rattus norvegicus NGB RGD RGD:621461
Others NGB NCBI