DDX31 - DEAD-box helicase 31 Gene

Also Known as PPP1R25

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64794

About DDX31

Cytogenetic location: 9q34.13 Genomic coordinates (GRCh38): 9:132,592,997-132,669,983 (from NCBI)

This gene has 5 transcripts (splice variants), 186 orthologues and 38 paralogues. Ubiquitous expression in thyroid (RPKM 4.3), ovary (RPKM 2.4) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2016]

DDX31 Products (7)

mRNA Protein Name
NM_001322340.2 NP_001309269.2 probable ATP-dependent RNA helicase DDX31 isoform 3
NM_001322341.2 NP_001309270.1 probable ATP-dependent RNA helicase DDX31 isoform 4
NM_001322342.1 NP_001309271.1 probable ATP-dependent RNA helicase DDX31 isoform 5
NM_001322343.1 NP_001309272.1 probable ATP-dependent RNA helicase DDX31 isoform 6
NM_001322344.2 NP_001309273.2 probable ATP-dependent RNA helicase DDX31 isoform 7
NM_022779.9 NP_073616.7 probable ATP-dependent RNA helicase DDX31 isoform 1
NM_138620.2 NP_619526.2 probable ATP-dependent RNA helicase DDX31 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23019224 GOA
Biological Process GO Annotation Evidence References Source
involved in ribosome biogenesis IMP
IMP: Inferred from mutant phenotype
23019224 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
23019224 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX31 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (255 - 431)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (553 - 602)

DUF4217

DUF4217: Domain of unknown function (DUF4217) (642 - 681)

  • 0
  • 200
  • 400
  • 600
  • 778 a.a.
Protein Preferred Names Protein Names

probable ATP-dependent RNA helicase DDX31

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 31

DDX31 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DDX31 Q9H8H2 SRP14 Homo sapiens P37108
Anti Tag CoIP
33961781
Intra
DDX31 Q9H8H2 SRP14 Homo sapiens P37108
Crosslink
30021884
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Skin Sarcoma

  • Cutaneous Sarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03643 DDX31 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00510 AK8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DDX31 MGD MGI:2682639
Felis catus DDX31 VGNC VGNC:61405
Rattus norvegicus DDX31 RGD RGD:1304895
Bos taurus DDX31 VGNC VGNC:27963
Macaca mulatta DDX31 VGNC VGNC:71631
Others DDX31 NCBI