LSD1-IN-34
LSD1-IN-34 (Compound 7d) is the orally active inhibitor for Lysine-specific demethylase (LSD) and monoamine oxidase (MAO), with IC50 of 4.51 and 18.46 nM, for LSD1 and MAO A. LSD1-IN-34 inhibits the Ang II-induced neonatal rat myocardial fibroblasts (NRCFs) activation, without significant toxicity (20 μM). LSD1-IN-34 inhibits TGFβ/Smad signaling pathway, and ameliorates heart failure in mice. LSD1-IN-34 exhibits good pharmacokinetic characteristics in rats.
For research use only. We do not sell to patients.
- CAS No.: 3048029-74-6
- Formula: C19H17ClF2N4O2
- Molecular Weight:406.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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LSD1 4.51 nM (IC50) |
MAO-A 18.46 nM (IC50) |
MAO-B 8481.67 nM (IC50) |
Chemical Information
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CAS No. 3048029-74-6
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Molecular Weight 406.81
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Formula C19H17ClF2N4O2
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SMILES
FC1=CC([C@H]2[C@H](NCC3=CN(C4=CC=C(OCO5)C5=C4)N=N3)C2)=CC=C1F.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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