3048029-74-6
Chemical Structure
LSD1-IN-34
- CAS No.: 3048029-74-6
- Formula:C19H17ClF2N4O2
- Molecular Weight:406.81
InChIKey: YILMBCAVVIBYJY-SQQLFYIASA-N
SMILES: FC1=CC([C@H]2[C@H](NCC3=CN(C4=CC=C(OCO5)C5=C4)N=N3)C2)=CC=C1F.Cl
Biological Activity: LSD1-IN-34 (Compound 7d) is the orally active inhibitor for Lysine-specific demethylase (LSD) and monoamine oxidase (MAO), with IC50 of 4.51 and 18.46 nM, for LSD1 and MAO A. LSD1-IN-34 inhibits the Ang II-induced neonatal rat myocardial fibroblasts (NRCFs) activation, without significant toxicity (20 μM). LSD1-IN-34 inhibits TGFβ/Smad signaling pathway, and ameliorates heart failure in mice. LSD1-IN-34 exhibits good pharmacokinetic characteristics in rats[1].
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LSD1-IN-34 | LSD1-IN-34 (Compound 7d) is the orally active inhibitor for Lysine-specific demethylase (LSD) and monoamine oxidase (MAO), with IC50 of 4.51 and 18.46 nM, for LSD1 and MAO A. LSD1-IN-34 inhibits the Ang II-induced neonatal rat myocardial fibroblasts (NRCFs) activation, without significant toxicity (20 μM). LSD1-IN-34 inhibits TGFβ/Smad signaling pathway, and ameliorates heart failure in mice. LSD1-IN-34 exhibits good pharmacokinetic characteristics in rats. | |||||||||||||||||||||
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Keywords
