Lamb2 - laminin, beta 2 Gene

Also Known as Lams; npht; Lamb-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16779

Summary

Enables Integrin binding activity. Acts upstream of or within several processes, including metanephric glomerulus development; neurogenesis; and visual perception. Located in basement membrane and neuromuscular junction. Part of laminin-3 complex. Is active in synaptic cleft. Is expressed in several structures, including Reichert's membrane; alimentary system; brain; decidua; and liver. Used to study Pierson syndrome and nephrosis. Human ortholog(s) of this gene implicated in Pierson syndrome and nephrotic syndrome type 5. Orthologous to human LAMB2 (laminin subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Lamb2 Products (3)

mRNA Protein Name
NM_001411228.1 NP_001398157.1 laminin subunit beta-2 precursor
NM_001411229.1 NP_001398158.1 laminin subunit beta-2 precursor
NM_008483.4 NP_032509.2 laminin subunit beta-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IPI
IPI: Inferred from physical interaction
20566382 MGI
enables structural constituent of synapse-associated extracellular matrix IDA
IDA: Inferred from direct assay
17189701 MGI
enables structural constituent of synapse-associated extracellular matrix IEP
IEP: Inferred from expression pattern
17189701 MGI
enables structural constituent of synapse-associated extracellular matrix IMP
IMP: Inferred from mutant phenotype
17189701 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Schwann cell development IDA
IDA: Inferred from direct assay
9641682 MGI
acts upstream of or within astrocyte development IGI
IGI: Inferred from genetic interaction
19907020 MGI
acts upstream of or within axon extension involved in regeneration IMP
IMP: Inferred from mutant phenotype
9396756 MGI
acts upstream of or within axon guidance IGI
IGI: Inferred from genetic interaction
19295126 MGI
acts upstream of or within cell morphogenesis IGI
IGI: Inferred from genetic interaction
19907020 MGI
acts upstream of or within metanephric glomerular basement membrane development IMP
IMP: Inferred from mutant phenotype
7670489 MGI
acts upstream of or within metanephric podocyte development IMP
IMP: Inferred from mutant phenotype
16886065 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
7885444 MGI
acts upstream of or within neuron projection development IDA
IDA: Inferred from direct assay
20566382 MGI
acts upstream of or within retina development in camera-type eye IGI
IGI: Inferred from genetic interaction
19907020 MGI
acts upstream of or within synapse organization IMP
IMP: Inferred from mutant phenotype
17189701 MGI
acts upstream of or within visual perception IGI
IGI: Inferred from genetic interaction
19907020 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
7670489 MGI
part of laminin complex IDA
IDA: Inferred from direct assay
8034675 MGI
part of laminin-3 complex IDA
IDA: Inferred from direct assay
20566382 MGI
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
9396756 MGI
located in synapse IDA
IDA: Inferred from direct assay
17189701 MGI
is active in synaptic cleft IDA
IDA: Inferred from direct assay
9396756 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

laminin subunit beta-2

  • Laminin S

  • S-LAM beta

  • S-laminin subunit beta

  • laminin-11 subunit beta

  • laminin-14 subunit beta

  • laminin-15 subunit beta

  • laminin-3 subunit beta

  • laminin-4 subunit beta

  • laminin-7 subunit beta

  • laminin-9 subunit beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07503 LAMB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07506 LAMC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07716 LMNB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20440 Lamc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21625 Lamb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28143 Lamb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lamb2 NCBI NCBI:3913