PAM - Pam peptidylglycine alpha-amidating monooxygenase Gene

Also Known as PHM

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25508

Summary

Enables several functions, including metal ion binding activity; peptidylamidoglycolate lyase activity; and peptidylglycine monooxygenase activity. Involved in several processes, including animal organ development; fatty acid primary amide biosynthetic process; and peptide amidation. Located in several cellular components, including perikaryon; secretory granule membrane; and trans-Golgi network. Biomarker of hypothyroidism. Orthologous to human PAM (peptidylglycine alpha-amidating monooxygenase). [provided by Alliance of Genome Resources, Apr 2022]

PAM Products (1)

mRNA Protein Name
NM_013000.3 NP_037132.2 peptidylglycine alpha-amidating monooxygenase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
19604476 RGD
enables copper ion binding IDA
IDA: Inferred from direct assay
10504734 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
11395514 RGD
enables peptidylamidoglycolate lyase activity IDA
IDA: Inferred from direct assay
10079066 RGD
enables peptidylglycine monooxygenase activity IDA
IDA: Inferred from direct assay
10079066 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8910496 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
8910496 RGD
enables zinc ion binding IDA
IDA: Inferred from direct assay
19604476 RGD
Biological Process GO Annotation Evidence References Source
involved in fatty acid primary amide biosynthetic process IDA
IDA: Inferred from direct assay
10079066 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
9441675 RGD
involved in lactation IEP
IEP: Inferred from expression pattern
16448835 RGD
involved in limb development IEP
IEP: Inferred from expression pattern
9441675 RGD
involved in long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
8660675 RGD
involved in maternal process involved in female pregnancy IEP
IEP: Inferred from expression pattern
9441675 RGD
involved in ovulation cycle process IEP
IEP: Inferred from expression pattern
9618561 RGD
involved in peptide amidation IDA
IDA: Inferred from direct assay
2999151 RGD
involved in peptide metabolic process IDA
IDA: Inferred from direct assay
18818385 RGD
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
11251076 RGD
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20573687 RGD
involved in response to copper ion IEP
IEP: Inferred from expression pattern
15629125 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
9618561 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
10347250 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
18818385 RGD
involved in response to pH IDA
IDA: Inferred from direct assay
11395514 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
10347250 RGD
involved in toxin metabolic process IDA
IDA: Inferred from direct assay
12721493 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
15905171 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
16448835 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
20202202 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
8910496 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
8663411 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
15539631 RGD
located in trans-Golgi network IDA
IDA: Inferred from direct assay
20573687 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peptidylglycine alpha-amidating monooxygenase

  • basic salivary proline-rich protein 4-like

  • peptidyl-glycine alpha-amidating monooxygenase

Orthologs Information

Species Symbol Source ID
Homo sapiens PAM NCBI NCBI:5066