Insm1 - insulinoma-associated 1 Gene

Also Known as IA-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53626

Summary

Predicted to enable several functions, including DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and cyclin binding activity. Involved in several processes, including glandular epithelial cell differentiation; nervous system development; and norepinephrine biosynthetic process. Acts upstream of or within positive regulation of cell migration; positive regulation of cell population proliferation; and type B pancreatic cell development. Located in nucleus. Is expressed in several structures, including adrenal gland; branchial arch; gut; nervous system; and sensory organ. Orthologous to human INSM1 (INSM transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]

Insm1 Products (1)

mRNA Protein Name
NM_016889.4 NP_058585.2 insulinoma-associated protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12079283 MGI
Biological Process GO Annotation Evidence References Source
involved in adrenal chromaffin cell differentiation IMP
IMP: Inferred from mutant phenotype
18094025 MGI
acts upstream of cell migration IMP
IMP: Inferred from mutant phenotype
25053427 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
25053427 MGI
acts upstream of or within endocrine pancreas development IMP
IMP: Inferred from mutant phenotype
16511571 MGI
acts upstream of or within endocrine system development IMP
IMP: Inferred from mutant phenotype
16951258 MGI
involved in noradrenergic neuron development IMP
IMP: Inferred from mutant phenotype
18094025 MGI
involved in norepinephrine biosynthetic process IMP
IMP: Inferred from mutant phenotype
18094025 MGI
involved in pancreatic A cell differentiation IDA
IDA: Inferred from direct assay
16511571 MGI
acts upstream of or within pancreatic A cell differentiation IMP
IMP: Inferred from mutant phenotype
16511571 MGI
involved in positive regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
18094025 MGI
acts upstream of or within positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
25053427 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
25053427 MGI
involved in positive regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
18094025 MGI
involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18094025 MGI
involved in sympathetic ganglion development IMP
IMP: Inferred from mutant phenotype
18094025 MGI
acts upstream of or within type B pancreatic cell development IMP
IMP: Inferred from mutant phenotype
16951258 MGI
involved in type B pancreatic cell differentiation IDA
IDA: Inferred from direct assay
16511571 MGI
acts upstream of or within type B pancreatic cell differentiation IMP
IMP: Inferred from mutant phenotype
16511571 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12079283 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

insulinoma-associated protein 1

  • insulinoma-associated protein (IA-1)

  • zinc finger protein IA-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-183067 TAS1440 98.03% Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183067A TAS1440 benzoate / Unkown
HY-RS06844 INSM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20042 Insm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26545 Insm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Insm1 NCBI NCBI:3642