INSM1 - INSM transcriptional repressor 1 Gene

Also Known as IA1; IA-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3642

About INSM1

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:20,368,104-20,370,949 (from NCBI)

This gene has 1 transcript (splice variant), 210 orthologues and 1 paralogue.

Summary

Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. [provided by RefSeq, Jul 2008]

INSM1 Products (1)

mRNA	Protein	Name
NM_002196.3	NP_002187.1	insulinoma-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11842116	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16569215	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11842116	GOA
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	16569215	GOA
enables cyclin binding	IPI IPI: Inferred from physical interaction	16569215	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	16569215	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	23721412	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	19124461	GOA
involved in negative regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	19124461	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11842116	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	19124461	GOA
involved in regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	19124461	GOA
involved in transdifferentiation	IDA IDA: Inferred from direct assay	16511571	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of transcription repressor complex	IDA IDA: Inferred from direct assay	16569215	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INSM1 Protein Structure

zf-C2H2

zf-C2H2_4

zf-C2H2

0
100
200
300
400
510 a.a.

Protein Preferred Names	Protein Names
insulinoma-associated protein 1	insulinoma-associated 1

Related Diseases

Diseases	Alias
Insulinoma	Islet Cell Adenoma Insulin-Producing Tumor Of Islet Cells Adenoma Islet Cell Islet Cell Tumor Experimental Organism Islet Cell Adenoma Neoplasm
Neuroendocrine Tumor	Neuroendocrine Neoplasm Neuroendocrine Tumors Carcinoma, Neuroendocrine
Early Invasive Cervical Adenocarcinoma
Microinvasive Cervical Squamous Cell Carcinoma	Early Invasive Cervical Squamous Cell Carcinoma
Papillary Squamous Carcinoma	Papillary Epidermoid Carcinoma Papillary Squamous Cell Carcinoma
Urinary Bladder Small Cell Neuroendocrine Carcinoma	Small Cell Neuroendocrine Carcinoma Of The Urinary Bladder Small Cell/Neuroendocrine Carcinoma Of Urinary Bladder
Uterus Carcinoma In Situ
Ethmoid Sinus Cancer	Malignant Neoplasm Of Ethmoidal Sinus Malignant Tumor Of Ethmoid Sinus Malignant Tumor Of Ethmoidal Sinus Neoplasm Of Ethmoidal Sinus
Cervical Incompetence	Uterine Cervical Incompetence
Hemometra	Hematometra
Cervix Uteri Carcinoma In Situ	Carcinoma In Situ Of Cervix Carcinoma In Situ Of Uterine Cervix Cervical Intraepithelial Neoplasia Carcinoma Of Cervix Stage 0 Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia Cervix Ca In Situ Cin Iii Cin Iii - Carcinoma In Situ Of Cervix Cin Iii - Severe Dyskaryosis Severe Dysplasia Of Cervix Severe Dysplasia Of The Cervix Uteri Squamous Intraepithelial Neoplasia, Grade Iii Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7
Vaginal Cancer	Malignant Neoplasm Of Vagina Vaginal Neoplasms Malignant Tumor Of Vagina Malignant Vaginal Tumor Neoplasm Of Vagina Vagina Neoplasm Vaginal Tumor Vaginal Carcinoma Vaginal Malignant Epithelial Tumor Vaginal Neoplasm Malignant Vaginal Neoplasm Vagina Carcinoma Vaginal Neoplasia Cancer Of Vagina Malignant Tumour Of Vagina Carcinoma Of Vagina Primary Malignant Neoplasm Of Vagina Vagina Wall Cancer Vaginal Wall Cancer
Adenocarcinoma In Situ
Isthmus Cancer
Sweat Gland Cancer	Sweat Gland Carcinoma Malignant Neoplasm Of Sweat Gland Malignant Tumor Of The Sweat Gland Carcinoma Of The Sweat Gland Primary Malignant Neoplasm Of Sweat Gland Sweat Gland Neoplasms
Lymphocele	Lymph Cyst Lymphocele Adverse Event
Bleeding Disorder, Platelet-Type, 17	Platelet-Type Bleeding Disorder 17 BDPLT17 Thrombasthenia-Thrombocytopenia, Hereditary Hereditary Thrombasthenia-Thrombocytopenia Autosomal Dominant Macrothrombocytopenia Gfi1b-Related Autosomal Dominant Platelet Disorder Gfi1b-Related Bleeding Disorder, Platelet Type 17
Small Cell Cancer Of The Lung	Small Cell Lung Cancer Small Cell Lung Carcinoma Sclc Small-Cell Cancer Of Lung Lung Small Cell Carcinoma Sclc1 Sccl Cancer, Lung, Small Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Hidrocystoma	Apocrine Cystadenoma Eccrine Hidrocystoma Eccrine Cystadenoma Eccrine Hidrocystoma Of Skin Apocrine Adenoma
Pulmonary Neuroendocrine Tumor	Neuroendocrine Neoplasm Of Lung
Large Cell Neuroendocrine Carcinoma
Fallopian Tube Endometrioid Adenocarcinoma	Endometrioid Carcinoma Of The Fallopian Tube Fallopian Tube Endometrioid Cancer Fallopian Tube Endometrioid Neoplasm Fallopian Tube Endometrioid Tumor
Adenosquamous Carcinoma	Adenosquamous Cell Carcinoma Mixed Adenocarcinoma And Squamous Carcinoma Carcinoma Adenosquamous Carcinoma, Adenosquamous
Lung Large Cell Carcinoma	Large Cell Carcinoma Of Lung Large Cell Lung Carcinoma Large Cell Lung Cancer
Pulmonary Large Cell Neuroendocrine Carcinoma	Large Cell Lung Neuroendocrine Carcinoma
Basaloid Squamous Cell Carcinoma	Basaloid Carcinoma
Endocervical Carcinoma	Carcinoma Of Endocervix Carcinoma Of The Endocervix
Cervical Adenocarcinoma	Adenocarcinoma Cervix Uteri Adenocarcinoma Of Cervix Adenocarcinoma Of The Uterine Cervix Adenocarcinoma Of The Cervix Uteri
Chronic Cervicitis
Paranasal Sinus Cancer	Paranasal Sinus Adenoid Cystic Carcinoma Paranasal Sinus Mucoepidermoid Carcinoma Paranasal Sinus Squamous Cell Carcinoma Paranasal Sinus Neoplasms Adenoid Cystic Carcinoma Of Accessory Sinus Adenoid Cystic Carcinoma Of Paranasal Sinus Epidermoid Carcinoma Of The Paranasal Sinus Mucoepidermoid Carcinoma Of Accessory Sinus Paranasal Sinus Adenocarcinoma Squamous Cell Carcinoma Of Paranasal Sinus Paranasal Sinus Neoplasm Adenocarcinoma Of Accessory Sinus
Cervix Carcinoma	Cancer Of Cervix Carcinoma Of Cervix Carcinoma Cervix Uteri Carcinoma Of The Cervix Uteri
Sebaceous Gland Disease	Sebaceous Gland Anomaly Sebaceous Gland Diseases
Endocervical Adenocarcinoma	Endocervical Carcinoma
Pancreatic Cystadenoma	Cystadenoma Of Pancreas
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
In Situ Carcinoma	Carcinoma In Situ
Pre-Malignant Neoplasm
Chondrosarcoma, Extraskeletal Myxoid	Extraskeletal Myxoid Chondrosarcoma Emc Myxoid Extraosseous Chondrosarcoma
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-183067	TAS1440		98.03%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-183067A	TAS1440 benzoate		/	Unkown
HY-RS06844	INSM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20042	Insm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26545	Insm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	INSM1	MGD	MGI:1859980
Bos taurus	INSM1	VGNC	VGNC:30220
Macaca mulatta	INSM1	VGNC	VGNC:84917
Rattus norvegicus	INSM1	RGD	RGD:6486258
Others	INSM1	NCBI