CLRN2 - clarin 2 Gene

Also Known as DFNB117

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 645104

About CLRN2

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:17,515,165-17,527,104 (from NCBI)

This gene has 1 transcript (splice variant), 195 orthologues, 2 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

This gene belongs to the clarin family of genes. The clarins appear to belong to a large superfamily of small integral membrane glycoproteins with four transmembrane domains. The exact function of this gene is unknown. [provided by RefSeq, Oct 2008]

CLRN2 Products (1)

mRNA	Protein	Name
NM_001079827.2	NP_001073296.1	clarin-2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	33496845	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLRN2 Protein Structure

PMP22_Claudin

0
100
200
232 a.a.

Protein Preferred Names	Protein Names
clarin-2

CLRN2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CLRN2	A0PK11	NEMP1	Homo sapiens	O14524-2	Validated Y2H	32296183
Intra	CLRN2	A0PK11	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	CLRN2	A0PK11	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	LRRC25	Homo sapiens	Q8N386	Y2H Array	32296183
Intra	CLRN2	A0PK11	LRRC25	Homo sapiens	Q8N386	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	LRRC25	Homo sapiens	Q8N386	Validated Y2H	32296183
Intra	CLRN2	A0PK11	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Array	32296183
Intra	CLRN2	A0PK11	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	CLEC2D	Homo sapiens	Q9UHP7-3	Validated Y2H	32296183
Intra	CLRN2	A0PK11	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	STOM	Homo sapiens	P27105	Validated Y2H	32296183
Intra	CLRN2	A0PK11	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	CLRN2	A0PK11	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	CLRN2	A0PK11	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	CLRN2	A0PK11	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	CLRN2	A0PK11	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	CLRN2	A0PK11	CLDN5	Homo sapiens	O00501	Validated Y2H	32296183
Intra	CLRN2	A0PK11	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
Intra	CLRN2	A0PK11	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	TEX29	Homo sapiens	Q8N6K0	Y2H Array	32296183
Intra	CLRN2	A0PK11	TEX29	Homo sapiens	Q8N6K0	Validated Y2H	32296183
Intra	CLRN2	A0PK11	TEX29	Homo sapiens	Q8N6K0	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	ARL6IP6	Homo sapiens	Q8N6S5	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	ARL6IP6	Homo sapiens	Q8N6S5	Validated Y2H	32296183
Intra	CLRN2	A0PK11	ARL6IP6	Homo sapiens	Q8N6S5	Y2H Array	32296183
Intra	CLRN2	A0PK11	SIT1	Homo sapiens	Q9Y3P8	Validated Y2H	32296183
Intra	CLRN2	A0PK11	SIT1	Homo sapiens	Q9Y3P8	Y2H Array	32296183
Intra	CLRN2	A0PK11	SIT1	Homo sapiens	Q9Y3P8	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	VSIR	Homo sapiens	Q9H7M9	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	VSIR	Homo sapiens	Q9H7M9	Validated Y2H	32296183
Intra	CLRN2	A0PK11	VSIR	Homo sapiens	Q9H7M9	Y2H Array	32296183
Intra	CLRN2	A0PK11	KLRC1	Homo sapiens	P26715	Validated Y2H	32296183
Intra	CLRN2	A0PK11	KLRC1	Homo sapiens	P26715	Y2H Array	32296183
Intra	CLRN2	A0PK11	KLRC1	Homo sapiens	P26715	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 117	DFNB117 Deafness, Autosomal Recessive, 117
Usher Syndrome, Type Iiia	Usher Syndrome Type 3 Ush3 Usher Syndrome Type 3a USH3A Usher Syndrome, Type Iii Usher Syndrome, Type 3 Usher Syndrome, Type 3a Usher Syndrome Type Iiia Usher Syndrome 3a Usher'S Syndrome Type 3 Usher Syndrome Iii Usher Syndrome Type Iii
Acute Hemorrhagic Leukoencephalitis	Ahl Acute Haemorrhagic Leucoencephalitis Of Weston Hurst Leukoencephalitis, Acute Hemorrhagic Acute Hemorrhagic Encephalomyelitis Acute Necrotizing Hemorrhagic Leukoencephalitis Weston-Hurst Syndrome Ahle Acute Haemorrhagic Leucoencephalitis Hurst Disease Acute Haemorrhagic Leukoencephalitis, Postimmunization Or Postvaccinal Postimmunization Or Postvaccinal Leukoencephalopathy
Deafness, Autosomal Recessive 111	DFNB111 Autosomal Recessive Nonsyndromic Deafness 111 Autosomal Recessive Deafness 111 Deafness, Autosomal Recessive, 111
Deafness, Autosomal Recessive 61	DFNB61 Autosomal Recessive Nonsyndromic Deafness 61 Autosomal Recessive Deafness 61 Deafness, Autosomal Recessive, 61 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 61 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 61 Deafness, Autosomal Recessive, Type 61
Deafness, Autosomal Recessive 8	Neurosensory Nonsyndromic Recessive Deafness 8 DFNB8 Dfnb10 Deafness, Autosomal Recessive 10 Deafness, Childhood-Onset Neurosensory, Autosomal Recessive 8 Nsrd8 Autosomal Recessive Nonsyndromic Deafness 8 Deafness, Autosomal Recessive 8/10 Autosomal Recessive Deafness 10 Autosomal Recessive Deafness 8 Childhood-Onset Neurosensory Autosomal Recessive Deafness 8 Nrsd8 Deafness, Autosomal Recessive, 8 Childhood-Onset Neurosensory Deafness Autosomal Recessive 8 Deafness Autosomal Recessive 10 Deafness Autosomal Recessive 8/10 Deafness Neurosensory Autosomal Recessive 8 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 8 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 8 Deafness, Autosomal Recessive, Type 8/10
Deafness, Autosomal Recessive 28	DFNB28 Autosomal Recessive Nonsyndromic Deafness 28 Autosomal Recessive Deafness 28 Deafness, Autosomal Recessive, 28 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 28 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 28 Deafness, Autosomal Recessive, Type 28
Deafness, Autosomal Dominant 65	DFNA65 Autosomal Dominant Nonsyndromic Deafness 65 Autosomal Dominant Deafness 65 Deafness, Autosomal Dominant, 65 Deafness, Autosomal Dominant, Type 65
Petroclival Meningioma
Deafness, Autosomal Recessive 86	DFNB86 Autosomal Recessive Nonsyndromic Deafness 86 Autosomal Recessive Deafness 86 Deafness, Autosomal Recessive, 86 Deafness, Nonsyndromic, Autosomal Recessive, Type 86
Deafness, Autosomal Dominant 3a	DFNA3A Autosomal Dominant Nonsyndromic Deafness 3a Autosomal Dominant Deafness 3a Deafness, Autosomal Dominant, 3a Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 3a Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 3a Deafness, Autosomal Dominant, Type 3a
Melnick-Needles Syndrome	MNS Melnick-Needles Osteodysplasty Osteodysplasty Of Melnick And Needles Osteochondrodysplasias
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Frontometaphyseal Dysplasia	Fmd Dysplasia, Frontometaphyseal
Usher Syndrome	Deafness-Retinitis Pigmentosa Syndrome Dystrophia Retinae Pigmentosa-Dysostosis Syndrome Graefe-Usher Syndrome Hallgren Syndrome Usher'S Syndrome Retinitis Pigmentosa-Deafness Syndrome Retinitis Pigmentosa-Hearing Loss Syndrome Ush Usher Syndromes
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02837	CLRN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CLRN2	VGNC	VGNC:27463
Rattus norvegicus	CLRN2	RGD	RGD:1591112
Mus musculus	CLRN2	MGD	MGI:3646230
Felis catus	CLRN2	VGNC	VGNC:60977
Macaca mulatta	CLRN2	VGNC	VGNC:71380
Canis familiaris	CLRN2	VGNC	VGNC:39360
Others	CLRN2	NCBI