Hcar2 - hydroxycarboxylic acid receptor 2 Gene

Also Known as HM74; Pumag; Niacr1; PUMA-G; mHM74b; Gpr109a; Gpr109b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 80885

About Hcar2

Chromosome 5: 124,001,633-124,003,562 reverse strand.GRCm39:CM000998.3

This gene has 1 transcript (splice variant), 164 orthologues, 13 paralogues and is associated with 5 phenotypes.

Summary

Enables G protein-coupled receptor activity; GTP binding activity; and purinergic nucleotide receptor activity. Involved in G protein-coupled receptor signaling pathway. Is integral component of membrane. Is active in membrane. Is expressed in embryo. Orthologous to several human genes including HCAR3 (hydroxycarboxylic acid receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Hcar2 Products (1)

mRNA Protein Name
NM_030701.3 NP_109626.1 hydroxycarboxylic acid receptor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
19047060 MGI
enables GTP binding IDA
IDA: Inferred from direct assay
12646212 MGI
enables purinergic nucleotide receptor activity IDA
IDA: Inferred from direct assay
12646212 MGI
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
19047060 MGI
Cellular Component GO Annotation Evidence References Source
is active in membrane IDA
IDA: Inferred from direct assay
19047060 MGI
located in membrane IDA
IDA: Inferred from direct assay
12646212 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hcar2 Protein Structure

7tmA_HCAR1-3

7tmA_HCAR1-3: cd15201 (24 - 301)

7tmA_HCAR1-3

7tmA_HCAR1-3: cd15201 (25 - 51)

7tmA_HCAR1-3

7tmA_HCAR1-3: cd15201 (58 - 83)

7tmA_HCAR1-3

7tmA_HCAR1-3: cd15201 (96 - 126)

7tmA_HCAR1-3

7tmA_HCAR1-3: cd15201 (138 - 160)

7tmA_HCAR1-3

7tmA_HCAR1-3: cd15201 (181 - 210)

7tmA_HCAR1-3

7tmA_HCAR1-3: cd15201 (220 - 250)

7tmA_HCAR1-3

7tmA_HCAR1-3: cd15201 (269 - 294)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
Protein Preferred Names Protein Names

hydroxycarboxylic acid receptor 2

  • G protein-coupled receptor 109A

  • G protein-coupled receptor 109B

  • G-protein coupled receptor 109

  • G-protein coupled receptor HM74

  • interferon-gamma inducible gene, Puma-g

  • niacin receptor 1

  • nicotinic acid receptor

  • putative seven transmembrane spanning receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-30216A Leucic acid 98.38% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hcar2 NCBI NCBI:338442