IRS4 - insulin receptor substrate 4 Gene

Also Known as CHNG9; IRS-4; PY160

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8471

About IRS4

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:108,719,946-108,736,563 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues, 2 paralogues and is associated with 85 phenotypes. Biased expression in ovary (RPKM 3.0), thyroid (RPKM 1.0) and 3 other tissues.

Summary

IRS4 encodes the Insulin Receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the Insulin Receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008]

IRS4 Products (2)

mRNA	Protein	Name
NM_001379150.1	NP_001366079.1	insulin receptor substrate 4 isoform 2
NM_003604.2	NP_003595.1	insulin receptor substrate 4 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11316748	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRS4 Protein Structure

IRS

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1257 a.a.

Protein Preferred Names	Protein Names
insulin receptor substrate 4	160 kDa phosphotyrosine protein

IRS4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IRS4	O14654	PTGES3	Homo sapiens	Q15185	Lumier	25036637
Intra	IRS4	O14654	PTGES3	Homo sapiens	Q15185	Anti Tag CoIP	25036637
Intra	IRS4	O14654	EGFR	Homo sapiens	P00533	Protein Array	16273093
Intra	IRS4	O14654	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	25036637
Intra	IRS4	O14654	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	IRS4	O14654	CRK	Homo sapiens	P46108	Pull Down	11316748
Intra	IRS4	O14654	CRK	Homo sapiens	P46108	CoIP	11316748

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hypothyroidism, Congenital, Nongoitrous, 9	CHNG9 Congenital Nongoitrous Hypothyroidism 9 Hypothyroidism, Congenital, Non-Goitrous, 9 Hypothyroidism, Congenital, Nongoitrous, Type 9
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Hypothyroidism, Central, With Testicular Enlargement	X-Linked Central Congenital Hypothyroidism With Late-Onset Testicular Enlargement CHTE Hypothyroidism, Central, And Testicular Enlargement Igsf1 Deficiency Syndrome X-Linked Central Congenital Hypothyroidism With Late-Onset Macroorchidism Central Hypothyroidism And Testicular Enlargement Hypothyroidism, Central, Testicular Enlargement
Boutonneuse Fever	Mediterranean Spotted Fever African Tick Typhus Boutonneuse Disease Conor And Bruch'S Disease Kenya Fever Kenya Tick Typhus Kenyan Tick Typhus Marseilles Fever Mediterranean Tick Fever Rickettsia Conorii Spotted Fever South African Tick-Bite Fever African Tick Bite Fever
Breast Rhabdomyosarcoma	Rhabdomyosarcoma Of The Breast
Prader-Willi Syndrome	Prader-Labhart-Willi Syndrome PWS Willi-Prader Syndrome Prader-Willi Syndrome Due To Translocation Prader-Willi Syndrome Due To Imprinting Mutation Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15 Prader Willi Syndrome Upd(15)Mat

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06919	IRS4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21358	Irs4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27877	Irs4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IRS4	MGD	MGI:1338009
Bos taurus	IRS4	VGNC	VGNC:30285
Macaca mulatta	IRS4	VGNC	VGNC:73767
Felis catus	IRS4	VGNC	VGNC:67831
Rattus norvegicus	IRS4	RGD	RGD:1562442
Canis familiaris	IRS4	VGNC	VGNC:42100
Others	IRS4	NCBI