CREB5 - cAMP responsive element binding protein 5 Gene

Also Known as CREB-5; CREBPA; CRE-BPA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9586

About CREB5

Cytogenetic location: 7p15.1-p14.3 Genomic coordinates (GRCh38): 7:28,299,321-28,825,894 (from NCBI)

This gene has 15 transcripts (splice variants), 245 orthologues and 2 paralogues. Broad expression in gall bladder (RPKM 3.3), brain (RPKM 3.0) and 22 other tissues.

Summary

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

CREB5 Products (4)

mRNA Protein Name
NM_001011666.3 NP_001011666.1 cyclic AMP-responsive element-binding protein 5 isoform delta
NM_004904.4 NP_004895.2 cyclic AMP-responsive element-binding protein 5 isoform beta
NM_182898.4 NP_878901.2 cyclic AMP-responsive element-binding protein 5 isoform alpha
NM_182899.5 NP_878902.2 cyclic AMP-responsive element-binding protein 5 isoform gamma

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
8378084 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8440710 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
8378084 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CREB5 Protein Structure

bZIP_1

bZIP_1: bZIP transcription factor (377 - 434)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
Protein Preferred Names Protein Names

cyclic AMP-responsive element-binding protein 5

  • cAMP response element-binding protein CRE-BPa

Related Diseases

Diseases Alias
Trichuriasis

  • Whipworm Infection

  • Whipworm Disease

  • Trichocephaliasis

  • Infection By Trichuris Trichura

  • Trichuriasis Infection

  • Trichuris Trichiura Infection

  • Infection By Trichuris Trichiura

  • Trichocephalosis

  • Infection By Trichocephalus Trichiura

  • Infection By Trichuris

  • Infection By Trichuris Trichiuria

  • Trichuriosis

  • Whipworm

  • Infection Due To Trichuris Trichiura

  • Trichocephalus Infestation

  • Trichuris Infestation

  • Whipworm Infestation
Achalasia

  • Cardiospasm

  • Achalasia Of Cardia

  • Esophageal Achalasia

  • Hypertensive Lower Esophageal Sphincter

  • Idiopathic Achalasia

  • Achalasia Cardia

  • Idiopathic Achalasia Of Esophagus

  • Primary Achalasia

  • Achalasia Of Esophagus

  • Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter

  • Aperistalsis Of The Oesophagus

  • Achalasia Of Oesophagus

  • Oesophageal Achalasia

  • Achalasia Nos

  • Cardia Spasm

  • Cardia Achalasia

  • Oesophageal Cardiospasm

  • Oesophagus Achalasia

  • Reflex Cardiospasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03154 CREB5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21540 Creb5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28058 Creb5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CREB5 VGNC VGNC:39600
Felis catus CREB5 VGNC VGNC:61170
Mus musculus CREB5 MGD MGI:2443973
Rattus norvegicus CREB5 RGD RGD:1566107
Macaca mulatta CREB5 VGNC VGNC:81295
Bos taurus CREB5 VGNC VGNC:106699
Others CREB5 NCBI