CCT7 - chaperonin containing TCP1 subunit 7 Gene

Also Known as CCTH; CCTETA; NIP7-1; TCP1ETA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10574

About CCT7

Cytogenetic location: 2p13.2 Genomic coordinates (GRCh38): 2:73,234,308-73,253,005 (from NCBI)

This gene has 16 transcripts (splice variants), 231 orthologues and 13 paralogues. Ubiquitous expression in testis (RPKM 102.9), adrenal (RPKM 73.8) and 25 other tissues.

Summary

This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]

CCT7 Products (4)

mRNA	Protein	Name
NM_001009570.3	NP_001009570.1	T-complex protein 1 subunit eta isoform b
NM_001166284.2	NP_001159756.1	T-complex protein 1 subunit eta isoform c
NM_001166285.2	NP_001159757.1	T-complex protein 1 subunit eta isoform d
NM_006429.4	NP_006420.1	T-complex protein 1 subunit eta isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14532270	GOA
enables protein folding chaperone	IDA IDA: Inferred from direct assay	25467444	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chaperone mediated protein folding independent of cofactor	IMP IMP: Inferred from mutant phenotype	25467444	GOA
involved in chaperone-mediated protein folding	IDA IDA: Inferred from direct assay	22133715	GOA
acts upstream of positive regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	25467444	GOA
involved in protein folding	IDA IDA: Inferred from direct assay	30955883	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	25467444	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of chaperonin-containing T-complex	IDA IDA: Inferred from direct assay	23011926	GOA
part of chaperonin-containing T-complex	IPI IPI: Inferred from physical interaction	22133715	GOA
located in microtubule	IDA IDA: Inferred from direct assay	21525035	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCT7 Protein Structure

Cpn60_TCP1

0
100
200
300
400
500
543 a.a.

Protein Preferred Names	Protein Names
T-complex protein 1 subunit eta	CCT-eta

CCT7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCT7	Q99832	CCT2	Homo sapiens	P78371	Anti Tag CoIP	28514442
Intra	CCT7	Q99832	CCT2	Homo sapiens	P78371	Anti Tag CoIP	35271311
Intra	CCT7	Q99832	NHLH1	Homo sapiens	Q02575	Y2H Prey Pooling	32296183
Intra	CCT7	Q99832	NHLH1	Homo sapiens	Q02575	Y2H Array	32296183
Intra	CCT7	Q99832	WBP2	Homo sapiens	Q969T9	Y2H Array	32296183
Intra	CCT7	Q99832	WBP2	Homo sapiens	Q969T9	Y2H Prey Pooling	32296183
Intra	CCT7	Q99832	ZNRD2	Homo sapiens	O60232	Anti Tag CoIP	35271311
Intra	CCT7	Q99832	ZNRD2	Homo sapiens	O60232	Y2H Array	31515488
Intra	CCT7	Q99832	ZNRD2	Homo sapiens	O60232	Validated Y2H	25416956
Intra	CCT7	Q99832	ZNRD2	Homo sapiens	O60232	Y2H Array	25416956
Intra	CCT7	Q99832	ZNRD2	Homo sapiens	O60232	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Babesiosis	Babesiasis Infection By Babesia Piroplasmosis Human Babesiosis Babesia Parasite Infection Piroplasma Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02184	CCT7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CCT7	VGNC	VGNC:27000
Mus musculus	CCT7	MGD	MGI:107184
Rattus norvegicus	CCT7	RGD	RGD:1306422
Macaca mulatta	CCT7	VGNC	VGNC:103798
Felis catus	CCT7	VGNC	VGNC:60581
Others	CCT7	NCBI