NANOS2 - nanos C2HC-type zinc finger 2 Gene

Also Known as NOS2; ZC2HC12B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 339345

About NANOS2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,913,214-45,914,778 (from NCBI)

This gene has 1 transcript (splice variant), 231 orthologues and 2 paralogues.

Summary

Predicted to enable mRNA binding activity. Involved in negative regulation of translation and positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NANOS2 Products (1)

mRNA Protein Name
NM_001029861.3 NP_001025032.1 nanos homolog 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme activator activity IDA
IDA: Inferred from direct assay
24736845 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24736845 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA destabilization IDA
IDA: Inferred from direct assay
24736845 GOA
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
24736845 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19168545 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22899867 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19168545 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NANOS2 Protein Structure

zf-nanos

zf-nanos: Nanos RNA binding domain (63 - 116)

  • 0
  • 100
  • 138 a.a.
Protein Preferred Names Protein Names

nanos homolog 2

  • NOS-2

NANOS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NANOS2 P60321 S100A10 Homo sapiens P60903
Y2H Prey Pooling
32296183
Intra
NANOS2 P60321 S100A10 Homo sapiens P60903
Validated Y2H
32296183
Intra
NANOS2 P60321 S100A10 Homo sapiens P60903
Y2H Array
32296183
Intra
NANOS2 P60321 CCNDBP1 Homo sapiens O95273
Y2H Array
31515488
Intra
NANOS2 P60321 CCNDBP1 Homo sapiens O95273
Validated Y2H
25416956
Intra
NANOS2 P60321 MAGEA12 Homo sapiens P43365
Y2H Array
32296183
Intra
NANOS2 P60321 MAGEA12 Homo sapiens P43365
Y2H Prey Pooling
25416956
Intra
NANOS2 P60321 MAGEA12 Homo sapiens P43365
Y2H Prey Pooling
32296183
Intra
NANOS2 P60321 MAGEA12 Homo sapiens P43365
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fanconi Anemia, Complementation Group L

  • Fanconi Anemia Complementation Group L

  • FANCL
Spermatogenic Failure, X-Linked, 1

  • Sertoli Cell-Only Syndrome

  • Germinal Cell Aplasia

  • Del Castillo Syndrome

  • SPGFX1

  • X-Linked Spermatogenic Failure 1

  • Congenital Absence Of Germinal Epithelium Of Testes
Spermatocytoma

  • Spermatocytic Seminoma
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Spermatogenic Failure, Y-Linked, 2

  • SPGFY2

  • Spermatogenic Failure, Nonobstructive, Y-Linked

  • Y-Linked Spermatogenic Failure 2

  • Azoospermia, Nonobstructive, Y-Linked

  • Oligozoospermia, Nonobstructive, Y-Linked

  • Oligospermia, Nonobstructive, Y-Linked

  • Spermatogenic Arrest, Y-Linked

  • Nonobstructive Y-Linked Spermatogenic Failure

  • Spermatogenic Failure Y-Linked 2

  • Azoospermia Non-Obstructive Y-Linked

  • Non-Obstructive Azoospermia And Infertility

  • Oligospermia Non-Obstructive Y-Linked

  • Oligozoospermia Non-Obstructive Y-Linked

  • Spermatogenic Arrest Y-Linked

  • Spermatogenic Failure Nonobstructive Y-Linked
Cryptorchidism, Unilateral Or Bilateral

  • Cryptorchidism

  • Undescended Testicle

  • Undescended Testis

  • Cryptorchism

  • Undescended Testicles

  • CRYPTO

  • Impaired Testicular Descent

  • Cryptosporidiosis

  • Retained Testis

  • Unilateral Cryptorchidism

  • Unilateral Undescended Testis

  • Nondescent Unilateral Testicle

  • Unilateral Cryptorchism

  • Ectopic Testis, Unilateral

  • Bilateral Cryptorchidism

  • Bilateral Cryptorchism

  • Bilateral Nondescent Testicle

  • Bilateral Undescended Testes

  • Bilateral Ectopic Testes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09022 NANOS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NANOS2 VGNC VGNC:31876
Canis familiaris NANOS2 VGNC VGNC:43614
Macaca mulatta NANOS2 VGNC VGNC:75009
Felis catus NANOS2 VGNC VGNC:63719
Rattus norvegicus NANOS2 RGD RGD:1562436
Mus musculus NANOS2 MGD MGI:2676627
Others NANOS2 NCBI