CARF - calcium responsive transcription factor Gene

Also Known as ALS2CR8; NYD-SP24

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79800

About CARF

Cytogenetic location: 2q33.2 Genomic coordinates (GRCh38): 2:202,912,275-202,988,263 (from NCBI)

This gene has 20 transcripts (splice variants) and 172 orthologues. Broad expression in testis (RPKM 5.9), thyroid (RPKM 3.4) and 24 other tissues.

Summary

Enables DNA binding activity and DNA-binding transcription factor activity. Involved in cellular response to potassium ion and positive regulation of transcription from RNA polymerase II promoter in response to calcium ion. Predicted to be located in granular component. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CARF Products (12)

mRNA Protein Name
NM_001104586.4 NP_001098056.1 calcium-responsive transcription factor isoform 1
NM_001282910.3 NP_001269839.1 calcium-responsive transcription factor isoform 2
NM_001282911.3 NP_001269840.1 calcium-responsive transcription factor isoform 2
NM_001282912.3 NP_001269841.1 calcium-responsive transcription factor isoform 3
NM_001322427.3 NP_001309356.1 calcium-responsive transcription factor isoform 1
NM_001322428.3 NP_001309357.1 calcium-responsive transcription factor isoform 1
NM_001322429.3 NP_001309358.1 calcium-responsive transcription factor isoform 4
NM_001352676.2 NP_001339605.1 calcium-responsive transcription factor isoform 6
NM_001352677.2 NP_001339606.1 calcium-responsive transcription factor isoform 7
NM_001352678.2 NP_001339607.1 calcium-responsive transcription factor isoform 8
NM_001352679.2 NP_001339608.1 calcium-responsive transcription factor isoform 8
NM_024744.17 NP_079020.13 calcium-responsive transcription factor isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11832226 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11832226 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
11832226 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CARF Protein Structure

ALS2CR8

ALS2CR8: Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 (251 - 483)

  • 0
  • 200
  • 400
  • 600
  • 725 a.a.
Protein Preferred Names Protein Names

calcium-responsive transcription factor

  • amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8

CARF Antibodies

Cat. No. Product Name Application Reactivity
HY-P82330 ALS2CR8 Antibody (YA2075) WB Human
HY-P82330A ALS2CR8 Antibody (YA2075)(PBS only) WB Human

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis 2, Juvenile

  • ALS2

  • Als, Juvenile

  • Alsj

  • Amyotrophic Lateral Sclerosis Type 2

  • Amyotrophic Lateral Sclerosis 2

  • Amyotrophic Lateral Sclerosis Type 2, Juvenile

  • Amyotrophic Lateral Sclerosis Juvenile

  • Amyotrophic Lateral Sclerosis Juvenile 2

  • Sclerosis, Lateral, Amyotrophic, Type Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01924 CARF Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CARF VGNC VGNC:38719
Mus musculus CARF MGD MGI:2182269
Macaca mulatta CARF VGNC VGNC:70518
Felis catus CARF VGNC VGNC:107493
Rattus norvegicus CARF RGD RGD:1306822
Bos taurus CARF VGNC VGNC:26765
Others CARF NCBI