IACS-15414
Based on 1 Customer Validation
IACS-15414 is a potent and orally bioavailable SHP2 inhibitor with an IC50 value of 122 nM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.39%
- No. CAS: 2411321-29-2
- Fòrmula: C20H24Cl2N4O2
- Peso molecular:423.34
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Kinase Inhibitor Library
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Metabolism/Protease Compound Library
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Protein Tyrosine Kinase Compound Library
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Anti-Cancer Compound Library
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Posttranslational Modification Library
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Actividad biológica
Chemical Information
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No. CAS 2411321-29-2
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Appearance Solid
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Peso molecular 423.34
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Fòrmula C20H24Cl2N4O2
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Color White to light yellow
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SMILES
ClC1=CC=CC(N2C(C)=NC(N3CCC4([C@H](N)[C@H](C)OC4)CC3)=CC2=O)=C1Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (236.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (5.91 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (5.91 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.3622 mL | 11.8108 mL | 23.6217 mL | 59.0542 mL |
| 5 mM | 0.4724 mL | 2.3622 mL | 4.7243 mL | 11.8108 mL | |
| 10 mM | 0.2362 mL | 1.1811 mL | 2.3622 mL | 5.9054 mL | |
| 15 mM | 0.1575 mL | 0.7874 mL | 1.5748 mL | 3.9369 mL | |
| 20 mM | 0.1181 mL | 0.5905 mL | 1.1811 mL | 2.9527 mL | |
| 25 mM | 0.0945 mL | 0.4724 mL | 0.9449 mL | 2.3622 mL | |
| 30 mM | 0.0787 mL | 0.3937 mL | 0.7874 mL | 1.9685 mL | |
| 40 mM | 0.0591 mL | 0.2953 mL | 0.5905 mL | 1.4764 mL | |
| 50 mM | 0.0472 mL | 0.2362 mL | 0.4724 mL | 1.1811 mL | |
| 60 mM | 0.0394 mL | 0.1968 mL | 0.3937 mL | 0.9842 mL | |
| 80 mM | 0.0295 mL | 0.1476 mL | 0.2953 mL | 0.7382 mL | |
| 100 mM | 0.0236 mL | 0.1181 mL | 0.2362 mL | 0.5905 mL |
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