WWTR1 - WW domain containing transcription regulator 1 Gene

Also Known as TAZ

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25937

About WWTR1

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:149,517,235-149,724,788 (from NCBI)

This gene has 12 transcripts (splice variants), 160 orthologues, 1 paralogue and is associated with 64 phenotypes. Ubiquitous expression in gall bladder (RPKM 24.8), endometrium (RPKM 22.7) and 24 other tissues.

Summary

Enables transcription coactivator activity. Involved in several processes, including hippo signaling; positive regulation of cell differentiation; and regulation of signal transduction. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

WWTR1 Products (4)

mRNA	Protein	Name
NM_001168278.3	NP_001161750.1	WW domain-containing transcription regulator protein 1
NM_001168280.3	NP_001161752.1	WW domain-containing transcription regulator protein 1
NM_001348362.2	NP_001335291.1	WW domain-containing transcription regulator protein 1
NM_015472.6	NP_056287.1	WW domain-containing transcription regulator protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16099986	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	19010321	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	23911299	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	19010321	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in SMAD protein signal transduction	IDA IDA: Inferred from direct assay	18568018	GOA
involved in hippo signaling	IDA IDA: Inferred from direct assay	18227151	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20412773	GOA
involved in negative regulation of fat cell differentiation	IGI IGI: Inferred from genetic interaction	29496737	GOA
involved in negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	20412773	GOA
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	20412773	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	18227151	GOA
involved in positive regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	18227151	GOA
involved in positive regulation of osteoblast differentiation	IGI IGI: Inferred from genetic interaction	29496737	GOA
involved in stem cell division	IDA IDA: Inferred from direct assay	18568018	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20412773	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	19010321	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18568018	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WWTR1 Protein Structure

0
100
200
300
400 a.a.

Protein Preferred Names	Protein Names
WW domain-containing transcription regulator protein 1	transcriptional co-activator with PDZ-binding motif

WWTR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WWTR1	Q9GZV5	TCP11L1	Homo sapiens	Q9NUJ3	Validated Y2H	32296183
Intra	WWTR1	Q9GZV5	BTRC	Homo sapiens	Q9Y297	Anti Tag CoIP	33961781
Intra	WWTR1	Q9GZV5	CCAR1	Homo sapiens	Q8IX12	Anti Bait CoIP	20594350
Intra	WWTR1	Q9GZV5	YWHAE	Homo sapiens	P62258	Y2H Pooling	20936779
Intra	WWTR1	Q9GZV5	YWHAE	Homo sapiens	P62258	CoIP	16099986
Intra	WWTR1	Q9GZV5	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	33961781
Intra	WWTR1	Q9GZV5	SCRIB	Homo sapiens	Q14160	Anti Bait CoIP	22078877
Intra	WWTR1	Q9GZV5	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	33961781
Intra	WWTR1	Q9GZV5	LATS1	Homo sapiens	O95835	Anti Bait CoIP	22078877
Intra	WWTR1	Q9GZV5	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	23245942
Intra	WWTR1	Q9GZV5	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	22234184
Intra	WWTR1	Q9GZV5	DVL1	Homo sapiens	O14640	Lumier	20412773
Intra	WWTR1	Q9GZV5	WBP2	Homo sapiens	Q969T9	Anti Tag CoIP	20972459
Intra	WWTR1	Q9GZV5	WBP2	Homo sapiens	Q969T9	Pull Down	20972459
Intra	WWTR1	Q9GZV5	DVL2	Homo sapiens	O14641	Lumier	20412773
Intra	WWTR1	Q9GZV5	DVL2	Homo sapiens	O14641	Anti Bait CoIP	20412773
Intra	WWTR1	Q9GZV5	TEAD3	Homo sapiens	Q99594	Anti Tag CoIP	28514442
Intra	WWTR1	Q9GZV5	TEAD3	Homo sapiens	Q99594	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Epithelioid Hemangioendothelioma	Hemangioendothelioma Epithelioid Epithelioid Hemangioendothelioma, Malignant
Malignant Epithelioid Hemangioendothelioma	Epithelioid Hemangioendothelioma, Malignant
Histiocytoid Hemangioma	Angiolymphoid Hyperplasia With Eosinophilia Epithelioid Haemangioma Epithelioid Hemangioma
Hemangioendothelioma
Malignant Hemangioma
Sveinsson Chorioretinal Atrophy	SCRA Atrophia Areata Helicoid Peripapillary Chorioretinal Degeneration Hpcd Aa Peripapillary Chorioretinal Degeneration, Icelandic Type Helicoidal Peripapillary Chorioretinal Degeneration Atrophy, Chorioretinal, Sveinsson
Eccrine Acrospiroma	Acrospiroma Poroma Eccrine Hidradenoma Eccrine Hidradenoma Of Skin Hidradenoma Adenoma, Sweat Gland Benign Neoplasm Of Sweat Gland Eccrine Poroma
Eccrine Sweat Gland Neoplasm	Eccrine Skin Neoplasm Eccrine Tumor Eccrine Neoplasm Malignant Eccrine Neoplasm
Choroid Plexus Meningioma	Choroid Meningioma Meningioma Of The Choroid Plexus
Eccrine Porocarcinoma	Porocarcinoma Eccrine Porocarcinoma Of Skin Malignant Eccrine Poroma
Eccrine Sweat Gland Cancer	Malignant Eccrine Skin Neoplasm Malignant Eccrine Tumor
Intestinal Obstruction	Inspissated Milk Syndrome Milk Curd Syndrome
Childhood Angiosarcoma	Paediatric Angiosarcoma Paediatric Hemangiosarcoma Pediatric Angiosarcoma Pediatric Hemangiosarcoma
Vascular Cancer	Blood Vessel Tumors Malignant Vascular Neoplasm Renal Vein Leiomyosarcoma Vascular Neoplasms Blood Vessel Neoplasm Blood Vessel Tumor Blood Vessel Tumour Disorder Haemangiomatous Tumour Leiomyosarcoma Of The Renal Vein Malignant Great Vessel Tumor Malignant Tumor Of Pulmonary Artery Malignant Tumor Of Pulmonary Vein Malignant Vascular Tumor Neoplasm Of Great Vessel Pulmonary Artery Malignant Neoplasm Pulmonary Vein Malignant Neoplasm Vascular Tissue Neoplasm Vascular Tumors Blood Vessel Cancer Neoplasms, Vascular Tissue Malignant Neoplasm Of Great Vessels
Neurofibromatosis, Type Ii	Neurofibromatosis 2 Neurofibromatosis, Type 2 NF2 Neurofibromatosis Type Ii Bilateral Acoustic Neurofibromatosis Banf Acn Central Neurofibromatosis Neurofibromatosis, Central Type Acoustic Schwannomas, Bilateral Acoustic Neurinoma, Bilateral Bilateral Acoustic Neurinoma Bilateral Acoustic Schwannomas Familial Acoustic Neuromas
Cerebral Cavernous Malformations	Cerebral Cavernous Malformation Cavernous Malformations Of Cns And Retina Cerebral Cavernous Malformation 1 Cavernous Angiomatous Malformations Cerebral Capillary Malformations CCM Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations Familial Cavernous Angioma Cavernous Angioma Familial Cerebral Cavernous Malformation Cerebral Cavernous Malformations 1 Cavernous Angioma, Familial Cam Cerebral Cavernous Malformations-1 Cavernoma Central Nervous System Cavernous Hemangioma Cerebral Cavernous Hemangioma Familial Cavernous Hemangioma Familial Cavernous Malformation Familial Cerebral Cavernous Angioma Intracerebral Cavernous Hemangioma CCM1 Cavernous Hemangioma Of The Brain Cerebral Cavernoma Cerebral Cavernous Malformations, Type 1 Hemangioma, Cavernous, Central Nervous System Hemangioma, Cavernous Angioma, Cavernous
Rhabdomyosarcoma
Sclerosing Hepatic Carcinoma	Sclerosing Hepatocellular Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16236	Wwtr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15862	WWTR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16450	Wwtr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	WWTR1	RGD	RGD:1559609
Mus musculus	WWTR1	MGD	MGI:1917649
Canis familiaris	WWTR1	VGNC	VGNC:52910
Macaca mulatta	WWTR1	VGNC	VGNC:79415
Felis catus	WWTR1	VGNC	VGNC:102868
Bos taurus	WWTR1	VGNC	VGNC:36980
Others	WWTR1	NCBI