RASSF3 - Ras association domain family member 3 Gene

Also Known as RASSF5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 283349

About RASSF3

Cytogenetic location: 12q14.2 Genomic coordinates (GRCh38): 12:64,506,964-64,697,564 (from NCBI)

This gene has 6 transcripts (splice variants), 221 orthologues and 5 paralogues. Ubiquitous expression in spleen (RPKM 26.7), appendix (RPKM 26.2) and 25 other tissues.

Summary

The Ras oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the Ras superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of Ras effectors, including RASSF3, share a Ras association (RA) domain.[supplied by OMIM, Jul 2003]

RASSF3 Products (1)

mRNA	Protein	Name
NM_178169.4	NP_835463.1	ras association domain-containing protein 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	20920251	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20920251	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASSF3 Protein Structure

RA

0
100
200
238 a.a.

Protein Preferred Names	Protein Names
ras association domain-containing protein 3	Ras association (RalGDS/AF-6) domain family 3

RASSF3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RASSF3	Q86WH2	TRIM59	Homo sapiens	Q8IWR1	Validated Y2H	32296183
Intra	RASSF3	Q86WH2	FAM110A	Homo sapiens	Q9BQ89	Validated Y2H	32296183
Intra	RASSF3	Q86WH2	ITPRIP	Homo sapiens	Q8IWB1	Validated Y2H	32296183
Intra	RASSF3	Q86WH2	LITAF	Homo sapiens	Q99732	Validated Y2H	32296183
Intra	RASSF3	Q86WH2	STK4	Homo sapiens	Q13043	Y2H	20920251
Intra	RASSF3	Q86WH2	STK3	Homo sapiens	Q13188	Anti Tag CoIP	24366813
Intra	RASSF3	Q86WH2	STK3	Homo sapiens	Q13188	Y2H	20920251
Intra	RASSF3	Q86WH2	STK4	Homo sapiens	Q13043	Anti Tag CoIP	24366813
Intra	RASSF3	Q86WH2	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	32296183
Intra	RASSF3	Q86WH2	KDM1A	Homo sapiens	O60341	Y2H Prey Pooling	32296183
Intra	RASSF3	Q86WH2	KDM1A	Homo sapiens	O60341	Y2H Array	32296183
Intra	RASSF3	Q86WH2	CBX8	Homo sapiens	Q9HC52	Validated Y2H	32296183
Intra	RASSF3	Q86WH2	TENT5D	Homo sapiens	Q8NEK8	Validated Y2H	32296183
Intra	RASSF3	Q86WH2	RPRD1B	Homo sapiens	Q9NQG5	Validated Y2H	32296183
Intra	RASSF3	Q86WH2	DAXX	Homo sapiens	Q9UER7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Growth Hormone Secreting Pituitary Adenoma	Somatotroph Adenoma Growth Hormone-Secreting Pituitary Adenoma Growth Hormone Producing Adenoma Of The Pituitary Growth Hormone Secreting Adenoma Of Pituitary
Glaucoma, Normal Tension	Low Tension Glaucoma Glaucoma, Normal Tension, Susceptibility To Normal Tension Glaucoma Ntg Glaucoma, Normal Pressure NPG Glaucoma, Normal Pressure, Susceptibility To Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11703	RASSF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11705	RASSF5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RASSF3	VGNC	VGNC:33759
Canis familiaris	RASSF3	VGNC	VGNC:54537
Rattus norvegicus	RASSF3	RGD	RGD:1311450
Mus musculus	RASSF3	MGD	MGI:2179722
Others	RASSF3	NCBI