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Cat. No.: HY-117852

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CGP-59326

(Synonyms: TRX-13)

CGP-59326 (TRX-13) is a highly potent and selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (IC₅₀=0.027 μM). CGP-59326 blocks the EGFR signaling pathwa, demonstrating highly selective inhibition of EGFR-dependent tumor cells. CGP-59326 is promising for research of cancers.

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CAS No.: 173458-56-5
Formule: C₁₄H₁₃ClN₄
Masse moléculaire:272.73

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CGP-59326 Chemical Structure

CAS No.: 173458-56-5

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
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- Cellular Effect
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform EGFR :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	ED₅₀	1.5 mg/kg Compound: 13	In vivo efficacy following oral administration in nude mouse tumor model, xenograft A431 cells expressing EGF-R In vivo efficacy following oral administration in nude mouse tumor model, xenograft A431 cells expressing EGF-R	[PMID: 8691423]
A-431	IC₅₀	0.3 μM Compound: 13	Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-R Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-R	[PMID: 8691423]
Balb/MK	IC₅₀	1.4 μM Compound: 13	Inhibition of proliferation of EGF-dependent BALB/MK cells Inhibition of proliferation of EGF-dependent BALB/MK cells	[PMID: 8691423]
NIH3T3	IC₅₀	>10 μM Compound: 13	Inhibition of PDGF-stimulated tyrosine phosphorylation in BALB/c 3T3 cells Inhibition of PDGF-stimulated tyrosine phosphorylation in BALB/c 3T3 cells	[PMID: 8691423]
NIH3T3	IC₅₀	>100 μM Compound: 13	Inhibition of PDGF-induced c-fos mRNA expression in BALB/c 3T3 cells Inhibition of PDGF-induced c-fos mRNA expression in BALB/c 3T3 cells	[PMID: 8691423]
NIH3T3	IC₅₀	>100 μM Compound: 13	Inhibition of PMA/PKC-mediated c-fos mRNA expression in BALB/c 3T3 cells Inhibition of PMA/PKC-mediated c-fos mRNA expression in BALB/c 3T3 cells	[PMID: 8691423]
NIH3T3	IC₅₀	2 μM Compound: 13	Inhibition of EGF-induced c-fos mRNA expression in BALB/c 3T3 cells Inhibition of EGF-induced c-fos mRNA expression in BALB/c 3T3 cells	[PMID: 8691423]

Chemical Information

CAS No. 173458-56-5
Masse moléculaire 272.73
Formule C₁₄H₁₃ClN₄
SMILES

ClC1=CC=CC(NC2=NC=NC3=C2C(C)=C(C)N3)=C1
Synonyms

TRX-13
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Traxler P, et al. Strategies toward the design of novel and selective protein tyrosine kinase inhibitors. Pharmacol Ther. 1999 May-Jun;82(2-3):195-206. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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CGP-59326

Voir tous les produits spécifiques à Isoform EGFR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CGP-59326 Related Classifications

HY-117852 Related Classifications