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Cat. No.: HY-N9680

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Coenzyme Q8

(Synonyms: Ubiquinone 8)

Coenzyme Q8 (Ubiquinone 8) is an isoprenoid quinone that mediates electron transfer within the aerobic respiratory chain and reduces oxidative stress. Coenzyme Q8 maintains bacterial respiratory function and enhances host resistance to bacterial infection. Coenzyme Q8 stimulates macrophage phagocytosis and increases antibody-producing cells. Coenzyme Q8 can be used in infectious disease research.

For research use only. We do not sell to patients.

CAS No.: 2394-68-5
Formula: C₄₉H₇₄O₄
Molecular Weight:727.11

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Coenzyme Q8 Chemical Structure

CAS No.: 2394-68-5

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

Coenzyme Q8 (2 h) enhances phagocytosis of sheep erythrocytes by peritoneal macrophages from normal animals^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Coenzyme Q8 (25 mg/kg; i.v.) provides complete protection against otherwise lethal infections with gram-negative and gram-positive bacteria in female NMRI mice, enhances bacterial clearance from blood, stimulates macrophage phagocytosis and increases antibody-producing cells in spleens^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2394-68-5
Appearance Solid
Molecular Weight 727.11
Formula C₄₉H₇₄O₄
Color White to off-white
SMILES

C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC(C(C(OC)=C1OC)=O)=C(C)C1=O
Synonyms

Ubiquinone 8
Structure Classification
- Quinones
- Benzene Quinones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Laura Tempelhagen, et al. Cultivation at high osmotic pressure confers ubiquinone 8-independent protection of respiration on Escherichia coli. J Biol Chem. 2020 Jan 24;295(4):981-993. [Content Brief]

[2]. Block LH, et al. Nonspecific resistance to bacterial infections. Enhancement by ubiquinone-8. J Exp Med. 1978 Nov 1;148(5):1228-40. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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