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GANT 61

(Synonyms: NSC 136476)
67 Cited Publications
Revisión del cliente

Based on 67 publication(s) in Google Scholar

GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.

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  • Pureza: 99.80%
  • No. CAS: 500579-04-4
  • Fòrmula: C27H35N5
  • Peso molecular:429.60
  • Almacenamiento:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • GANT 61 Chemical Structure
    GANT 61 Chemical Structure
  • Experimental Validation Results for GANT 61
  • Experimental Validation Results for GANT 61
  • Experimental Validation Results for GANT 61
  • Experimental Validation Results for GANT 61
  • Experimental Validation Results for GANT 61
  • Experimental Validation Results for GANT 61
  • Experimental Validation Results for GANT 61
  • Experimental Validation Results for GANT 61
  • Experimental Validation Results for GANT 61
  • Experimental Validation Results for GANT 61
  • Experimental Validation Results for GANT 61
No. CAS: 500579-04-4
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Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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  • GANT 61 Chemical Structure
    GANT 61 Chemical Structure
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  • 1/16

    GANT 61 purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2018 Apr 28:420:195-207. [Abstract]

    Customer Validation
     Shh-Light 2 cells are transfected with Gli1 or Gli2 plasmids and the expression of proteins are analyzed by Western blot. Positive control JQ1, CBC and CBD inhibit Gli1 and Gli2 overexpression induced Gli luciferase activity, GDC-0499 and GANT61 have no effects.

  • 1/16

    GANT 61 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Jun 26:9:674. [Abstract]

    Customer Validation
     Cyclopamine and GANT61 decrease the level of Gli1 as evidenced by western blot.

  • 1/16

    GANT 61 purchased from MedChemExpress. Usage Cited in: Cancer Med. 2018 Nov;7(11):5704-5715. [Abstract]

    Customer Validation
     The Hh signaling pathway is involved in DHA induced inhibition of cell proliferation. A and B, CCK8 assay of SKOV3 and SKOV3-IP cells is conducted following treatment with purmorphamine, DHA or a combination of DHA and purmorphamine for 48 h. C and D, SKOV3 and SKOV3‐IP cells are treated with GANT61, DHA, or a combination of DHA and GATN61 for 48 h, while controls are treated with DMSO. CCK8 assay is used to analyze cell viability of SKOV3 and SKOV3-IP cells.

  • 1/16

    GANT 61 purchased from MedChemExpress. Usage Cited in: Chinese Pharmacological Bulletin. 2018, 34(9): 1235-1242.

    Customer Validation
     Expression of Gli1/2 (A) and DNA damage proteins (B) at OGD 6 h detected by Western blot.

  • 1/16

    GANT 61 purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2017 Jan 28:385:128-136. [Abstract]

    Customer Validation
     GANT61 or SHH siRNA treatment alone moderately increases LC3-II, and LC3-II increased in cells co-treated with R51211 and GANT61 or SHH siRNA.

  • 1/16

    GANT 61 purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2017 Dec 13;9(49):42544-42555. [Abstract]

    Customer Validation
     ATG101 cross-talk with the hedgehog pathway modulates hypoxia-induced HPAEC cell proliferation and apoptosis. Effects of ssATG101-TNP on the hedgehog pathway. HPAECs are pretreated with ssATG101-TNP and GANT61; then, they are under hypoxia for 24 h.

  • 1/16

    GANT 61 purchased from MedChemExpress. Usage Cited in: Life Sci. 2017 Dec 15:191:82-89. [Abstract]

    Customer Validation
     ORS cells are exposed to 3% oxygen for 48 h in presence or absence of Shh pathway inhibitor cyclopamine (5 μM) or GANT61 (10 μM). Immunofluorescence assay using anti-PCNA antibody is performed to detect the proliferative ORS cells (red). Cell nuclei are counterstained with DAPI (blue).

  • 1/16

    GANT 61 purchased from MedChemExpress. Usage Cited in: Cancer Sci. 2017 May;108(5):918-930. [Abstract]

    Customer Validation
     Effects of E2 and GANT61 on the protein expression levels of GLI1 and GLI2 in MCF-7 cells. The expression levels are measured with a western blotting as described in the Materials and Methods.

  • 1/16

    GANT 61 purchased from MedChemExpress. Usage Cited in: Breast Cancer. 2017 Sep;24(5):683-693. [Abstract]

    Customer Validation
     Effects of GANT61 (0-20μM) on the expression levels of survivin in MDA-MB-231 cells. The cells are treated with the indicated concentrations of GANT61 for two days. The expression levels are tested using western blotting. The deduced molecular weight of surviving is approximately 16 kDa.

  • 1/16

    GANT 61 purchased from MedChemExpress. Usage Cited in: University of Colorado. 2016 Aug.

    Customer Validation
     Western blot analyses of whole cell lysates (WCLs) collected from MCF7-Ctrl cells cultured in MCF7-Ctrl and Six1 CM for 48 hrs treated with GANT61 or vehicle.

  • 1/16

    GANT 61 purchased from MedChemExpress. Usage Cited in: Oncotarget. 2015 Nov 3;6(34):36700-12. [Abstract]

    Customer Validation
     BE2-M17 NB cells are incubated with GANT-61 (0–40 μM) for 3 days. The cell viability is monitored using an MTS assay. The expression levels of N-myc and INSM1 in the cells treated with 20 μM of GANT-61 is determined by Western blot analysis. Actin is used as a loading control.

  • GANT 61