Cx3cl1 - chemokine (C-X3-C motif) ligand 1 Gene

Also Known as FK; CX3C; Cxc3; Scyd1; ABCD-3; D8Bwg0439e

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20312

Summary

Enables CX3C Chemokine Receptor binding activity and chemokine activity. Acts upstream of or within several processes, including angiogenesis involved in wound healing; leukocyte chemotaxis; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in several cellular components, including cell surface; neuron projection; and neuronal cell body. Is expressed in several structures, including brain; genitourinary system; gut; nose; and respiratory system. Human ortholog(s) of this gene implicated in Cor pulmonale and common cold. Orthologous to human CX3CL1 (C-X3-C motif chemokine ligand 1). [provided by Alliance of Genome Resources, Apr 2022]

Cx3cl1 Products (1)

mRNA	Protein	Name
NM_009142.3	NP_033168.2	fractalkine precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables CX3C chemokine receptor binding	IDA IDA: Inferred from direct assay	18971423	MGI

Biological Process GO Annotation	Evidence	Referencias	Source
acts upstream of or within angiogenesis involved in wound healing	IMP IMP: Inferred from mutant phenotype	18097059	MGI
acts upstream of or within cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18971423	MGI
acts upstream of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	18322241	MGI
acts upstream of or within lymphocyte chemotaxis	IDA IDA: Inferred from direct assay	9177350	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	18322241	MGI
acts upstream of or within neutrophil chemotaxis	IDA IDA: Inferred from direct assay	9177350	MGI
acts upstream of or within positive regulation of transforming growth factor beta1 production	IMP IMP: Inferred from mutant phenotype	18097059	MGI
acts upstream of or within wound healing	IMP IMP: Inferred from mutant phenotype	18097059	MGI

Cellular Component GO Annotation	Evidence	Referencias	Source
located in cell body	IDA IDA: Inferred from direct assay	12815711	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	12815711	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	12815711	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	28612258	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
fractalkine	C-X3-C motif chemokine 1 CX3C membrane-anchored chemokine neurotactin small inducible cytokine subfamily D, 1 small-inducible cytokine D1

Recombinant Cx3cl1 Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P71888	Fractalkine/CX3CL1 Protein, Mouse	O35188 (Q25-G100)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72686	Fractalkine/CX3CL1 Protein, Mouse (HEK293, His)	O35188 (Q25-R337)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78113	Fractalkine/CX3CL1 Protein, Mouse (Biotinylated, HEK293, His-Avi)	O35188 (Q25-T336)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-175746	AZD0233	Antagonist	98.66%	Unkown
HY-RS16603	Cx3cl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03378	CX3CL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181016	CX3CR1-IN-2	Inhibitor	/	Unkown
HY-RS23037	Cx3cl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-P99404	Quetmolimab	Inhibitor	99.9%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cx3cl1	NCBI	NCBI:6376
Canis familiaris	Cx3cl1	NCBI	NCBI:487265
Macaca fascicularis	Cx3cl1	NCBI	NCBI:102117496
Rattus norvegicus	Cx3cl1	NCBI	NCBI:89808