country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cx3cl1 - C-X3-C motif chemokine ligand 1 Gene

Also Known as Cx3c; Scyd1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 89808

Summary

Enables chemokine activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of gene expression; and regulation of signal transduction. Located in several cellular components, including neuron projection; neuronal cell body; and perinuclear region of cytoplasm. Used to study acute pancreatitis; ischemia; and status epilepticus. Biomarker of several diseases, including borna disease; brain disease (multiple); liver disease (multiple); lung disease (multiple); and pulmonary hypertension. Human ortholog(s) of this gene implicated in Cor pulmonale and common cold. Orthologous to human CX3CL1 (C-X3-C motif chemokine ligand 1). [provided by Alliance of Genome Resources, Apr 2022]

Cx3cl1 Products (1)

mRNA	Protein	Name
NM_134455.2	NP_604450.2	fractalkine precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables chemokine activity	IDA IDA: Inferred from direct assay	9724801	RGD

Biological Process GO Annotation	Evidence	Références	Source
involved in G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	12729461	RGD
involved in autocrine signaling	IGI IGI: Inferred from genetic interaction	12729461	RGD
involved in cell-cell adhesion	IDA IDA: Inferred from direct assay	12729461	RGD
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	12729461	RGD
involved in chemokine-mediated signaling pathway	IGI IGI: Inferred from genetic interaction	12729461	RGD
involved in chemotaxis	IDA IDA: Inferred from direct assay	9724801	RGD
involved in chemotaxis	IGI IGI: Inferred from genetic interaction	16019082	RGD
involved in inhibitory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	19748551	RGD
involved in microglial cell activation	IDA IDA: Inferred from direct assay	11870871	RGD
involved in negative regulation of glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	16019082	RGD
involved in negative regulation of interleukin-1 alpha production	IDA IDA: Inferred from direct assay	19627440	RGD
involved in negative regulation of vasoconstriction	IDA IDA: Inferred from direct assay	19201996	RGD
involved in neuron cellular homeostasis	IDA IDA: Inferred from direct assay	16019082	RGD
involved in positive regulation of canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	12729461	RGD
involved in positive regulation of cell adhesion	IDA IDA: Inferred from direct assay	17114429	RGD
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	17114429	RGD
involved in positive regulation of macrophage chemotaxis	IMP IMP: Inferred from mutant phenotype	19282612	RGD
involved in positive regulation of neuroblast proliferation	IDA IDA: Inferred from direct assay	20018408	RGD
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	23825416	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	12729461	RGD
involved in positive regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	12729461	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12729461	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	18630689	RGD
involved in response to ischemia	IGI IGI: Inferred from genetic interaction	12059974	RGD

Cellular Component GO Annotation	Evidence	Références	Source
located in cell projection	IDA IDA: Inferred from direct assay	11870871	RGD
located in extracellular region	IDA IDA: Inferred from direct assay	16019082	RGD
located in membrane	IDA IDA: Inferred from direct assay	16019082	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	15341587	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12059974	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11870871	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
fractalkine	C-X3-C motif chemokine 1 CX3C membrane-anchored chemokine chemokine (C-X3-C motif) ligand 1 neurotactin small inducible cytokine subfamily D, 1 small-inducible cytokine D1

Recombinant Cx3cl1 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P79193	Fractalkine/CX3CL1 Protein, Rat	O55145 (L22-G100)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-175746	AZD0233	Antagonist	98.66%	Unkown
HY-RS16603	Cx3cl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03378	CX3CL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181016	CX3CR1-IN-2	Inhibitor	/	Unkown
HY-RS23037	Cx3cl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P99404	Quetmolimab	Inhibitor	99.9%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cx3cl1	NCBI	NCBI:6376
Canis familiaris	Cx3cl1	NCBI	NCBI:487265
Macaca fascicularis	Cx3cl1	NCBI	NCBI:102117496
Mus musculus	Cx3cl1	NCBI	NCBI:20312