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PRKCH - protein kinase C eta Gene

Also Known as PKCL; PKC-L; PRKCL; uORF2; nPKC-eta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5583

About PRKCH

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:61,187,468-61,550,976 (from NCBI)

This gene has 27 transcripts (splice variants), 241 orthologues, 9 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 18.8), spleen (RPKM 14.7) and 24 other tissues.

Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the Transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015]

PRKCH Products (8)

mRNA	Protein	Name
NM_006255.5	NP_006246.2	protein kinase C eta type
XM_024449661.2	XP_024305429.1	protein kinase C eta type isoform X4
XM_024449662.2	XP_024305430.1	protein kinase C eta type isoform X4
XM_011536957.2	XP_011535259.1	protein kinase C eta type isoform X6
XM_011536955.2	XP_011535257.1	protein kinase C eta type isoform X3
XM_047431586.1	XP_047287542.1	protein kinase C eta type isoform X5
XM_011536954.4	XP_011535256.1	protein kinase C eta type isoform X2
XM_047431585.1	XP_047287541.1	protein kinase C eta type isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	15632189	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19114660	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	34593629	GOA
enables protein serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	34593629	GOA
enables protein serine/threonine kinase inhibitor activity	IDA IDA: Inferred from direct assay	34593629	GOA
enables translation regulator activity	IDA IDA: Inferred from direct assay	19797084	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in cellular response to amino acid starvation	IDA IDA: Inferred from direct assay	19797084	GOA
involved in negative regulation of glial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	11772428	GOA
involved in negative regulation of protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	34593629	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	19797084	GOA
involved in negative regulation of translation	IMP IMP: Inferred from mutant phenotype	34593629	GOA
involved in positive regulation of B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18780722	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	21820409	GOA
involved in positive regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	10806212	GOA
involved in positive regulation of translation in response to stress	IDA IDA: Inferred from direct assay	19797084	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	34593629	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22304920	GOA
involved in regulation of bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	19114660	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15632189	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15632189	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKCH Protein Structure

C1_1

Pkinase

Pkinase_C

0
200
400
600
683 a.a.

Protein Preferred Names	Protein Names
protein kinase C eta type	Protein uPEP2

PRKCH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Cross	PRKCH	P24723	OCLN	Canis familiaris	Q28269	Anti Bait CoIP	19114660
Cross	PRKCH	P24723	OCLN	Canis familiaris	Q28269	Anti Tag CoIP	19114660

Cross: Cross-species interaction Intra: Intraspecies interaction

PRKCH Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P80869	PKC eta Antibody (YA126)	WB, IP	Human, Mouse, Rat
HY-P80869A	PKC eta Antibody (YA126)(PBS only)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Amphetamine Abuse

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Pureza	Rare Diseases
HY-RS11131	PRKCH Human Pre-designed siRNA Set A	/	Unkown
HY-RS11132	Prkch Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS11133	Prkch Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRKCH	MGD	MGI:97600
Canis familiaris	PRKCH	VGNC	VGNC:44981
Rattus norvegicus	PRKCH	RGD	RGD:621888
Bos taurus	PRKCH	VGNC	VGNC:33332
Macaca mulatta	PRKCH	VGNC	VGNC:84424
Felis catus	PRKCH	VGNC	VGNC:104609
Others	PRKCH	NCBI