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MLX - MAX dimerization protein MLX Gene

Also Known as TF4; MAD7; MXD7; TCFL4; bHLHd13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6945

About MLX

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,567,100-42,573,203 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in duodenum (RPKM 29.5), small intestine (RPKM 29.2) and 25 other tissues.

Summary

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

MLX Products (3)

mRNA	Protein	Name
NM_170607.3	NP_733752.1	max-like protein X isoform gamma
NM_198204.2	NP_937847.1	max-like protein X isoform beta
NM_198205.2	NP_937848.1	max-like protein X isoform alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11230181	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	EXP EXP: Inferred from Experiment	14742444	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10918583	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	10918583	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10918583	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11230181	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11230181	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	11230181	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11230181	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10918583	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11073985	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10918583	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10918583	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLX Protein Structure

HLH

0
100
200
298 a.a.

Protein Preferred Names	Protein Names
max-like protein X	BigMax protein

MLX Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	MLX	Q9UH92	ZBTB32	Homo sapiens	A0A0C4DGF1	Y2H Array	25416956
Intra	MLX	Q9UH92	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	MLX	Q9UH92	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	MLX	Q9UH92	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	MLX	Q9UH92	GABARAPL2	Homo sapiens	P60520	Y2H Pooling	16189514
Intra	MLX	Q9UH92	GABARAPL2	Homo sapiens	P60520	Validated Y2H	25416956
Intra	MLX	Q9UH92	GABARAPL2	Homo sapiens	P60520	Y2H Array	25416956
Cross	MLX	Q9UH92	HBZ	Human T-lymphotropic virus	Q2Q067	MAPPIT	22458338
Cross	MLX	Q9UH92	HBZ	Human T-lymphotropic virus	Q2Q067	Y2H Pooling	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ovarian Dysgenesis 3	ODG3 Dysgenesis, Ovarian, Type 3
Takayasu Arteritis	Aortic Arch Syndrome Pulseless Disease Takayasu'S Arteritis Idiopathic Aortitis Young Female Arteritis Aortic Arch Arteritis Aortic Arches Defect Aortic Arch Defects Takayasu Disease Aortic Arch Syndromes Takayasu'S Disease Ta Obliterative Aortitis Aortic Arch Giant-Cell Arteritis Subclavian-Carotid Obstruction Syndrome Idiopathic Medial Aortopathy And Arteriopathy Takayasu Syndrome Obliterative Brachiocephalic Arteritis Syndrome Raeder-Harbitz Syndrome Chronic Subclavian-Carotid Obstruction Syndrome Giant-Cell Aortitis Takayasu Aortitis Nonspecific Aortoarteritis Sclerosing Aortitis And Arteritis Martorell 2 Syndrome Young Female Aortic Arch Arteritis Syndrome
Dental Fluorosis	Mottled Teeth Intrinsic Enamel Discolouration Of Fluorosis Mottling Of Enamel Fluorosis, Dental Dental Fluorosis, Acquired
Benign Essential Hypertension
Williams-Beuren Syndrome	Williams Syndrome WBS Wms Deletion 7q11.23 Monosomy 7q11.23 Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb Fanconi Schlesinger Syndrome Beuren Syndrome Elfin Facies Syndrome Elfin Facies With Hypercalcemia Hypercalcemia-Supravalvar Aortic Stenosis Ws
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome	Mrxs13 Lindsay-Burn Syndrome Ppm-X Ppm-X Syndrome Mental Retardation With Psychosis, Pyramidal Signs, And Macroorchidism Mental Retardation, X-Linked, Syndromic 13 X-Linked Mental Retardation 79 X-Linked Mental Retardation With Spasticity Intellectual Deficit, X-Linked - Psychosis - Macroorchidism Intellectual Disability Psychosis Macroorchidism Intellectual Disability With Psychosis, Pyramidal Signs, And Macroorchidism Intellectual Disability, X-Linked, Syndromic 13 Ppmx X-Linked Mental Retardation, Syndromic 13
Olfactory Groove Meningioma	Meningioma Of The Olfactory Groove

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS08503	MLX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08505	MLXIPL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21156	Mlxipl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MLX	VGNC	VGNC:31508
Mus musculus	MLX	MGD	MGI:108398
Rattus norvegicus	MLX	RGD	RGD:1308590
Canis familiaris	MLX	VGNC	VGNC:43267
Felis catus	MLX	VGNC	VGNC:63528
Macaca mulatta	MLX	VGNC	VGNC:74726
Others	MLX	NCBI