MLX - MAX dimerization protein MLX Gene

Homo sapiens

Also known as TF4; MAD7; MXD7; TCFL4; bHLHd13

Gene ID: 6945 | Gene type: protein coding

About MLX

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,567,100-42,573,203 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in duodenum (RPKM 29.5), small intestine (RPKM 29.2) and 25 other tissues.

Summary

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

MLX Products(3)

mRNA	Protein	Name
NM_170607.3	NP_733752.1	max-like protein X isoform gamma
NM_198204.2	NP_937847.1	max-like protein X isoform beta
NM_198205.2	NP_937848.1	max-like protein X isoform alpha

MLX Protein Structure

HLH

0
100
200
298 a.a.

Protein Preferred Names

Protein Names

max-like protein X

BigMax protein

Related Diseases

Diseases

Alias

Ovarian Dysgenesis 3

ODG3	Dysgenesis, Ovarian, Type 3

Takayasu Arteritis

Aortic Arch Syndrome	Pulseless Disease
Takayasu'S Arteritis	Idiopathic Aortitis
Young Female Arteritis	Aortic Arch Arteritis
Aortic Arches Defect	Aortic Arch Defects
Takayasu Disease	Aortic Arch Syndromes
Takayasu'S Disease	Ta
Obliterative Aortitis	Aortic Arch Giant-Cell Arteritis
Subclavian-Carotid Obstruction Syndrome	Idiopathic Medial Aortopathy And Arteriopathy
Takayasu Syndrome	Obliterative Brachiocephalic Arteritis Syndrome
Raeder-Harbitz Syndrome	Chronic Subclavian-Carotid Obstruction Syndrome
Giant-Cell Aortitis	Takayasu Aortitis
Nonspecific Aortoarteritis	Sclerosing Aortitis And Arteritis
Martorell 2 Syndrome	Young Female Aortic Arch Arteritis Syndrome

Dental Fluorosis

Mottled Teeth	Intrinsic Enamel Discolouration Of Fluorosis
Mottling Of Enamel	Fluorosis, Dental
Dental Fluorosis, Acquired

Benign Essential Hypertension

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome

Mrxs13	Lindsay-Burn Syndrome
Ppm-X	Ppm-X Syndrome
Mental Retardation With Psychosis, Pyramidal Signs, And Macroorchidism	Mental Retardation, X-Linked, Syndromic 13
X-Linked Mental Retardation 79	X-Linked Mental Retardation With Spasticity
Intellectual Deficit, X-Linked - Psychosis - Macroorchidism	Intellectual Disability Psychosis Macroorchidism
Intellectual Disability With Psychosis, Pyramidal Signs, And Macroorchidism	Intellectual Disability, X-Linked, Syndromic 13
Ppmx	X-Linked Mental Retardation, Syndromic 13

Olfactory Groove Meningioma

Meningioma Of The Olfactory Groove

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08503	MLX Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MLX	VGNC	VGNC:31508
Mus musculus	MLX	MGD	MGI:108398
Rattus norvegicus	MLX	RGD	RGD:1308590
Canis familiaris	MLX	VGNC	VGNC:43267
Felis catus	MLX	VGNC	VGNC:63528
Macaca mulatta	MLX	VGNC	VGNC:74726