AKT1S1 - AKT1 substrate 1 Gene

Also Known as Lobe; PRAS40

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84335

About AKT1S1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,869,033-49,878,356 (from NCBI)

This gene has 9 transcripts (splice variants) and 174 orthologues. Ubiquitous expression in fat (RPKM 12.1), kidney (RPKM 8.8) and 25 other tissues.

Summary

AKT1S1 is a proline-rich substrate of Akt (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008]

AKT1S1 Products (5)

mRNA Protein Name
NM_001098632.2 NP_001092102.1 proline-rich AKT1 substrate 1 isoform b
NM_001098633.4 NP_001092103.1 proline-rich AKT1 substrate 1 isoform b
NM_001278159.2 NP_001265088.1 proline-rich AKT1 substrate 1 isoform b
NM_001278160.2 NP_001265089.1 proline-rich AKT1 substrate 1 isoform b
NM_032375.5 NP_115751.3 proline-rich AKT1 substrate 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
12524439 GOA
enables protein kinase inhibitor activity IDA
IDA: Inferred from direct assay
18372248 GOA
enables protein serine/threonine kinase inhibitor activity IDA
IDA: Inferred from direct assay
17386266 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in negative regulation of TOR signaling IDA
IDA: Inferred from direct assay
17386266 GOA
involved in negative regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
17386266 GOA
involved in negative regulation of cell size IDA
IDA: Inferred from direct assay
17386266 GOA
involved in negative regulation of protein kinase activity IDA
IDA: Inferred from direct assay
17386266 GOA
Cellular Component GO Annotation Evidence Referencias Source
part of TORC1 complex IDA
IDA: Inferred from direct assay
17386266 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proline-rich AKT1 substrate 1

  • 40 kDa proline-rich AKT substrate

AKT1S1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
AKT1S1 Q96B36 YWHAH Homo sapiens Q04917
Anti Tag CoIP
35271311
Intra
AKT1S1 Q96B36 YWHAH Homo sapiens Q04917
Pull Down
12524439
Intra
AKT1S1 Q96B36 YWHAZ Homo sapiens P63104
Pull Down
15161933
Cross: Cross-species interaction Intra: Intraspecies interaction

AKT1S1 Antibodies

Referencia número Nombre del producto Aplicación Reactivity
HY-P83434 PRAS40 Antibody (YA3179) WB, IP Human, Rat
HY-P83434A PRAS40 Antibody (YA3179)(PBS only) WB, IP Human, Rat
HY-P84720 PRAS40 Antibody (YA4417) IHC-P, ICC/IF, ELISA Human
HY-P84720A PRAS40 Antibody (YA4417)(PBS only) IHC-P, ICC/IF, ELISA Human
HY-P86153 Phospho-PRAS40(Thr246) Antibody (YA5845) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat
HY-P86433 PRAS40 Antibody (YA6125) WB, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Breast Intraductal Papillomatosis

  • Breast Papillomatosis

  • Intraductal Papillomatosis Of The Breast
Subependymal Glioma

  • Mixed Subependymoma-Ependymoma

  • Subependymal Astrocytoma

  • Who Grade I Ependymal Tumor

  • Glioma, Subependymal
Cowden Syndrome 1

  • Bannayan-Riley-Ruvalcaba Syndrome

  • Pten Hamartoma Tumor Syndrome

  • Lhermitte-Duclos Disease

  • Bannayan-Zonana Syndrome

  • Phts

  • Riley-Smith Syndrome

  • Bzs

  • Ruvalcaba-Myhre-Smith Syndrome

  • Multiple Hamartoma Syndrome

  • Rmss

  • Brrs

  • Dysplastic Gangliocytoma Of The Cerebellum

  • CWS1

  • Cs

  • Cd

  • Mham

  • Pten Hamartoma Tumor Syndrome With Granular Cell Tumor

  • Macrocephaly Multiple Lipomas And Hemangiomata

  • Bannayan-Ruvalcaba-Riley Syndrome

  • Myhre-Riley-Smith Syndrome

  • LDD

  • Cerebelloparenchymal Disorder Vi

  • Hamartoma Syndrome, Multiple

  • Bbrs

  • Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata

  • Macrocephaly, Multiple Lipomas, And Hemangiomata

  • Macrocephaly Pseudopapilledema And Multiple Hemangiomas

  • Ruvalcaba -Myhre-Smith Syndrome

  • Ruvalcaba-Myhre Syndrome

  • Cowden Disease

  • Macrocephaly Pseudopapilledema And Multiple Hemangiomata

  • Cerebellar Granule Cell Hypertrophy And Megalencephaly

  • Cpd6

  • Pten Hamartoma Tumor Syndromes

  • Cowden Syndrome, Type 1
Neurodegeneration With Brain Iron Accumulation

  • Nbia

  • Neurodegeneration With Brain Iron Accumulation Disorders

  • Neurodegeneration, With Brain Iron Accumulation
Proteus Syndrome

  • Proteus Syndrome, Somatic

  • Partial Gigantism-Nevi-Hemihypertrophy-Macrocephaly Syndrome

  • Gigantism, Partial, Of Hands And Feet, Nevi, Hemihypertrophy, And Macrocephaly

  • Wiedemann'S Syndrome

  • Hemihypertrophy And Macrocephaly

  • Partial Gigantism Of Hands And Feet, Nevi, Hemihypertrophy, Macrocephaly

  • Ps

  • PROTEUSS

  • Partial Gigantism Of Hands And Feet Nevi Hemihypertrophy And Macrocephaly
Cowden Syndrome

  • Cowden Disease

  • Multiple Hamartoma Syndrome

  • Cowden'S Disease

  • Lhermitte-Duclos Disease

  • Cd

  • Cs

  • Mham

  • Dysplastic Gangliocytoma Of Cerebellum

  • Cowden'S Syndrome

  • Hamartoma Syndrome, Multiple
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS00545 AKT1S1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris AKT1S1 VGNC VGNC:37771
Rattus norvegicus AKT1S1 RGD RGD:1312049
Mus musculus AKT1S1 MGD MGI:1914855
Macaca mulatta AKT1S1 VGNC VGNC:108461
Bos taurus AKT1S1 VGNC VGNC:25798
Others AKT1S1 NCBI