IVHD-valtrate
IVHD-valtrate, an active Valeriana jatamansi derivative, is against human ovarian cancer cells in vitro and in vivo. IVHD-valtrate induces cancer cells apoptosis and arrests the ovarian cancer cells in the G2/M phase. IVHD-valtrate has the potential to be a novel chemotherapeutic agent for the human ovarian cancer research.
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- No. CAS: 28325-56-6
- Fòrmula: C27H40O11
- Peso molecular:540.60
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
IC50: apoptosis[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
7.4 μM
Compound: 18
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Cytotoxicity against human A549 cells after 24 hrs by MTT assay
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
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[PMID: 19245261] |
| Bel-7402 | IC50 |
4 μM
Compound: 18
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Cytotoxicity against human Bel7402 cells after 24 hrs by MTT assay
Cytotoxicity against human Bel7402 cells after 24 hrs by MTT assay
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[PMID: 19245261] |
| HCT-8 | IC50 |
2.5 μM
Compound: 18
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Cytotoxicity against human HCT8 cells after 24 hrs by MTT assay
Cytotoxicity against human HCT8 cells after 24 hrs by MTT assay
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[PMID: 19245261] |
| PC-3M | IC50 |
1.9 μM
Compound: 18
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Cytotoxicity against human PC3M cells after 24 hrs by MTT assay
Cytotoxicity against human PC3M cells after 24 hrs by MTT assay
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[PMID: 19245261] |
IVHD-valtrate inhibits the growth and proliferation of the A2780 and OVCAR-3 ovarian cancer cell lines in a concentration-dependent manner[1].IVHD-valtrate results in a relatively low cytotoxicity to immortalized non-tumorigenic human ovarian surface epithelial cells (IOSE-144)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 28325-56-6
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Peso molecular 540.60
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Fòrmula C27H40O11
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SMILES
CC(O[C@@H](C1)[C@]2(CO2)[C@]([C@@H]3OC(CC(C)C)=O)([H])[C@]1(C(COC(C(C(C)C)OC(CC(C)C)=O)=O)=CO3)O)=O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IVHD-valtrate Related Classifications
HY-N3446 Related Classifications
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