XY25028
XY25028 is an orally active LRH-1 inhibitor with an IC50 of 0.30 μM. XY25028 inhibits the proliferation of androgen receptor (AR)-positive prostate cancer cells and suppresses the expression of AR target genes KLK2 and KLK3. XY25028 can be used in the research of castration-resistant prostate cancer.
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- Fòrmula: C32H38N2O3
- Peso molecular:498.66
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Actividad biológica
XY25028 (96 h) inhibits the viability of 22Rv1, C4-2B and LNCaP human prostate cancer cell lines, with IC50 values of 14.46 μM, 17.41 μM and 20.88 μM, respectively[1].
XY25028 (10-40 μM; 48 h) inhibits the mRNA expression of KLK2 and KLK3 in 22Rv1 human prostate cancer cells in a dose-dependent manner[1].
XY25028 (2.5-40 μM; 48 h) inhibits c-Myc protein expression in human prostate cancer cell line 22Rv1 after 48 h of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:22Rv1 human prostate cancer cells
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Concentration:10 μM, 20 μM, 40 μM
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Incubation Time:48 h
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Result:Significantly reduced KLK3 mRNA levels.
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Cell Line:22Rv1 human prostate cancer cells
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Concentration:2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM
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Incubation Time:48 h
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Result:Significantly reduced c-Myc protein expression at 20 μM and 40 μM compared to vehicle control.
Showed no significant changes in c-Myc protein expression at 2.5 μM, 5 μM, or 10 μM compared to vehicle control.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c-Nude (male, 5 weeks old)[1]
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Dosage:50 mg/kg
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Administration:p.o.; once daily; 16 consecutive days
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Result:Achieved a tumor growth inhibition (TGI) rate of 40.7%.
Showed no significant body weight changes (a marker of systemic toxicity) throughout the 16-day study period.
Chemical Information
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Peso molecular 498.66
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Fòrmula C32H38N2O3
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SMILES
NC1=CC=C(N(CC2=CC=CC=C2)C=C3C4=CC=C(OCCCCCCC(OC(C)(C)C)=O)C=C4)C3=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
XY25028 Related Classifications
HY-181971 Related Classifications
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