Sco2 - SCO2 cytochrome c oxidase assembly protein Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 100126824

Summary

Predicted to enable protein-disulfide reductase activity. Acts upstream of or within several processes, including copper ion homeostasis; respiratory chain complex IV assembly; and response to activity. Located in mitochondrion. Is expressed in several structures, including alimentary system; aorta; blastocyst; gonad; and hemolymphoid system gland. Used to study cytochrome-c oxidase deficiency disease. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease; fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency 1; hypertrophic cardiomyopathy; and myopia. Orthologous to human SCO2 (synthesis of cytochrome C oxidase 2). [provided by Alliance of Genome Resources, Apr 2022]

Sco2 Products (1)

mRNA Protein Name
NM_001111288.2 NP_001104758.1 protein SCO2 homolog, mitochondrial

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within copper ion homeostasis IMP
IMP: Inferred from mutant phenotype
19837698 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
19837698 MGI
acts upstream of or within muscle system process IMP
IMP: Inferred from mutant phenotype
19837698 MGI
acts upstream of or within respiratory chain complex IV assembly IMP
IMP: Inferred from mutant phenotype
19837698 MGI
acts upstream of or within respiratory electron transport chain IMP
IMP: Inferred from mutant phenotype
19837698 MGI
acts upstream of or within response to activity IMP
IMP: Inferred from mutant phenotype
19837698 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
19837698 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein SCO2 homolog, mitochondrial

  • SCO cytochrome oxidase deficient homolog 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12557 SCO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20816 Sco2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27330 Sco2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sco2 NCBI NCBI:9997