Mir34a - microRNA 34a Gene

Also Known as rno-mir-34a

Species: Rattus norvegicus

Gene Type: ncRNA
Gene ID: 100314015

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
29373037 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-R00714 hsa-miR-34a-5p mimic 98.24% Unkown
HY-R03076 mmu-miR-34a-3p mimic 97.74% Unkown
HY-RI00714 hsa-miR-34a-5p inhibitor 96.23% Unkown
HY-RI00713A hsa-miR-34a-3p antagomir 95.25% Unkown
HY-RI00714A hsa-miR-34a-5p antagomir 99.65% Unkown
HY-RI03076 mmu-miR-34a-3p inhibitor 91.68% Unkown
HY-R00713 hsa-miR-34a-3p mimic 96.40% Unkown
HY-R00713A hsa-miR-34a-3p agomir 99.19% Unkown
HY-R00714A hsa-miR-34a-5p agomir 99.90% Unkown
HY-119833 Rubone Modulator 99.1% Unkown
HY-R03076A mmu-miR-34a-3p agomir 95.30% Unkown
HY-RI04609 rno-miR-34a-5p inhibitor Inhibitor / Unkown
HY-R04374 rno-miR-34a-3p mimic / Unkown
HY-R04374A rno-miR-34a-3p agomir / Unkown
HY-RI00713 hsa-miR-34a-3p inhibitor / Unkown
HY-RI03076A mmu-miR-34a-3p antagomir / Unkown
HY-RI04374 rno-miR-34a-3p inhibitor / Unkown
HY-RI04374A rno-miR-34a-3p antagomir / Unkown
HY-R04614 rno-miR-34a-5p mimic / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir34a NCBI NCBI:407040