MIR34A - microRNA 34a Gene
Also Known as mir-34; MIRN34A; mir-34a; miRNA34A
Species: Homo sapiens
About MIR34A
This gene has 1 transcript (splice variant), 99 orthologues and 2 paralogues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. This miRNA is a member of the highly conserved miR-34 family. This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with Cancer progression in numerous cell types. [provided by RefSeq, Sep 2015]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
24637697 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
23426265 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular exosome |
IDA
IDA: Inferred from direct assay
|
31926946 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Retinoblastoma |
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| Neuroblastoma |
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| Glioma |
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| Leukemia, Chronic Lymphocytic |
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| Glioblastoma |
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| Melanoma |
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| Hepatocellular Carcinoma |
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| Medulloblastoma |
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| Esophageal Cancer |
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| Alzheimer Disease, Familial, 1 |
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| Myelodysplastic Syndrome |
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| Gastric Cancer |
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| Pancreatic Cancer |
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| Prostate Cancer |
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| Colorectal Cancer |
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| Lung Cancer |
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| Breast Cancer |
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| Non-Alcoholic Fatty Liver Disease |
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| Facioscapulohumeral Muscular Dystrophy 1 |
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| Leiomyoma, Uterine |
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| Inclusion Body Myositis |
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| Muscular Dystrophy, Duchenne Type |
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| Polymyositis |
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| Dermatomyositis |
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| Diabetes Mellitus |
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| Nemaline Myopathy |
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| Oral Squamous Cell Carcinoma |
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| Autonomic Nervous System Neoplasm |
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| Peripheral Nervous System Neoplasm |
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| Non-Alcoholic Steatohepatitis |
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| Cervix Disease |
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| Fatty Liver Disease |
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| Lipid Storage Disease |
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| Central Nervous System Cancer |
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| Lymphatic System Cancer |
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| Large Intestine Cancer |
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| Lymphatic System Disease |
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| Male Reproductive Organ Cancer |
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| Bone Inflammation Disease |
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| Colonic Disease |
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| Endocrine Gland Cancer |
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| Reproductive System Disease |
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| Male Reproductive System Disease |
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| Respiratory System Cancer |
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| Uterine Anomalies |
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| Bladder Disease |
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| Female Reproductive System Disease |
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| Placenta Accreta |
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| Immune System Disease |
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| Endocrine System Disease |
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| Ocular Cancer |
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| Acquired Metabolic Disease |
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| Thoracic Cancer |
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| Mycosis Fungoides |
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| Pancreas Disease |
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| Respiratory System Disease |
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| Intestinal Disease |
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| Retinal Cancer |
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| Gastrointestinal System Cancer |
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| Overnutrition |
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| Arteries, Anomalies Of |
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| Bone Marrow Cancer |
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| Non-Syndromic X-Linked Intellectual Disability 21 |
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| Gastrointestinal System Disease |
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| Connective Tissue Cancer |
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| Sensory System Disease |
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| Inherited Metabolic Disorder |
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| Malignant Exocrine Pancreas Neoplasm |
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| Liver Disease |
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| Autoimmune Disease Of Musculoskeletal System |
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| Urinary System Disease |
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| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
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| Spinal Disease |
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| Central Nervous System Benign Neoplasm |
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| Ovarian Disease |
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| Malignant Astrocytoma |
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| Prostate Disease |
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| Glucose Metabolism Disease |
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| Carbohydrate Metabolic Disorder |
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| Ovary Epithelial Cancer |
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| Aortic Valve Disease 2 |
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| Central Nervous System Disease |
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| Cervical Cancer |
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| Stomach Disease |
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| Peripheral Nervous System Disease |
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| Integumentary System Disease |
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| Breast Disease |
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| Myocardial Infarction |
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| Head And Neck Cancer |
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| Hematologic Cancer |
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| Aortic Disease |
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| Bone Cancer |
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| Heart Valve Disease |
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| Esophageal Disease |
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| Endometrial Adenocarcinoma |
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| Oligospermia |
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| Lysosomal Storage Disease |
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| Lymphoma, Non-Hodgkin, Familial |
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| Connective Tissue Disease |
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| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma |
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| Peripheral T-Cell Lymphoma |
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| Pancreatic Ductal Adenocarcinoma |
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| Bone Disease |
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| Mesothelioma, Malignant |
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| Nervous System Disease |
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| Disease By Infectious Agent |
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| Pilocytic Astrocytoma |
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| Meningioma, Familial |
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| Brain Cancer |
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| Renal Cell Carcinoma, Nonpapillary |
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| Eye Disease |
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| Cardiovascular System Disease |
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| Leukemia, Acute Myeloid |
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| Ovarian Cancer |
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| Hypertension, Essential |
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| Body Mass Index Quantitative Trait Locus 11 |
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| Skin Disease |
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| Immune Deficiency Disease |
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| Lipoprotein Quantitative Trait Locus |
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| Hemochromatosis, Type 1 |
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| Dilated Cardiomyopathy |
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| Type 2 Diabetes Mellitus |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MIR34A | RGD | RGD:2325584 |
| Mus musculus | MIR34A | MGD | MGI:3619363 |