Mir222 - microRNA 222 Gene

Rattus norvegicus

Also known as rno-mir-222

Gene ID: 100314059 | Gene type: ncRNA

About Mir222

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis involved in wound healing	IMP IMP: Inferred from mutant phenotype	27545451	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	32194220	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	28854428	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	19438724	RGD
involved in cellular response to polyamine macromolecule	IEP IEP: Inferred from expression pattern	21737690	RGD
involved in lactation	IEP IEP: Inferred from expression pattern	30698333	RGD
involved in mesenchymal cell differentiation involved in bone development	IMP IMP: Inferred from mutant phenotype	31691506	RGD
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	25863248	RGD
involved in negative regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	33792838	RGD
involved in negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	21737690	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	31691506	RGD
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	25484256	RGD
involved in negative regulation of ossification	IMP IMP: Inferred from mutant phenotype	31691506	RGD
involved in negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	32194220	RGD
involved in positive regulation of Schwann cell migration	IMP IMP: Inferred from mutant phenotype	22393241	RGD
involved in positive regulation of Schwann cell proliferation	IMP IMP: Inferred from mutant phenotype	22393241	RGD
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	33792838	RGD
involved in positive regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	25863248	RGD
involved in positive regulation of cell size	IMP IMP: Inferred from mutant phenotype	25863248	RGD
involved in positive regulation of dendrite extension	IMP IMP: Inferred from mutant phenotype	23028614	RGD
involved in positive regulation of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	33792838	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	28854428	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	28859292	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	30698333	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	29037132	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	30698333	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RI04608	hsa-miR-222-3p inhibitor	Inhibitor	99.81%	Unkown
HY-R00466	hsa-miR-222-5p mimic		96.15%	Unkown
HY-R02846	mmu-miR-222-3p mimic		99.19%	Unkown
HY-R02847	mmu-miR-222-5p mimic		96.09%	Unkown
HY-R00466A	hsa-miR-222-5p agomir		/	Unkown
HY-R02846A	mmu-miR-222-3p agomir		/	Unkown
HY-R02847A	mmu-miR-222-5p agomir		/	Unkown
HY-R04312	rno-miR-222-5p mimic		/	Unkown
HY-R04312A	rno-miR-222-5p agomir		/	Unkown
HY-RI00466	hsa-miR-222-5p inhibitor		/	Unkown
HY-RI00466A	hsa-miR-222-5p antagomir		/	Unkown
HY-RI02846	mmu-miR-222-3p inhibitor		/	Unkown
HY-RI02846A	mmu-miR-222-3p antagomir		/	Unkown
HY-RI02847	mmu-miR-222-5p inhibitor		/	Unkown
HY-RI02847A	mmu-miR-222-5p antagomir		/	Unkown
HY-RI04312	rno-miR-222-5p inhibitor		/	Unkown
HY-RI04312A	rno-miR-222-5p antagomir		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mir222	NCBI	NCBI:407007

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