MIR222 - microRNA 222 Gene
Also Known as MIRN222; mir-222; miRNA222
Species: Homo sapiens
About MIR222
This gene has 1 transcript (splice variant), 128 orthologues and 1 paralogue.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
16330772 | GOA |
| enables mRNA base-pairing translational repressor activity |
IGI
IGI: Inferred from genetic interaction
|
21310411 | GOA |
| enables mRNA base-pairing translational repressor activity |
IMP
IMP: Inferred from mutant phenotype
|
20103675 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Tongue Squamous Cell Carcinoma |
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| Glioblastoma |
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| Thyroid Cancer, Nonmedullary, 1 |
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| Glioma |
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| Melanoma |
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| Prostate Cancer |
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| Hepatocellular Carcinoma |
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| Gastric Cancer |
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| Breast Cancer |
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| Lung Cancer |
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| Polymyositis |
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| Facioscapulohumeral Muscular Dystrophy 1 |
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| Dermatomyositis |
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| Inclusion Body Myositis |
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| Muscular Dystrophy, Duchenne Type |
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| Miyoshi Muscular Dystrophy 1 |
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| Lipoprotein Quantitative Trait Locus |
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| Leukemia, Acute Lymphoblastic |
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| Nemaline Myopathy |
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| Pancreatic Ductal Adenocarcinoma |
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| Pancreatic Cancer |
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| Bladder Cancer |
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| Leukemia, Acute Myeloid |
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| Trichorhinophalangeal Syndrome, Type I |
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| Ovarian Cancer |
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| Thyroid Gland Cancer |
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| Thyroid Gland Medullary Carcinoma |
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| Nonobstructive Coronary Artery Disease |
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| Thyroid Gland Disease |
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| Thyroid Gland Follicular Carcinoma |
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| Multinodular Goiter |
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| Ovary Epithelial Cancer |
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| Malignant Astrocytoma |
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| Central Nervous System Cancer |
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| Spinal Disease |
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| Ovarian Disease |
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| Connective Tissue Cancer |
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| Endocrine System Disease |
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| Endocrine Gland Cancer |
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| Sclerosing Cholangitis |
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| Follicular Adenoma |
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| Male Reproductive Organ Cancer |
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| Thyroid Gland Anaplastic Carcinoma |
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| Male Reproductive System Disease |
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| Lymphatic System Cancer |
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| Lymphatic System Disease |
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| Reproductive System Disease |
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| Multiple Endocrine Neoplasia, Type Iib |
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| Thoracic Cancer |
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| Arteries, Anomalies Of |
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| Female Reproductive System Disease |
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| Bone Cancer |
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| Renal Cell Carcinoma, Nonpapillary |
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| Immune System Disease |
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| Head And Neck Cancer |
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| Prostate Disease |
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| Pancreas Disease |
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| Glucose Metabolism Disease |
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| Carbohydrate Metabolic Disorder |
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| Gastrointestinal System Disease |
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| Gastrointestinal System Cancer |
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| Inherited Metabolic Disorder |
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| Severe Pre-Eclampsia |
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| Cholangitis, Primary Sclerosing |
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| Overnutrition |
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| Respiratory System Cancer |
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| Bladder Disease |
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| Respiratory System Disease |
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| Urinary System Disease |
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| Breast Disease |
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| Biliary Tract Cancer |
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| Brain Cancer |
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| Acquired Metabolic Disease |
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| Central Nervous System Disease |
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| Esophageal Disease |
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| Intestinal Disease |
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| Large Intestine Cancer |
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| Connective Tissue Disease |
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| Bone Inflammation Disease |
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| Gallbladder Disease |
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| Bone Disease |
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| Uterine Anomalies |
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| Colonic Disease |
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| Diabetes Mellitus |
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| Diffuse Large B-Cell Lymphoma |
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| Hypertension, Essential |
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| Hematologic Cancer |
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| Sensory System Disease |
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| Myelodysplastic Syndrome |
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| Colorectal Cancer |
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| Lymphoma, Non-Hodgkin, Familial |
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| Autoimmune Disease Of Musculoskeletal System |
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| Esophageal Cancer |
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| Nervous System Disease |
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| Cardiovascular System Disease |
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| Squamous Cell Carcinoma, Head And Neck |
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| Body Mass Index Quantitative Trait Locus 11 |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | MIR222 | MGD | MGI:3619118 |
| Rattus norvegicus | MIR222 | RGD | RGD:2325544 |