Msh6 - mutS homolog 6 Gene
Species: Rattus norvegicus
Summary
Predicted to enable several functions, including DNA binding activity; chromatin binding activity; and methylated histone binding activity. Predicted to contribute to several functions, including DNA binding activity; MutLalpha complex binding activity; and adenyl ribonucleotide binding activity. Involved in mismatch repair and spermatogenesis. Predicted to be located in several cellular components, including Golgi apparatus; chromatin; and nucleoplasm. Predicted to be part of MutSalpha complex. Used to study hereditary nonpolyposis colorectal Cancer type 5. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; hereditary nonpolyposis colorectal Cancer type 5; and mismatch repair Cancer syndrome. Orthologous to human MSH6 (mutS homolog 6). [provided by Alliance of Genome Resources, Apr 2022]
Msh6 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001398548.1 | NP_001385477.1 | mutS homolog 6 |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in mismatch repair |
IMP
IMP: Inferred from mutant phenotype
|
18417481 | RGD |
| involved in spermatogenesis |
IEP
IEP: Inferred from expression pattern
|
10644444 | RGD |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
DNA mismatch repair protein Msh6 mutS homolog 6 |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS08713 | MSH6 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS22241 | Msh6 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS28763 | Msh6 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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