Cdkl5 - cyclin-dependent kinase-like 5 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 100362725

Summary

Enables small GTPase binding activity. Involved in generation of neurons; positive regulation of GTPase activity; and positive regulation of dendritic spine development. Located in dendrite; perinuclear region of cytoplasm; and synapse. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Colocalizes with ruffle membrane. Human ortholog(s) of this gene implicated in Rett syndrome; developmental and epileptic encephalopathy 2; intellectual disability; and visual epilepsy. Orthologous to human CDKL5 (cyclin dependent kinase like 5). [provided by Alliance of Genome Resources, Apr 2022]

Cdkl5 Products (5)

mRNA Protein Name
XM_039100455.1 XP_038956383.1 cyclin-dependent kinase-like 5 isoform X2
XM_017602292.2 XP_017457781.1 cyclin-dependent kinase-like 5 isoform X4
XM_017602290.2 XP_017457779.1 cyclin-dependent kinase-like 5 isoform X1
XM_017602291.2 XP_017457780.1 cyclin-dependent kinase-like 5 isoform X3
XM_039100454.1 XP_038956382.1 cyclin-dependent kinase-like 5 isoform X1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23671101 RGD
enables small GTPase binding IPI
IPI: Inferred from physical interaction
20861382 RGD
Biological Process GO Annotation Evidence References Source
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
20861382 RGD
involved in positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
20861382 RGD
involved in positive regulation of axon extension IMP
IMP: Inferred from mutant phenotype
20861382 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
20861382 RGD
involved in positive regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
23671101 RGD
involved in regulation of dendrite development IMP
IMP: Inferred from mutant phenotype
20861382 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite cytoplasm IDA
IDA: Inferred from direct assay
20861382 RGD
located in dendritic growth cone IDA
IDA: Inferred from direct assay
20861382 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23671101 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
23671101 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
23671101 RGD
located in ruffle membrane IDA
IDA: Inferred from direct assay
20861382 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclin-dependent kinase-like 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-172198 GSK3-IN-10 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdkl5 NCBI NCBI:6792