Cdkl5 - cyclin-dependent kinase-like 5 Gene

Rattus norvegicus

Gene ID: 100362725 | Gene type: protein coding

About Cdkl5

Summary

Enables small GTPase binding activity. Involved in generation of neurons; positive regulation of GTPase activity; and positive regulation of dendritic spine development. Located in dendrite; perinuclear region of cytoplasm; and synapse. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Colocalizes with ruffle membrane. Human ortholog(s) of this gene implicated in Rett syndrome; developmental and epileptic encephalopathy 2; intellectual disability; and visual epilepsy. Orthologous to human CDKL5 (cyclin dependent kinase like 5). [provided by Alliance of Genome Resources, Apr 2022]

Cdkl5 Products(5)

mRNA	Protein	Name
XM_039100455.1	XP_038956383.1	cyclin-dependent kinase-like 5 isoform X2
XM_017602292.2	XP_017457781.1	cyclin-dependent kinase-like 5 isoform X4
XM_017602290.2	XP_017457779.1	cyclin-dependent kinase-like 5 isoform X1
XM_017602291.2	XP_017457780.1	cyclin-dependent kinase-like 5 isoform X3
XM_039100454.1	XP_038956382.1	cyclin-dependent kinase-like 5 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23671101	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	20861382	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	20861382	RGD
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	20861382	RGD
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	20861382	RGD
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	20861382	RGD
involved in positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	23671101	RGD
involved in regulation of dendrite development	IMP IMP: Inferred from mutant phenotype	20861382	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite cytoplasm	IDA IDA: Inferred from direct assay	20861382	RGD
located in dendritic growth cone	IDA IDA: Inferred from direct assay	20861382	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23671101	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	23671101	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	23671101	RGD
located in ruffle membrane	IDA IDA: Inferred from direct assay	20861382	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cyclin-dependent kinase-like 5

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-172198	GSK3-IN-10	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdkl5	NCBI	NCBI:6792

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