MAEA - macrophage erythroblast attacher, E3 ubiquitin ligase Gene

Homo sapiens

Also known as EMP; EMLP; GID9; PIG5; HLC-10; P44EMLP

Gene ID: 10296 | Gene type: protein coding

About MAEA

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:1,289,891-1,340,137 (from NCBI)

This gene has 20 transcripts (splice variants), 205 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 10.3), spleen (RPKM 10.0) and 25 other tissues.

Summary

This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing Apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

MAEA Products(6)

mRNA	Protein	Name
NM_001017405.3	NP_001017405.1	E3 ubiquitin-protein transferase MAEA isoform 1
NM_001297430.2	NP_001284359.1	E3 ubiquitin-protein transferase MAEA isoform 3
NM_001297431.2	NP_001284360.1	E3 ubiquitin-protein transferase MAEA isoform 4
NM_001297432.2	NP_001284361.1	E3 ubiquitin-protein transferase MAEA isoform 5
NM_001297433.2	NP_001284362.1	E3 ubiquitin-protein transferase MAEA isoform 6
NM_005882.5	NP_005873.2	E3 ubiquitin-protein transferase MAEA isoform 2

MAEA Protein Structure

CLTH

0
100
200
300
396 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein transferase MAEA

GID complex subunit 9, FYV10 homolog

Related Diseases

Diseases

Alias

Schizophrenia 16

SCZD16	Schizophrenia Susceptibility Locus, Chromosome 7q36.3-Related
Chromosome 7q36.3 Duplication Syndrome, 362-Kb

Schizophrenia 14

Sczd14	Schizophrenia, Susceptibility To, 14
Schizophrenia Susceptibility Locus, Chromosome 2q32-Related

Retinitis Pigmentosa 42

RP42	Retinitis Pigmentosa-42
Retinitis Pigmentosa, Type 42

Hallucinogen Abuse

Alveolar Echinococcosis

Echinococcus Multilocularis Infection	Echinococcosis
Alveolococcosis	Multilocular Hydatid
Small Fox Tapeworm

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Lissencephaly 1

LIS1	Classic Lissencephaly
Ils	Subcortical Laminar Heterotopia
Lissencephaly Due To Lis1 Mutation	Lissencephaly Sequence, Isolated
Lissencephaly, Classic	Pafah1b1-Related Lissencephaly
Classical Lissencephaly	Lissencephaly Type 1
Lissencephaly-1	Subcortical Band Heterotopia
Double Cortex	Lissencephaly Classic
Lissencephaly Sequence Isolated	Isolated Lissencephaly Sequence
Type 1 Lissencephaly	Lissencephaly Syndrome Type 1
SBH	Sclh
Lissencephaly, Type 1	Type I Lissencephaly

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome	WHS
Chromosome 4p16.3 Deletion Syndrome	Wittwer Syndrome
4p- Syndrome	Pitt Syndrome
4p Deletion Syndrome	Distal Deletion 4p
Distal Monosomy 4p	Telomeric Deletion 4p
Prds	4p Syndrome
Chromosome 4p Syndrome	Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation
Wolf Syndrome	Chromosome 4p Deletion Syndrome
Chromosome 4p Monosomy	Del Syndrome
Monosomy 4p	Partial Monosomy 4p
Chromosome 4 Short Arm Deletion

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07954	MAEA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAEA	MGD	MGI:1891748
Rattus norvegicus	MAEA	RGD	RGD:1309877
Canis familiaris	MAEA	VGNC	VGNC:42918
Bos taurus	MAEA	VGNC	VGNC:31135
Felis catus	MAEA	VGNC	VGNC:63361
Macaca mulatta	MAEA	VGNC	VGNC:74282