Pelo - pelota mRNA surveillance and ribosome rescue factor Gene

Mus musculus

Gene ID: 105083 | Gene type: protein coding

About Pelo

Summary

Predicted to enable Endonuclease activity and metal ion binding activity. Acts upstream of or within several processes, including inner cell mass cell proliferation; mesenchymal to epithelial transition; and positive regulation of BMP signaling pathway. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; limb muscle; orbito-sphenoid; and spleen. Orthologous to human PELO (pelota mRNA surveillance and ribosome rescue factor). [provided by Alliance of Genome Resources, Apr 2022]

Pelo Products(1)

mRNA	Protein	Name
NM_134058.3	NP_598819.2	protein pelota homolog

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25061210	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within chromosome organization	IMP IMP: Inferred from mutant phenotype	12556505	MGI
acts upstream of or within endoderm development	IDA IDA: Inferred from direct assay	24835669	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	24835669	MGI
acts upstream of or within inner cell mass cell proliferation	IMP IMP: Inferred from mutant phenotype	12556505	MGI
acts upstream of or within mesenchymal to epithelial transition	IMP IMP: Inferred from mutant phenotype	24835669	MGI
acts upstream of or within positive regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	24835669	MGI
acts upstream of or within stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	24835669	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein pelota homolog

pelota homolog

Pelo Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Pelo	Q80X73	Hbs1l	Mus musculus	Q69ZS7	Anti Tag CoIP	25061210
Intra	Pelo	Q80X73	Hbs1l	Mus musculus	Q69ZS7	Pull Down	25061210

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-183115	TNG961		/	Unkown
HY-RS10323	PELO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pelo	NCBI	NCBI:53918

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