Pelo - pelota mRNA surveillance and ribosome rescue factor Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 105083

Summary

Predicted to enable Endonuclease activity and metal ion binding activity. Acts upstream of or within several processes, including inner cell mass cell proliferation; mesenchymal to epithelial transition; and positive regulation of BMP signaling pathway. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; limb muscle; orbito-sphenoid; and spleen. Orthologous to human PELO (pelota mRNA surveillance and ribosome rescue factor). [provided by Alliance of Genome Resources, Apr 2022]

Pelo Products (1)

mRNA Protein Name
NM_134058.3 NP_598819.2 protein pelota homolog

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25061210 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chromosome organization IMP
IMP: Inferred from mutant phenotype
12556505 MGI
acts upstream of or within endoderm development IDA
IDA: Inferred from direct assay
24835669 MGI
acts upstream of or within endoderm development IMP
IMP: Inferred from mutant phenotype
24835669 MGI
acts upstream of or within inner cell mass cell proliferation IMP
IMP: Inferred from mutant phenotype
12556505 MGI
acts upstream of or within mesenchymal to epithelial transition IMP
IMP: Inferred from mutant phenotype
24835669 MGI
acts upstream of or within positive regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
24835669 MGI
acts upstream of or within stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
24835669 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein pelota homolog

  • pelota homolog

Pelo Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Pelo Q80X73 Hbs1l Mus musculus Q69ZS7
Anti Tag CoIP
25061210
Intra
Pelo Q80X73 Hbs1l Mus musculus Q69ZS7
Pull Down
25061210
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183115 TNG961 / Unkown
HY-183115A (Rac)-TNG961 / Unkown
HY-RS10323 PELO Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pelo NCBI NCBI:53918