CENPC - centromere protein C Gene

Also Known as MIF2; hcp-4; CENP-C; CENPC1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1060

About CENPC

Cytogenetic location: 4q13.2 Genomic coordinates (GRCh38): 4:67,468,762-67,545,503 (from NCBI)

This gene has 7 transcripts (splice variants) and 117 orthologues. Ubiquitous expression in bone marrow (RPKM 7.9), testis (RPKM 4.6) and 25 other tissues.

Summary

Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]

CENPC Products (2)

mRNA Protein Name
NM_001362481.2 NP_001349410.1 centromere protein C isoform 2
NM_001812.4 NP_001803.2 centromere protein C isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
19503796 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19503796 GOA
Biological Process GO Annotation Evidence References Source
involved in chromosome segregation IMP
IMP: Inferred from mutant phenotype
21529714 GOA
involved in kinetochore assembly IMP
IMP: Inferred from mutant phenotype
21529714 GOA
involved in mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
21529714 GOA
Cellular Component GO Annotation Evidence References Source
located in condensed chromosome, centromeric region IDA
IDA: Inferred from direct assay
11682612 GOA
part of inner kinetochore IPI
IPI: Inferred from physical interaction
36085283 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
21529714 GOA
located in pericentric heterochromatin IDA
IDA: Inferred from direct assay
21529714 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

centromere protein C

  • CENP-C 1

CENPC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CENPC Q03188 CENPA Homo sapiens P49450
BiFC
19503796
Intra
CENPC Q03188 CENPA Homo sapiens P49450
Anti Tag CoIP
19503796
Intra
CENPC Q03188 DSN1 Homo sapiens Q9H410
Anti Tag CoIP
33961781
Intra
CENPC Q03188 DSN1 Homo sapiens Q9H410
Anti Tag CoIP
28514442
Intra
CENPC Q03188 PMF1 Homo sapiens Q6P1K2
Anti Tag CoIP
33961781
Intra
CENPC Q03188 H1-5 Homo sapiens P16401
Crosslink
30021884
Intra
CENPC Q03188 PMF1 Homo sapiens Q6P1K2
Anti Tag CoIP
28514442
Intra
CENPC Q03188 NDC80 Homo sapiens O14777
Anti Tag CoIP
33961781
Intra
CENPC Q03188 MIS12 Homo sapiens Q9H081
Anti Tag CoIP
33961781
Intra
CENPC Q03188 ACTA2 Homo sapiens P62736
Anti Tag CoIP
33961781
Intra
CENPC Q03188 NDC80 Homo sapiens O14777
Anti Tag CoIP
28514442
Intra
CENPC Q03188 MIS12 Homo sapiens Q9H081
Anti Tag CoIP
28514442
Intra
CENPC Q03188 NUF2 Homo sapiens Q9BZD4
Anti Tag CoIP
33961781
Intra
CENPC Q03188 ACTA2 Homo sapiens P62736
Anti Tag CoIP
28514442
Intra
CENPC Q03188 NUF2 Homo sapiens Q9BZD4
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

CENPC Antibodies

Cat. No. Product Name Application Reactivity
HY-P82482 CENPC Antibody (YA2227) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P82482A CENPC Antibody (YA2227)(PBS only) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Hyperinsulinemic Hypoglycemia, Familial, 5

  • Hyperinsulinism Due To Insr Deficiency

  • HHF5

  • Familial Hyperinsulinemic Hypoglycemia 5

  • Hyperinsulinemic Hypoglycemia Due To Insr Deficiency

  • Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency

  • Congenital Hyperinsulinism

  • Persistent Hyperinsulinemic Hypoglycemia Of Infancy

  • Phhi

  • Hyperinsulinemic Hypoglycemia Familial 5
Crest Syndrome
Cowden Syndrome 1

  • Bannayan-Riley-Ruvalcaba Syndrome

  • Pten Hamartoma Tumor Syndrome

  • Lhermitte-Duclos Disease

  • Bannayan-Zonana Syndrome

  • Phts

  • Riley-Smith Syndrome

  • Bzs

  • Ruvalcaba-Myhre-Smith Syndrome

  • Multiple Hamartoma Syndrome

  • Rmss

  • Brrs

  • Dysplastic Gangliocytoma Of The Cerebellum

  • CWS1

  • Cs

  • Cd

  • Mham

  • Pten Hamartoma Tumor Syndrome With Granular Cell Tumor

  • Macrocephaly Multiple Lipomas And Hemangiomata

  • Bannayan-Ruvalcaba-Riley Syndrome

  • Myhre-Riley-Smith Syndrome

  • LDD

  • Cerebelloparenchymal Disorder Vi

  • Hamartoma Syndrome, Multiple

  • Bbrs

  • Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata

  • Macrocephaly, Multiple Lipomas, And Hemangiomata

  • Macrocephaly Pseudopapilledema And Multiple Hemangiomas

  • Ruvalcaba -Myhre-Smith Syndrome

  • Ruvalcaba-Myhre Syndrome

  • Cowden Disease

  • Macrocephaly Pseudopapilledema And Multiple Hemangiomata

  • Cerebellar Granule Cell Hypertrophy And Megalencephaly

  • Cpd6

  • Pten Hamartoma Tumor Syndromes

  • Cowden Syndrome, Type 1
Limited Scleroderma

  • Limited Cutaneous Systemic Sclerosis

  • Limited Systemic Sclerosis

  • Systemic Sclerosis Sine Scleroderma

  • Crest Syndrome

  • Limited Cutaneous Systemic Scleroderma

  • Scleroderma, Limited

  • Systemic Sclerosis, Limited

  • Progressive Systemic Sclerosis Sine Scleroderma

  • Scleroderma, Sine

  • Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome

  • Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Dyskinesia Of Esophagus

  • Esophageal Motility Disorders

  • Dyskinesia Of Oesophagus

  • Esophageal Dysmotility

  • Esophageal Motility Disorder

  • Oesophageal Dysmotility

  • Oesophageal Motor Disorder

  • Esophageal Spasm
Glanders

  • Farcy Pipes

  • Infection Due To Pseudomonas Mallei

  • Burkholderia Mallei

  • Burkholderia Mallei Infection

  • Equina

  • Equine Glanders

  • Farcy

  • Farcy Buds

  • Farcy Cords

  • Infection Due To Actinobacillus Mallei

  • Infection Due To Malleomyces Mallei

  • Maliasmus

  • Malleus

  • Farce

  • Actinobacillosis

  • Actinobacillus Infection
Cowden Syndrome

  • Cowden Disease

  • Multiple Hamartoma Syndrome

  • Cowden'S Disease

  • Lhermitte-Duclos Disease

  • Cd

  • Cs

  • Mham

  • Dysplastic Gangliocytoma Of Cerebellum

  • Cowden'S Syndrome

  • Hamartoma Syndrome, Multiple
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02475 CENPC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CENPC VGNC VGNC:27174
Mus musculus CENPC MGD MGI:99700
Canis familiaris CENPC VGNC VGNC:39102
Rattus norvegicus CENPC RGD RGD:1303061
Macaca mulatta CENPC VGNC VGNC:71007
Felis catus CENPC VGNC VGNC:60753
Others CENPC NCBI