2. Gene
  3. H1-5 - H1.5 linker histone, cluster member Gene

H1-5 - H1.5 linker histone, cluster member Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as H1; H1B; H1.5; H1F5; H1s-3; HIST1H1B

Gene ID: 3009 | Gene type: protein coding

About H1-5

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:27,866,792-27,867,588 (from NCBI)

This gene has 1 transcript (splice variant), 81 orthologues and 9 paralogues.

Summary

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

H1-5 Products(1)

mRNA Protein Name
NM_005322.3 NP_005313.1 histone H1.5

H1-5 Protein Structure

Linker_histone

Linker_histone: linker histone H1 and H5 family (41 - 112)

  • 0
  • 100
  • 200
  • 226 a.a.
Protein Preferred Names Protein Names

histone H1.5

H1 histone family, member 5

Related Diseases

Diseases Alias
Retinitis Pigmentosa 18

RP18

Retinitis Pigmentosa-18

Retinitis Pigmentosa, Type 18
Tonsil Squamous Cell Carcinoma

Tonsillar Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Palatine Tonsil
Rumination Disorder

Rumination Syndrome

Psychogenic Rumination

Rumination Disorders
Paraphilia Disorder

Paraphilia

Paraphilias
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14541 Olanzapine 99.83% Yes
HY-14541R Olanzapine (Standard) / Unkown
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14541S Olanzapine-d3 99.09% Unkown
HY-118110 MLS000545091 Inhibitor 99.92% Unkown
HY-116124 17(S)-HpDHA / Unkown
HY-153930 h15-LOX-2 inhibitor 1 Inhibitor / Unkown
HY-RS05950 H1-5 Human Pre-designed siRNA Set A / Unkown
HY-W016622 Watermelon ketone 99.95% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus H1-5 RGD RGD:1590638
Felis catus H1-5 VGNC VGNC:109860
Macaca mulatta H1-5 VGNC VGNC:109746
Mus musculus H1-5 MGD MGI:1861461