H1-5 - H1.5 linker histone, cluster member Gene

Also Known as H1; H1B; H1.5; H1F5; H1s-3; HIST1H1B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3009

About H1-5

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:27,866,792-27,867,588 (from NCBI)

This gene has 1 transcript (splice variant), 81 orthologues and 9 paralogues.

Summary

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

H1-5 Products (1)

mRNA Protein Name
NM_005322.3 NP_005313.1 histone H1.5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin DNA binding IMP
IMP: Inferred from mutant phenotype
15911621 GOA
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
22956909 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26496610 GOA
Biological Process GO Annotation Evidence References Source
involved in chromatin organization IMP
IMP: Inferred from mutant phenotype
22956909 GOA
involved in establishment of protein localization to chromatin IMP
IMP: Inferred from mutant phenotype
22956909 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22956909 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
22956909 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
19882353 GOA
located in heterochromatin IDA
IDA: Inferred from direct assay
15911621 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21383955 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H1-5 Protein Structure

Linker_histone

Linker_histone: linker histone H1 and H5 family (41 - 112)

  • 0
  • 100
  • 200
  • 226 a.a.
Protein Preferred Names Protein Names

histone H1.5

  • H1 histone family, member 5

H1-5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
H1-5 P16401 DHX30 Homo sapiens Q7L2E3
Anti Tag CoIP
33961781
Intra
H1-5 P16401 H2AC21 Homo sapiens Q8IUE6
Crosslink
30021884
Intra
H1-5 P16401 H2AC21 Homo sapiens Q8IUE6
Anti Tag CoIP
33961781
Intra
H1-5 P16401 CENPC Homo sapiens Q03188
Anti Tag CoIP
33961781
Intra
H1-5 P16401 NCL Homo sapiens P19338
Anti Tag CoIP
33961781
Intra
H1-5 P16401 RPS19 Homo sapiens P39019
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinitis Pigmentosa 18

  • RP18

  • Retinitis Pigmentosa-18

  • Retinitis Pigmentosa, Type 18
Tonsil Squamous Cell Carcinoma

  • Tonsillar Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Palatine Tonsil
Rumination Disorder

  • Rumination Syndrome

  • Psychogenic Rumination

  • Rumination Disorders
Paraphilia Disorder

  • Paraphilia

  • Paraphilias
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14541 Olanzapine 99.96% Yes
HY-B2169 Melperone 99.84% Yes
HY-14541R Olanzapine (Standard) 99.98% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-14541A Olanzapine hydrochloride / Phase 4
HY-103109 Melperone hydrochloride / Phase 3
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991067 Vensobafusp alfa Inhibitor 97% Phase 2

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-20007 2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine 99.78% Unkown
HY-20006 2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine (hydrochlortde) 99.99% Unkown
HY-W016622 Watermelon ketone 99.95% Unkown
HY-14541S Olanzapine-d3 99.78% Unkown
HY-116124 17(S)-HpDHA 99.48% Unkown
HY-116919 MLS000536924 Inhibitor 98.20% Unkown
HY-118110 MLS000545091 Inhibitor 99.92% Unkown
HY-14541S2 Olanzapine-d8 99.9% Unkown
HY-153930 h15-LOX-2 inhibitor 1 Inhibitor / Unkown
HY-178113 15-PGDH-IN-4 Inhibitor / Unkown
HY-RS05950 H1-5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-161907 h15-LOX-2 inhibitor 2 Inhibitor / Unkown
HY-161908 h15-LOX-2 inhibitor 3 Inhibitor / Unkown
HY-B2169S2 Melperone-d4 hydrochloride 99.84% Unkown
HY-W016622R Watermelon ketone (Standard) / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus H1-5 RGD RGD:1590638
Felis catus H1-5 VGNC VGNC:109860
Macaca mulatta H1-5 VGNC VGNC:109746
Mus musculus H1-5 MGD MGI:1861461
Others H1-5 NCBI