2. Metabolic Enzyme/Protease
  3. Lipoxygenase
  4. MLS000536924

MLS000536924 is a potent and selective inhibitor of human epithelial 15-lipoxygenase-2 with competitive activity. MLS000536924 exhibits more than 50-fold selectivity in inhibiting h15-LOX-2 and can be effectively applied to study its role in atherosclerosis, cystic fibrosis, and ferroptosis. The binding mode of MLS000536924 shows stronger restriction of protein movement than other inhibitors, further verifying its higher biological activity.

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MLS000536924

MLS000536924 Chemical Structure

CAS No. : 511306-37-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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MLS000536924 Related Antibodies

Top Publications Citing Use of Products

View All Lipoxygenase Isoform Specific Products:

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5-LOX 12-LOX 15-LOX

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Description

MLS000536924 is a potent and selective inhibitor of human epithelial 15-lipoxygenase-2 with competitive activity. MLS000536924 exhibits more than 50-fold selectivity in inhibiting h15-LOX-2 and can be effectively applied to study its role in atherosclerosis, cystic fibrosis, and ferroptosis. The binding mode of MLS000536924 shows stronger restriction of protein movement than other inhibitors, further verifying its higher biological activity[1].

Molecular Weight

281.38

Formula

C16H15N3S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1=CC=C(C=C1)CSC2=NN(C=N2)C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (355.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5539 mL 17.7696 mL 35.5391 mL
5 mM 0.7108 mL 3.5539 mL 7.1078 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5539 mL 17.7696 mL 35.5391 mL 88.8478 mL
5 mM 0.7108 mL 3.5539 mL 7.1078 mL 17.7696 mL
10 mM 0.3554 mL 1.7770 mL 3.5539 mL 8.8848 mL
15 mM 0.2369 mL 1.1846 mL 2.3693 mL 5.9232 mL
20 mM 0.1777 mL 0.8885 mL 1.7770 mL 4.4424 mL
25 mM 0.1422 mL 0.7108 mL 1.4216 mL 3.5539 mL
30 mM 0.1185 mL 0.5923 mL 1.1846 mL 2.9616 mL
40 mM 0.0888 mL 0.4442 mL 0.8885 mL 2.2212 mL
50 mM 0.0711 mL 0.3554 mL 0.7108 mL 1.7770 mL
60 mM 0.0592 mL 0.2962 mL 0.5923 mL 1.4808 mL
80 mM 0.0444 mL 0.2221 mL 0.4442 mL 1.1106 mL
100 mM 0.0355 mL 0.1777 mL 0.3554 mL 0.8885 mL
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MLS000536924 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MLS000536924511306-37-9MLS 000536924MLS-000536924LipoxygenaseLOXInhibitorinhibitorinhibit

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