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DSN1 - DSN1 component of MIS12 kinetochore complex Gene

Also Known as KNL3; MIS13; hKNL-3; C20orf172; dJ469A13.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79980

About DSN1

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:36,751,795-36,773,763 (from NCBI)

This gene has 10 transcripts (splice variants) and 174 orthologues. Broad expression in testis (RPKM 11.7), lymph node (RPKM 6.7) and 24 other tissues.

Summary

This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

DSN1 Products (5)

mRNA	Protein	Name
NM_001145315.2	NP_001138787.1	kinetochore-associated protein DSN1 homolog isoform 1
NM_001145316.2	NP_001138788.1	kinetochore-associated protein DSN1 homolog isoform 1
NM_001145317.2	NP_001138789.1	kinetochore-associated protein DSN1 homolog isoform 2
NM_001145318.2	NP_001138790.1	kinetochore-associated protein DSN1 homolog isoform 3
NM_024918.4	NP_079194.3	kinetochore-associated protein DSN1 homolog isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15371340	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of MIS12/MIND type complex	IDA IDA: Inferred from direct assay	16585270	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	15371340	GOA
part of outer kinetochore	IDA IDA: Inferred from direct assay	24530301	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DSN1 Protein Structure

MIS13

0
100
200
300
356 a.a.

Protein Preferred Names	Protein Names
kinetochore-associated protein DSN1 homolog	DSN1 homolog, MIS12 kinetochore complex component

DSN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	GMS	23334297
Intra	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	TAP	24981860
Intra	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	Anti Tag CoIP	26496610
Intra	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	TAP	27705803
Intra	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	BRET	37398436
Intra	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	BiLC	37398436
Intra	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	Anti Tag CoIP	33961781
Intra	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	Anti Tag CoIP	28514442
Intra	DSN1	Q9H410	ATP5PB	Homo sapiens	P24539	Y2H Pooling	32814053
Intra	DSN1	Q9H410	ATP5PB	Homo sapiens	P24539	Validated Y2H	32814053
Intra	DSN1	Q9H410	ATP5PB	Homo sapiens	P24539	Y2H Array	32814053
Intra	DSN1	Q9H410	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	DSN1	Q9H410	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	DSN1	Q9H410	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	DSN1	Q9H410	COL26A1	Homo sapiens	Q96A83-2	Y2H Array	32814053
Intra	DSN1	Q9H410	COL26A1	Homo sapiens	Q96A83-2	Y2H Pooling	32814053
Intra	DSN1	Q9H410	COL26A1	Homo sapiens	Q96A83-2	Validated Y2H	32814053
Intra	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	Lumier	37398436
Intra	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	BRET	37398436
Intra	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	GMS	23334297
Intra	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	TAP	24981860
Intra	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	TAP	27705803
Intra	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	BiLC	37398436
Intra	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	Anti Tag CoIP	33961781
Intra	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	Anti Tag CoIP	26496610
Intra	DSN1	Q9H410	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
Intra	DSN1	Q9H410	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
Intra	DSN1	Q9H410	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
Intra	DSN1	Q9H410	ICAM5	Homo sapiens	Q9UMF0	Y2H Pooling	32814053
Intra	DSN1	Q9H410	ICAM5	Homo sapiens	Q9UMF0	Validated Y2H	32814053
Intra	DSN1	Q9H410	ICAM5	Homo sapiens	Q9UMF0	Y2H Array	32814053
Intra	DSN1	Q9H410	BGN	Homo sapiens	P21810	Y2H Array	32814053
Intra	DSN1	Q9H410	BGN	Homo sapiens	P21810	Y2H Pooling	32814053
Intra	DSN1	Q9H410	BGN	Homo sapiens	P21810	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Colon Small Cell Carcinoma	Colonic Small Cell Carcinoma Colon Small Cell Neuroendocrine Carcinoma
Arts Syndrome	ARTS Mrxsarts Ataxia, Fatal X-Linked, With Deafness And Loss Of Vision Mrxs18 Lethal Ataxia With Deafness And Optic Atrophy Fatal X-Linked Ataxia With Deafness And Loss Of Vision Mental Retardation, X-Linked, Syndromic, Arts Type Mental Retardation, X-Linked, Syndromic 18 Syndromic X-Linked Mental Retardation 18 Syndromic X-Linked Mental Retardation Arts Type Lethal Ataxia-Deafness-Optic Atrophy X-Linked Fatal Ataxia With Deafness And Loss Of Vision Ataxia-Deafness-Optic Atrophy, Lethal Lethal Ataxia With Hearing Loss And Optic Atrophy Art

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04025	DSN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DSN1	VGNC	VGNC:71846
Canis familiaris	DSN1	VGNC	VGNC:40109
Bos taurus	DSN1	VGNC	VGNC:28224
Mus musculus	DSN1	MGD	MGI:1914184
Felis catus	DSN1	VGNC	VGNC:61639
Rattus norvegicus	DSN1	RGD	RGD:1565179
Others	DSN1	NCBI