DSN1 - DSN1 component of MIS12 kinetochore complex Gene

Homo sapiens

Also known as KNL3; MIS13; hKNL-3; C20orf172; dJ469A13.2

Gene ID: 79980 | Gene type: protein coding

About DSN1

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:36,751,795-36,773,763 (from NCBI)

This gene has 10 transcripts (splice variants) and 174 orthologues. Broad expression in testis (RPKM 11.7), lymph node (RPKM 6.7) and 24 other tissues.

Summary

This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

DSN1 Products(5)

mRNA	Protein	Name
NM_001145315.2	NP_001138787.1	kinetochore-associated protein DSN1 homolog isoform 1
NM_001145316.2	NP_001138788.1	kinetochore-associated protein DSN1 homolog isoform 1
NM_001145317.2	NP_001138789.1	kinetochore-associated protein DSN1 homolog isoform 2
NM_001145318.2	NP_001138790.1	kinetochore-associated protein DSN1 homolog isoform 3
NM_024918.4	NP_079194.3	kinetochore-associated protein DSN1 homolog isoform 1

DSN1 Protein Structure

MIS13

0
100
200
300
356 a.a.

Protein Preferred Names

Protein Names

kinetochore-associated protein DSN1 homolog

DSN1 homolog, MIS12 kinetochore complex component

Related Diseases

Diseases

Alias

Colon Small Cell Carcinoma

Colonic Small Cell Carcinoma

Colon Small Cell Neuroendocrine Carcinoma

Arts Syndrome

ARTS	Mrxsarts
Ataxia, Fatal X-Linked, With Deafness And Loss Of Vision	Mrxs18
Lethal Ataxia With Deafness And Optic Atrophy	Fatal X-Linked Ataxia With Deafness And Loss Of Vision
Mental Retardation, X-Linked, Syndromic, Arts Type	Mental Retardation, X-Linked, Syndromic 18
Syndromic X-Linked Mental Retardation 18	Syndromic X-Linked Mental Retardation Arts Type
Lethal Ataxia-Deafness-Optic Atrophy	X-Linked Fatal Ataxia With Deafness And Loss Of Vision
Ataxia-Deafness-Optic Atrophy, Lethal	Lethal Ataxia With Hearing Loss And Optic Atrophy
Art

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04025	DSN1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DSN1	VGNC	VGNC:71846
Canis familiaris	DSN1	VGNC	VGNC:40109
Bos taurus	DSN1	VGNC	VGNC:28224
Mus musculus	DSN1	MGD	MGI:1914184
Felis catus	DSN1	VGNC	VGNC:61639
Rattus norvegicus	DSN1	RGD	RGD:1565179