CELF1 - CUGBP Elav-like family member 1 Gene

Also Known as CUGBP; NAB50; NAPOR; CUG-BP; CUGBP1; hNab50; BRUNOL2; EDEN-BP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10658

About CELF1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,465,937-47,565,539 (from NCBI)

This gene has 22 transcripts (splice variants), 220 orthologues and 6 paralogues. Ubiquitous expression in lymph node (RPKM 13.4), spleen (RPKM 12.7) and 25 other tissues.

Summary

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

CELF1 Products (91)

mRNA Protein Name
NM_001025596.3 NP_001020767.1 CUGBP Elav-like family member 1 isoform 3
NM_001172639.2 NP_001166110.1 CUGBP Elav-like family member 1 isoform 4
NM_001172640.2 NP_001166111.1 CUGBP Elav-like family member 1 isoform 5
NM_001330272.2 NP_001317201.1 CUGBP Elav-like family member 1 isoform 6
NM_001376369.1 NP_001363298.1 CUGBP Elav-like family member 1 isoform 6
NM_001376370.1 NP_001363299.1 CUGBP Elav-like family member 1 isoform 6
NM_001376371.1 NP_001363300.1 CUGBP Elav-like family member 1 isoform 6
NM_001376372.1 NP_001363301.1 CUGBP Elav-like family member 1 isoform 6
NM_001376373.1 NP_001363302.1 CUGBP Elav-like family member 1 isoform 6
NM_001376374.1 NP_001363303.1 CUGBP Elav-like family member 1 isoform 6
NM_001376375.1 NP_001363304.1 CUGBP Elav-like family member 1 isoform 6
NM_001376376.1 NP_001363305.1 CUGBP Elav-like family member 1 isoform 6
NM_001376377.1 NP_001363306.1 CUGBP Elav-like family member 1 isoform 7
NM_001376378.1 NP_001363307.1 CUGBP Elav-like family member 1 isoform 7
NM_001376379.1 NP_001363308.1 CUGBP Elav-like family member 1 isoform 7
NM_001376380.1 NP_001363309.1 CUGBP Elav-like family member 1 isoform 7
NM_001376381.1 NP_001363310.1 CUGBP Elav-like family member 1 isoform 7
NM_001376382.1 NP_001363311.1 CUGBP Elav-like family member 1 isoform 24
NM_001376383.1 NP_001363312.1 CUGBP Elav-like family member 1 isoform 7
NM_001376384.1 NP_001363313.1 CUGBP Elav-like family member 1 isoform 4
NM_001376385.1 NP_001363314.1 CUGBP Elav-like family member 1 isoform 8
NM_001376386.1 NP_001363315.1 CUGBP Elav-like family member 1 isoform 8
NM_001376387.1 NP_001363316.1 CUGBP Elav-like family member 1 isoform 9
NM_001376388.1 NP_001363317.1 CUGBP Elav-like family member 1 isoform 9
NM_001376389.1 NP_001363318.1 CUGBP Elav-like family member 1 isoform 9
NM_001376390.1 NP_001363319.1 CUGBP Elav-like family member 1 isoform 9
NM_001376391.1 NP_001363320.1 CUGBP Elav-like family member 1 isoform 9
NM_001376393.1 NP_001363322.1 CUGBP Elav-like family member 1 isoform 10
NM_001376395.1 NP_001363324.1 CUGBP Elav-like family member 1 isoform 10
NM_001376396.1 NP_001363325.1 CUGBP Elav-like family member 1 isoform 10
NM_001376397.1 NP_001363326.1 CUGBP Elav-like family member 1 isoform 10
NM_001376399.1 NP_001363328.1 CUGBP Elav-like family member 1 isoform 10
NM_001376406.1 NP_001363335.1 CUGBP Elav-like family member 1 isoform 10
NM_001376407.1 NP_001363336.1 CUGBP Elav-like family member 1 isoform 10
NM_001376408.1 NP_001363337.1 CUGBP Elav-like family member 1 isoform 10
NM_001376409.1 NP_001363338.1 CUGBP Elav-like family member 1 isoform 10
NM_001376410.1 NP_001363339.1 CUGBP Elav-like family member 1 isoform 10
NM_001376411.1 NP_001363340.1 CUGBP Elav-like family member 1 isoform 10
NM_001376412.1 NP_001363341.1 CUGBP Elav-like family member 1 isoform 10
NM_001376413.1 NP_001363342.1 CUGBP Elav-like family member 1 isoform 10
NM_001376414.1 NP_001363343.1 CUGBP Elav-like family member 1 isoform 10
NM_001376415.1 NP_001363344.1 CUGBP Elav-like family member 1 isoform 3
NM_001376417.1 NP_001363346.1 CUGBP Elav-like family member 1 isoform 3
NM_001376418.1 NP_001363347.1 CUGBP Elav-like family member 1 isoform 3
NM_001376419.1 NP_001363348.1 CUGBP Elav-like family member 1 isoform 3
NM_001376420.1 NP_001363349.1 CUGBP Elav-like family member 1 isoform 3
NM_001376421.1 NP_001363350.1 CUGBP Elav-like family member 1 isoform 3
NM_001376422.1 NP_001363351.1 CUGBP Elav-like family member 1 isoform 3
NM_001376423.1 NP_001363352.1 CUGBP Elav-like family member 1 isoform 23
NM_001376424.1 NP_001363353.1 CUGBP Elav-like family member 1 isoform 3
NM_001376425.1 NP_001363354.1 CUGBP Elav-like family member 1 isoform 3
NM_001376426.1 NP_001363355.1 CUGBP Elav-like family member 1 isoform 3
NM_001376427.1 NP_001363356.1 CUGBP Elav-like family member 1 isoform 3
NM_001376428.1 NP_001363357.1 CUGBP Elav-like family member 1 isoform 3
NM_001376429.1 NP_001363358.1 CUGBP Elav-like family member 1 isoform 3
NM_001376430.1 NP_001363359.1 CUGBP Elav-like family member 1 isoform 3
NM_001376431.1 NP_001363360.1 CUGBP Elav-like family member 1 isoform 5
NM_001376432.1 NP_001363361.1 CUGBP Elav-like family member 1 isoform 11
NM_001376433.1 NP_001363362.1 CUGBP Elav-like family member 1 isoform 11
NM_001376434.1 NP_001363363.1 CUGBP Elav-like family member 1 isoform 2
NM_001376435.1 NP_001363364.1 CUGBP Elav-like family member 1 isoform 2
NM_001376436.1 NP_001363365.1 CUGBP Elav-like family member 1 isoform 2
NM_001376437.1 NP_001363366.1 CUGBP Elav-like family member 1 isoform 2
NM_001376438.1 NP_001363367.1 CUGBP Elav-like family member 1 isoform 2
NM_001376439.1 NP_001363368.1 CUGBP Elav-like family member 1 isoform 2
NM_001376440.1 NP_001363369.1 CUGBP Elav-like family member 1 isoform 2
NM_001376441.1 NP_001363370.1 CUGBP Elav-like family member 1 isoform 2
NM_001376442.1 NP_001363371.1 CUGBP Elav-like family member 1 isoform 1
NM_001376443.1 NP_001363372.1 CUGBP Elav-like family member 1 isoform 1
NM_001376444.1 NP_001363373.1 CUGBP Elav-like family member 1 isoform 1
NM_001376445.1 NP_001363374.1 CUGBP Elav-like family member 1 isoform 1
NM_001376446.1 NP_001363375.1 CUGBP Elav-like family member 1 isoform 1
NM_001376447.1 NP_001363376.1 CUGBP Elav-like family member 1 isoform 22
NM_001376448.1 NP_001363377.1 CUGBP Elav-like family member 1 isoform 1
NM_001376449.1 NP_001363378.1 CUGBP Elav-like family member 1 isoform 1
NM_001376450.1 NP_001363379.1 CUGBP Elav-like family member 1 isoform 12
NM_001376451.1 NP_001363380.1 CUGBP Elav-like family member 1 isoform 13
NM_001376452.1 NP_001363381.1 CUGBP Elav-like family member 1 isoform 14
NM_001376453.1 NP_001363382.1 CUGBP Elav-like family member 1 isoform 15
NM_001376454.1 NP_001363383.1 CUGBP Elav-like family member 1 isoform 16
NM_001376455.1 NP_001363384.1 CUGBP Elav-like family member 1 isoform 25
NM_001376456.1 NP_001363385.1 CUGBP Elav-like family member 1 isoform 17
NM_001376457.1 NP_001363386.1 CUGBP Elav-like family member 1 isoform 17
NM_001376458.1 NP_001363387.1 CUGBP Elav-like family member 1 isoform 18
NM_001376459.1 NP_001363388.1 CUGBP Elav-like family member 1 isoform 19
NM_001376460.1 NP_001363389.1 CUGBP Elav-like family member 1 isoform 19
NM_001376461.1 NP_001363390.1 CUGBP Elav-like family member 1 isoform 20
NM_001376462.1 NP_001363391.1 CUGBP Elav-like family member 1 isoform 20
NM_001376463.1 NP_001363392.1 CUGBP Elav-like family member 1 isoform 21
NM_006560.4 NP_006551.1 CUGBP Elav-like family member 1 isoform 1
NM_198700.3 NP_941989.1 CUGBP Elav-like family member 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables BRE binding IDA
IDA: Inferred from direct assay
10893231 GOA
enables RNA binding IDA
IDA: Inferred from direct assay
16946708 GOA
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
30508596 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
14726956 GOA
enables pre-mRNA binding IDA
IDA: Inferred from direct assay
11158314 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16946708 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA splice site recognition IDA
IDA: Inferred from direct assay
11158314 GOA
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
27230130 GOA
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
26366374 GOA
involved in post-transcriptional gene silencing IDA
IDA: Inferred from direct assay
30508596 GOA
involved in regulation of RNA splicing IDA
IDA: Inferred from direct assay
16946708 GOA
acts upstream of or within regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
27230130 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
18164289 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11158314 GOA
located in perinucleolar compartment IDA
IDA: Inferred from direct assay
18164289 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CELF1 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (19 - 84)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (110 - 175)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (403 - 472)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 486 a.a.
Protein Preferred Names Protein Names

CUGBP Elav-like family member 1

  • 50 kDa nuclear polyadenylated RNA-binding protein

CELF1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83061 CUG BP1 Antibody (YA2806) WB, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Myotonic Dystrophy 1

  • Myotonic Dystrophy

  • Dystrophia Myotonica

  • Steinert Disease

  • Myotonic Dystrophy Type 1

  • Myotonia Atrophica

  • DM1

  • Congenital Myotonic Dystrophy

  • Myotonia Dystrophica

  • Steinert Myotonic Dystrophy

  • Dystrophia Myotonica 1

  • Dm

  • Steinert'S Disease

  • Steinert Myotonic Dystrophy Syndrome

  • Myotonic Dystrophy Of Steinert

  • Dystrophia Myotonica Type 1

  • Myotonic Dystrophy Congenital

  • Dystrophy, Myotonic, Type 1

  • Dm - [Dystrophia Myotonica]

  • Myotonic Muscular Dystrophy
Myotonic Disease

  • Myotonic Disorders

  • Myotonic Syndrome

  • Symptomatic Myotonia
Myotonic Dystrophy 2

  • Myotonic Dystrophy Type 2

  • Proximal Myotonic Myopathy

  • Promm

  • Ricker Syndrome

  • DM2

  • Dystrophia Myotonica 2

  • Myotonic Myopathy, Proximal

  • Myotonic Disorders

  • Dystrophia Myotonica Type 2

  • Proximal Myotonic Dystrophy

  • Ricker Disease

  • Myotonic Dystrophy, Type 2

  • Dystrophy, Myotonic, Type 2
X-Linked Hereditary Ataxia
Fragile X-Associated Tremor/Ataxia Syndrome

  • Fxtas Syndrome

  • Fragile X Tremor/Ataxia Syndrome

  • Fxtas
Spinocerebellar Ataxia 8

  • Spinocerebellar Ataxia Type 8

  • SCA8

  • Ataxia, Spinocerebellar, Type 8
Huntington Disease-Like 2

  • HDL2

  • Huntington'S Disease-Like 2

  • Huntington Disease-Like, Type 2
Muscular Dystrophy

  • Muscular Dystrophies

  • Congenital Md

  • Congenital Muscular Dystrophy

  • Cmd

  • Mdc

  • Dystrophy, Muscular

  • Gower'S Muscular Dystrophy

  • Progressive Musclular Dystrophy

  • Pseudohypertrophic Atrophy

  • Pseudohypertrophic Muscle Paralysis

  • Pseudohypertrophic Muscular Atrophy

  • Pseudohypertrophic Muscular Dystrophy

  • Pseudohypertrophic Paralysis

  • Pseudomuscular Hypertrophy
Oculopharyngeal Muscular Dystrophy

  • OPMD

  • Muscular Dystrophy, Oculopharyngeal

  • Dystrophy, Oculopharyngeal Muscular

  • Oculopharyngeal Dystrophy

  • Progressive Muscular Dystrophy, Oculopharyngeal Type

  • Muscular Dystrophy Oculopharyngeal

  • Dystrophy, Muscular, Oculopharyngeal
Spinal And Bulbar Muscular Atrophy, X-Linked 1

  • Kennedy Disease

  • Sbma

  • Spinal And Bulbar Muscular Atrophy

  • Kennedy'S Disease

  • X-Linked Spinal And Bulbar Muscular Atrophy

  • SMAX1

  • Kd

  • Kennedy Spinal And Bulbar Muscular Atrophy

  • Spinobulbar Muscular Atrophy

  • Bulbospinal Muscular Atrophy, X-Linked

  • Bulbospinal Neuronopathy, X-Linked Recessive

  • Xbsn

  • Spinal And Bulbar Muscular Atrophy Of Kennedy

  • Bulbospinal Muscular Atrophy

  • X-Linked Bulbospinal Amyotrophy

  • Bulbo-Spinal Atrophy, X-Linked

  • Spinal Bulbar Muscular Atrophy

  • X-Linked Bulbo-Spinal Atrophy

  • X-Linked Spinal Bulbar Muscular Atrophy

  • X-Linked Bsma

  • X-Linked Bulbospinal Muscular Atrophy

  • Spinal And Bulbar Muscular Atrophy X-Linked 1

  • Bulbospinal Muscular Atrophy X-Linked

  • Bulbospinal Neuronopathy X-Linked Recessive

  • Kennedy Disease)

  • Kennedy Syndrome

  • Atrophy, Muscular, Spinal And Bulbar, Kennedy Type

  • Atrophy, Muscular, Spinobulbar

  • Bulbospinal Neuronopathy
Lens Disease

  • Lens Diseases
Neuromuscular Disease

  • Neuromuscular Diseases

  • Neuromuscular Disorders

  • Neuromuscular Disorder
Autosomal Dominant Cerebellar Ataxia

  • Spinocerebellar Ataxia

  • Adca

  • Pierre Marie Cerebellar Ataxia

  • Ataxia, Spinocerebellar

  • Sca

  • Autosomal Dominant Spinocerebellar Ataxia

  • Spinocerebellar Ataxias
Myopathy

  • Muscular Diseases

  • Myopathies
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02459 CELF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22429 Celf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28952 Celf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CELF1 VGNC VGNC:60744
Rattus norvegicus CELF1 RGD RGD:1307721
Bos taurus CELF1 VGNC VGNC:27167
Mus musculus CELF1 MGD MGI:1342295
Canis familiaris CELF1 VGNC VGNC:39093
Macaca mulatta CELF1 VGNC VGNC:71098