2. Gene
  3. CELF1 - CUGBP Elav-like family member 1 Gene

CELF1 - CUGBP Elav-like family member 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CUGBP; NAB50; NAPOR; CUG-BP; CUGBP1; hNab50; BRUNOL2; EDEN-BP

Gene ID: 10658 | Gene type: protein coding

About CELF1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,465,937-47,565,539 (from NCBI)

This gene has 22 transcripts (splice variants), 220 orthologues and 6 paralogues. Ubiquitous expression in lymph node (RPKM 13.4), spleen (RPKM 12.7) and 25 other tissues.

Summary

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

CELF1 Products(91)

mRNA Protein Name
NM_001025596.3 NP_001020767.1 CUGBP Elav-like family member 1 isoform 3
NM_001172639.2 NP_001166110.1 CUGBP Elav-like family member 1 isoform 4
NM_001172640.2 NP_001166111.1 CUGBP Elav-like family member 1 isoform 5
NM_001330272.2 NP_001317201.1 CUGBP Elav-like family member 1 isoform 6
NM_001376369.1 NP_001363298.1 CUGBP Elav-like family member 1 isoform 6
NM_001376370.1 NP_001363299.1 CUGBP Elav-like family member 1 isoform 6
NM_001376371.1 NP_001363300.1 CUGBP Elav-like family member 1 isoform 6
NM_001376372.1 NP_001363301.1 CUGBP Elav-like family member 1 isoform 6
NM_001376373.1 NP_001363302.1 CUGBP Elav-like family member 1 isoform 6
NM_001376374.1 NP_001363303.1 CUGBP Elav-like family member 1 isoform 6
NM_001376375.1 NP_001363304.1 CUGBP Elav-like family member 1 isoform 6
NM_001376376.1 NP_001363305.1 CUGBP Elav-like family member 1 isoform 6
NM_001376377.1 NP_001363306.1 CUGBP Elav-like family member 1 isoform 7
NM_001376378.1 NP_001363307.1 CUGBP Elav-like family member 1 isoform 7
NM_001376379.1 NP_001363308.1 CUGBP Elav-like family member 1 isoform 7
NM_001376380.1 NP_001363309.1 CUGBP Elav-like family member 1 isoform 7
NM_001376381.1 NP_001363310.1 CUGBP Elav-like family member 1 isoform 7
NM_001376382.1 NP_001363311.1 CUGBP Elav-like family member 1 isoform 24
NM_001376383.1 NP_001363312.1 CUGBP Elav-like family member 1 isoform 7
NM_001376384.1 NP_001363313.1 CUGBP Elav-like family member 1 isoform 4
NM_001376385.1 NP_001363314.1 CUGBP Elav-like family member 1 isoform 8
NM_001376386.1 NP_001363315.1 CUGBP Elav-like family member 1 isoform 8
NM_001376387.1 NP_001363316.1 CUGBP Elav-like family member 1 isoform 9
NM_001376388.1 NP_001363317.1 CUGBP Elav-like family member 1 isoform 9
NM_001376389.1 NP_001363318.1 CUGBP Elav-like family member 1 isoform 9
NM_001376390.1 NP_001363319.1 CUGBP Elav-like family member 1 isoform 9
NM_001376391.1 NP_001363320.1 CUGBP Elav-like family member 1 isoform 9
NM_001376393.1 NP_001363322.1 CUGBP Elav-like family member 1 isoform 10
NM_001376395.1 NP_001363324.1 CUGBP Elav-like family member 1 isoform 10
NM_001376396.1 NP_001363325.1 CUGBP Elav-like family member 1 isoform 10
NM_001376397.1 NP_001363326.1 CUGBP Elav-like family member 1 isoform 10
NM_001376399.1 NP_001363328.1 CUGBP Elav-like family member 1 isoform 10
NM_001376406.1 NP_001363335.1 CUGBP Elav-like family member 1 isoform 10
NM_001376407.1 NP_001363336.1 CUGBP Elav-like family member 1 isoform 10
NM_001376408.1 NP_001363337.1 CUGBP Elav-like family member 1 isoform 10
NM_001376409.1 NP_001363338.1 CUGBP Elav-like family member 1 isoform 10
NM_001376410.1 NP_001363339.1 CUGBP Elav-like family member 1 isoform 10
NM_001376411.1 NP_001363340.1 CUGBP Elav-like family member 1 isoform 10
NM_001376412.1 NP_001363341.1 CUGBP Elav-like family member 1 isoform 10
NM_001376413.1 NP_001363342.1 CUGBP Elav-like family member 1 isoform 10
NM_001376414.1 NP_001363343.1 CUGBP Elav-like family member 1 isoform 10
NM_001376415.1 NP_001363344.1 CUGBP Elav-like family member 1 isoform 3
NM_001376417.1 NP_001363346.1 CUGBP Elav-like family member 1 isoform 3
NM_001376418.1 NP_001363347.1 CUGBP Elav-like family member 1 isoform 3
NM_001376419.1 NP_001363348.1 CUGBP Elav-like family member 1 isoform 3
NM_001376420.1 NP_001363349.1 CUGBP Elav-like family member 1 isoform 3
NM_001376421.1 NP_001363350.1 CUGBP Elav-like family member 1 isoform 3
NM_001376422.1 NP_001363351.1 CUGBP Elav-like family member 1 isoform 3
NM_001376423.1 NP_001363352.1 CUGBP Elav-like family member 1 isoform 23
NM_001376424.1 NP_001363353.1 CUGBP Elav-like family member 1 isoform 3
NM_001376425.1 NP_001363354.1 CUGBP Elav-like family member 1 isoform 3
NM_001376426.1 NP_001363355.1 CUGBP Elav-like family member 1 isoform 3
NM_001376427.1 NP_001363356.1 CUGBP Elav-like family member 1 isoform 3
NM_001376428.1 NP_001363357.1 CUGBP Elav-like family member 1 isoform 3
NM_001376429.1 NP_001363358.1 CUGBP Elav-like family member 1 isoform 3
NM_001376430.1 NP_001363359.1 CUGBP Elav-like family member 1 isoform 3
NM_001376431.1 NP_001363360.1 CUGBP Elav-like family member 1 isoform 5
NM_001376432.1 NP_001363361.1 CUGBP Elav-like family member 1 isoform 11
NM_001376433.1 NP_001363362.1 CUGBP Elav-like family member 1 isoform 11
NM_001376434.1 NP_001363363.1 CUGBP Elav-like family member 1 isoform 2
NM_001376435.1 NP_001363364.1 CUGBP Elav-like family member 1 isoform 2
NM_001376436.1 NP_001363365.1 CUGBP Elav-like family member 1 isoform 2
NM_001376437.1 NP_001363366.1 CUGBP Elav-like family member 1 isoform 2
NM_001376438.1 NP_001363367.1 CUGBP Elav-like family member 1 isoform 2
NM_001376439.1 NP_001363368.1 CUGBP Elav-like family member 1 isoform 2
NM_001376440.1 NP_001363369.1 CUGBP Elav-like family member 1 isoform 2
NM_001376441.1 NP_001363370.1 CUGBP Elav-like family member 1 isoform 2
NM_001376442.1 NP_001363371.1 CUGBP Elav-like family member 1 isoform 1
NM_001376443.1 NP_001363372.1 CUGBP Elav-like family member 1 isoform 1
NM_001376444.1 NP_001363373.1 CUGBP Elav-like family member 1 isoform 1
NM_001376445.1 NP_001363374.1 CUGBP Elav-like family member 1 isoform 1
NM_001376446.1 NP_001363375.1 CUGBP Elav-like family member 1 isoform 1
NM_001376447.1 NP_001363376.1 CUGBP Elav-like family member 1 isoform 22
NM_001376448.1 NP_001363377.1 CUGBP Elav-like family member 1 isoform 1
NM_001376449.1 NP_001363378.1 CUGBP Elav-like family member 1 isoform 1
NM_001376450.1 NP_001363379.1 CUGBP Elav-like family member 1 isoform 12
NM_001376451.1 NP_001363380.1 CUGBP Elav-like family member 1 isoform 13
NM_001376452.1 NP_001363381.1 CUGBP Elav-like family member 1 isoform 14
NM_001376453.1 NP_001363382.1 CUGBP Elav-like family member 1 isoform 15
NM_001376454.1 NP_001363383.1 CUGBP Elav-like family member 1 isoform 16
NM_001376455.1 NP_001363384.1 CUGBP Elav-like family member 1 isoform 25
NM_001376456.1 NP_001363385.1 CUGBP Elav-like family member 1 isoform 17
NM_001376457.1 NP_001363386.1 CUGBP Elav-like family member 1 isoform 17
NM_001376458.1 NP_001363387.1 CUGBP Elav-like family member 1 isoform 18
NM_001376459.1 NP_001363388.1 CUGBP Elav-like family member 1 isoform 19
NM_001376460.1 NP_001363389.1 CUGBP Elav-like family member 1 isoform 19
NM_001376461.1 NP_001363390.1 CUGBP Elav-like family member 1 isoform 20
NM_001376462.1 NP_001363391.1 CUGBP Elav-like family member 1 isoform 20
NM_001376463.1 NP_001363392.1 CUGBP Elav-like family member 1 isoform 21
NM_006560.4 NP_006551.1 CUGBP Elav-like family member 1 isoform 1
NM_198700.3 NP_941989.1 CUGBP Elav-like family member 1 isoform 2

CELF1 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (19 - 84)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (110 - 175)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (403 - 472)

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  • 486 a.a.
Protein Preferred Names Protein Names

CUGBP Elav-like family member 1

50 kDa nuclear polyadenylated RNA-binding protein

Related Diseases

Diseases Alias
Myotonic Dystrophy 1

Myotonic Dystrophy

Dystrophia Myotonica

Steinert Disease

Myotonic Dystrophy Type 1

Myotonia Atrophica

DM1

Congenital Myotonic Dystrophy

Myotonia Dystrophica

Steinert Myotonic Dystrophy

Dystrophia Myotonica 1

Dm

Steinert'S Disease

Steinert Myotonic Dystrophy Syndrome

Myotonic Dystrophy Of Steinert

Dystrophia Myotonica Type 1

Myotonic Dystrophy Congenital

Dystrophy, Myotonic, Type 1

Dm - [Dystrophia Myotonica]

Myotonic Muscular Dystrophy
Myotonic Disease

Myotonic Disorders

Myotonic Syndrome

Symptomatic Myotonia
Myotonic Dystrophy 2

Myotonic Dystrophy Type 2

Proximal Myotonic Myopathy

Promm

Ricker Syndrome

DM2

Dystrophia Myotonica 2

Myotonic Myopathy, Proximal

Myotonic Disorders

Dystrophia Myotonica Type 2

Proximal Myotonic Dystrophy

Ricker Disease

Myotonic Dystrophy, Type 2

Dystrophy, Myotonic, Type 2
X-Linked Hereditary Ataxia
Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome

Fragile X Tremor/Ataxia Syndrome

Fxtas
Spinocerebellar Ataxia 8

Spinocerebellar Ataxia Type 8

SCA8

Ataxia, Spinocerebellar, Type 8
Huntington Disease-Like 2

HDL2

Huntington'S Disease-Like 2

Huntington Disease-Like, Type 2
Muscular Dystrophy

Muscular Dystrophies

Congenital Md

Congenital Muscular Dystrophy

Cmd

Mdc

Dystrophy, Muscular

Gower'S Muscular Dystrophy

Progressive Musclular Dystrophy

Pseudohypertrophic Atrophy

Pseudohypertrophic Muscle Paralysis

Pseudohypertrophic Muscular Atrophy

Pseudohypertrophic Muscular Dystrophy

Pseudohypertrophic Paralysis

Pseudomuscular Hypertrophy
Oculopharyngeal Muscular Dystrophy

OPMD

Muscular Dystrophy, Oculopharyngeal

Dystrophy, Oculopharyngeal Muscular

Oculopharyngeal Dystrophy

Progressive Muscular Dystrophy, Oculopharyngeal Type

Muscular Dystrophy Oculopharyngeal

Dystrophy, Muscular, Oculopharyngeal
Spinal And Bulbar Muscular Atrophy, X-Linked 1

Kennedy Disease

Sbma

Spinal And Bulbar Muscular Atrophy

Kennedy'S Disease

X-Linked Spinal And Bulbar Muscular Atrophy

SMAX1

Kd

Kennedy Spinal And Bulbar Muscular Atrophy

Spinobulbar Muscular Atrophy

Bulbospinal Muscular Atrophy, X-Linked

Bulbospinal Neuronopathy, X-Linked Recessive

Xbsn

Spinal And Bulbar Muscular Atrophy Of Kennedy

Bulbospinal Muscular Atrophy

X-Linked Bulbospinal Amyotrophy

Bulbo-Spinal Atrophy, X-Linked

Spinal Bulbar Muscular Atrophy

X-Linked Bulbo-Spinal Atrophy

X-Linked Spinal Bulbar Muscular Atrophy

X-Linked Bsma

X-Linked Bulbospinal Muscular Atrophy

Spinal And Bulbar Muscular Atrophy X-Linked 1

Bulbospinal Muscular Atrophy X-Linked

Bulbospinal Neuronopathy X-Linked Recessive

Kennedy Disease)

Kennedy Syndrome

Atrophy, Muscular, Spinal And Bulbar, Kennedy Type

Atrophy, Muscular, Spinobulbar

Bulbospinal Neuronopathy
Lens Disease

Lens Diseases
Neuromuscular Disease

Neuromuscular Diseases

Neuromuscular Disorders

Neuromuscular Disorder
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
Myopathy

Muscular Diseases

Myopathies
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02459 CELF1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CELF1 VGNC VGNC:60744
Rattus norvegicus CELF1 RGD RGD:1307721
Bos taurus CELF1 VGNC VGNC:27167
Mus musculus CELF1 MGD MGI:1342295
Canis familiaris CELF1 VGNC VGNC:39093
Macaca mulatta CELF1 VGNC VGNC:71098