SLC12A7 - solute carrier family 12 member 7 Gene

Homo sapiens

Also known as KCC4

Gene ID: 10723 | Gene type: protein coding

About SLC12A7

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:1,050,384-1,155,899 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 284 orthologues and 8 paralogues. Ubiquitous expression in testis (RPKM 14.3), kidney (RPKM 13.8) and 25 other tissues.

Summary

Enables protein kinase binding activity. Predicted to be involved in several processes, including cell volume homeostasis; inorganic ion homeostasis; and inorganic ion transmembrane transport. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

SLC12A7 Products(1)

mRNA	Protein	Name
NM_006598.3	NP_006589.2	solute carrier family 12 member 7

SLC12A7 Protein Structure

AA_permease

0
200
400
600
800
1000
1083 a.a.

Protein Preferred Names

Protein Names

solute carrier family 12 member 7

K-Cl cotransporter 4

Related Diseases

Diseases

Alias

Agenesis Of The Corpus Callosum With Peripheral Neuropathy

Andermann Syndrome	Charlevoix Disease
ACCPN	Polyneuropathy, Sensorimotor, With Or Without Agenesis Of The Corpus Callosum
Corpus Callosum, Agenesis Of, With Neuronopathy	Corpus Callosum Agenesis-Neuronopathy Syndrome
Agenesis Of Corpus Callosum With Neuronopathy	Agenesis Of Corpus Callosum With Peripheral Neuropathy
Agenesis Of Corpus Callosum With Polyneuropathy	Corpus Callosum Agenesis Neuronopathy
Hmsn/Acc	Hereditary Motor And Sensory Neuropathy With Agenesis Of The Corpus Callosum
Agenesis Of The Corpus Callosum, With Peripheral Neuropathy	Andermann'S Syndrome
Agenesis, Corpus Callosum, With Peripheral Neuropathy

Renal Tubular Acidosis

Acidosis Renal Tubular	Acidosis, Renal Tubular
Lightwood-Albright Syndrome	Lightwood Syndrome
Idiopathic Infantile Hypercalcemia - Mild Form	Kidney Tubular Acidosis
Renal Tubule Acidosis	Kidney Acidosis
Renal Acidosis	Renal Hyperchloremic Acidosis
Rta - [Renal Tubular Acidosis]

Hypomagnesemia 4, Renal

Renal Hypomagnesemia 4	HOMG4
Hypomagnesemia, Renal, Normocalciuric	Hypomagnesemia 4
Renal Hypomagnesemia Normocalciuric	Hypomagnesemia, Type 4, Renal

Seckel Syndrome 1

SCKL1	Nanocephalic Dwarfism
Microcephalic Primordial Dwarfism I	Seckel-Type Dwarfism
Bird-Headed Dwarfism	Sckl
Seckel Syndrome, Type 1	Seckel Syndrome

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive	Hydrocephalus, X-Linked
Hydrocephalus Adverse Event	Hydrocephaly Nos

Bartter Disease

Bartter Syndrome	Bartter'S Syndrome
Aldosteronism With Hyperplasia Of The Adrenal Cortex	Hypokalemic Alkalosis With Hypercalciuria
Potassium Wasting	Juxtaglomerular Hyperplasia With Secondary Aldosteronism
Renal Tubular Normotensive Hypokalemic Alkalosis With Hypercalciuria	Salt-Losing Tubular Disorder, Henle'S Loop Type
Salt-Wasting Tubulopathy, Henle'S Loop Type	Bartters Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13002	SLC12A7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC12A7	VGNC	VGNC:77390
Felis catus	SLC12A7	VGNC	VGNC:65193
Canis familiaris	SLC12A7	VGNC	VGNC:46224
Rattus norvegicus	SLC12A7	RGD	RGD:1359672
Bos taurus	SLC12A7	VGNC	VGNC:34670
Mus musculus	SLC12A7	MGD	MGI:1342283

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