STAG3 - stromal antigen 3 Gene

Also Known as SPGF61

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10734

About STAG3

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,177,724-100,219,334 (from NCBI)

This gene has 19 transcripts (splice variants), 205 orthologues, 2 paralogues and is associated with 3 phenotypes. Biased expression in testis (RPKM 44.6), brain (RPKM 6.1) and 2 other tissues.

Summary

The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014]

STAG3 Products (5)

mRNA Protein Name
NM_001282716.1 NP_001269645.1 cohesin subunit SA-3 isoform 1
NM_001282717.2 NP_001269646.1 cohesin subunit SA-3 isoform 2
NM_001282718.2 NP_001269647.1 cohesin subunit SA-3 isoform 3
NM_001375438.1 NP_001362367.1 cohesin subunit SA-3 isoform 2
NM_012447.4 NP_036579.2 cohesin subunit SA-3 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in establishment of meiotic sister chromatid cohesion IMP
IMP: Inferred from mutant phenotype
31682730 GOA
Cellular Component GO Annotation Evidence References Source
part of meiotic cohesin complex IDA
IDA: Inferred from direct assay
21242291 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAG3 Protein Structure

STAG

STAG: STAG domain (170 - 289)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1225 a.a.
Protein Preferred Names Protein Names

cohesin subunit SA-3

  • SCC3 homolog 3

Related Diseases

Diseases Alias
Premature Ovarian Failure 8

  • POF8

  • Ovarian Failure, Premature, Type 8
Spermatogenic Failure 61

  • SPGF61
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Infertility
46 Xx Gonadal Dysgenesis

  • Ovarian Dysgenesis

  • Gonadal Dysgenesis, 46,Xx

  • Dysgenesis, Ovarian
Amenorrhea

  • Absence Of Menstruation

  • Amenia
Cornelia De Lange Syndrome

  • De Lange Syndrome

  • Brachmann De Lange Syndrome

  • Brachmann-De Lange Syndrome

  • Cdls

  • Bdls

  • Typus Degenerativus Amstelodamensis
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Orofacial Cleft 8

  • OFC8

  • Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 8

  • Non-Syndromic Cleft Lip/Palate 8

  • Non-Syndromic Cleft Lip With Or Without Cleft Palate 8

  • Orofacial Cleft, Type 8
Bardet-Biedl Syndrome 12

  • BBS12

  • Bardet-Biedl Syndrome

  • Bbs

  • Bardet-Biedl Syndrome, Type 12
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Disorder Of Sexual Development

  • Disorder Of Sex Development

  • Disorders Of Sex Development

  • Sex Development Disorder

  • Sex Differentiation Disease

  • Dsd

  • Sex Differentiation Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13868 STAG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus STAG3 RGD RGD:621333
Canis familiaris STAG3 VGNC VGNC:54072
Macaca mulatta STAG3 VGNC VGNC:81766
Mus musculus STAG3 MGD MGI:1355311
Felis catus STAG3 VGNC VGNC:80685
Bos taurus STAG3 VGNC VGNC:97313
Others STAG3 NCBI