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Osr2 - odd-skipped related 2 Gene

Also Known as Osr2A; Osr2B; 5430409I15Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 107587

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; embryonic limb morphogenesis; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including embryonic skeletal system morphogenesis; kidney development; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human OSR2 (odd-skipped related transciption factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Osr2 Products (2)

mRNA	Protein	Name
NM_001368665.1	NP_001355594.1	protein odd-skipped-related 2 isoform 1
NM_054049.3	NP_473390.1	protein odd-skipped-related 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17547533	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17547533	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17547533	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in bone morphogenesis	IMP IMP: Inferred from mutant phenotype	17547533	MGI
involved in cell differentiation	IGI IGI: Inferred from genetic interaction	21262216	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15175245	MGI
involved in chondrocyte differentiation	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in embryo development ending in birth or egg hatching	IEP IEP: Inferred from expression pattern	11520675	MGI
involved in embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in embryonic forelimb morphogenesis	IEP IEP: Inferred from expression pattern	11520675	MGI
involved in embryonic forelimb morphogenesis	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in embryonic hindlimb morphogenesis	IEP IEP: Inferred from expression pattern	11520675	MGI
involved in embryonic hindlimb morphogenesis	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in embryonic skeletal joint development	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in embryonic skeletal joint morphogenesis	IMP IMP: Inferred from mutant phenotype	21262216	MGI
involved in embryonic skeletal limb joint morphogenesis	IGI IGI: Inferred from genetic interaction	21262216	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	15175245	MGI
involved in eyelid development in camera-type eye	IMP IMP: Inferred from mutant phenotype	19389375	MGI
involved in head development	IMP IMP: Inferred from mutant phenotype	21262216	MGI
involved in mesonephros development	IEP IEP: Inferred from expression pattern	11520675	MGI
involved in metanephros development	IEP IEP: Inferred from expression pattern	11520675	MGI
involved in middle ear morphogenesis	IMP IMP: Inferred from mutant phenotype	19389375	MGI
involved in negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in odontogenesis	IMP IMP: Inferred from mutant phenotype	19389375	MGI
involved in osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	17547533	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17547533	MGI
involved in positive regulation of bone mineralization	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	19389375	MGI
involved in positive regulation of gastrulation	IMP IMP: Inferred from mutant phenotype	21281489	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17547533	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	15175245	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17547533	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in pronephros development	IMP IMP: Inferred from mutant phenotype	21281489	MGI
involved in roof of mouth development	IMP IMP: Inferred from mutant phenotype	19389375	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	15175245	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	17547533	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein odd-skipped-related 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09853	OSR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Osr2	NCBI	NCBI:116039