OSR2 - odd-skipped related transciption factor 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 116039

About OSR2

Cytogenetic location: 8q22.2 Genomic coordinates (GRCh38): 8:98,944,442-98,952,100 (from NCBI)

This gene has 10 transcripts (splice variants), 197 orthologues and 1 paralogue. Biased expression in endometrium (RPKM 68.5), ovary (RPKM 33.5) and 8 other tissues.

Summary

OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004 [PubMed 15175245]).[supplied by OMIM, Mar 2008]

OSR2 Products (4)

mRNA Protein Name
NM_001142462.3 NP_001135934.1 protein odd-skipped-related 2 isoform a
NM_001286841.2 NP_001273770.1 protein odd-skipped-related 2 isoform c
NM_001394683.1 NP_001381612.1 protein odd-skipped-related 2 isoform d
NM_053001.4 NP_443727.2 protein odd-skipped-related 2 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSR2 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (186 - 210)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (214 - 237)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (256 - 278)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (284 - 306)

  • 0
  • 100
  • 200
  • 312 a.a.
Protein Preferred Names Protein Names

protein odd-skipped-related 2

  • odd-skipped related 2

OSR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OSR2 Q8N2R0 PSMA3 Homo sapiens P25788
Y2H Array
25416956
Intra
OSR2 Q8N2R0 PSMA3 Homo sapiens P25788
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cleft Soft Palate

  • Cleft Velum

  • Cleft Velum Palatinum

  • Soft Cleft Palate

  • Soft Palate Perforation
Blepharophimosis, Ptosis, And Epicanthus Inversus

  • Blepharophimosis, Ptosis, And Epicanthus Inversus Syndrome

  • BPES

  • Blepharophimosis Syndrome

  • Blepharophimosis, Epicanthus Inversus, And Ptosis, Type 1

  • Blepharophimosis, Ptosis, Epicanthus Inversus Syndrome

  • Bpes With Duane Retraction Syndrome

  • Blepharophimosis, Ptosis, And Epicanthus Inversus Syndrome Type 2

  • Blepharophimosis, Ptosis, And Epicanthus Inversus Syndrome Type 1

  • Blepharophimosis, Epicanthus Inversus, And Ptosis, Type 2

  • Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome

  • Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Type 2

  • Bpes Type 2

  • Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Without Premature Ovarian Failure

  • Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Plus

  • 3q23 Microdeletion Syndrome

  • Bpes Plus

  • Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Type 1

  • Bpes Type 1

  • Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome With Premature Ovarian Failure

  • Blepharophimosis, Ptosis, Epicanthus Inversus

  • Autosomal Dominant Bpes Type I

  • Autosomal Recessive Bpes Type I

  • Bpes Type I

  • Bpes Type Ii

  • Bpes Without Ovarian Failure

  • Bpes With Ovarian Failure

  • Blepharophimosis Syndrome Type 1

  • Blepharophimosis Syndrome Type 2
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Peptic Ulcer Perforation

  • Perforated Peptic Ulcer

  • Acute Peptic Ulcer With Perforation

  • Peptic Ulcer With Perforation
Cleft Palate With Or Without Ankyloglossia, X-Linked

  • Cleft Palate With Ankyloglossia

  • CPX

  • X-Linked Cleft Palate And Ankyloglossia

  • X-Linked Cleft Palate With Or Without Ankyloglossia

  • X-Linked Cleft Palate

  • X-Linked Cleft Palate With Ankyloglossia

  • Cleft Palate, With/Without Ankyloglossia, X-Linked
Orofacial Cleft

  • Cleft, Orofacial
Tooth Agenesis

  • Oligodontia

  • Hypodontia

  • Selective Tooth Agenesis

  • Tooth Agenesis, Selective

  • Familial Tooth Agenesis

  • Anodontia

  • Congenital Absence Of One Tooth
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09853 OSR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta OSR2 VGNC VGNC:84097
Rattus norvegicus OSR2 RGD RGD:1305812
Canis familiaris OSR2 VGNC VGNC:44169
Bos taurus OSR2 VGNC VGNC:32477
Felis catus OSR2 VGNC VGNC:63990
Mus musculus OSR2 MGD MGI:1930813
Others OSR2 NCBI